Search Results - "Whatmore, Andrew J."

A pilot study to evaluate gene expression profiles in peripheral blood mononuclear cells (PBMCs) from children with GH deficiency and Turner syndrome in response to GH treatment by Whatmore, Andrew J., Patel, Leena, Clayton, Peter E.

“…Summary Response to GH treatment is variable and dependent on diagnosis and dose. We used a pharmacogenomic approach to assess whether this variability is…”
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Reduced Pericellular Sensitivity to IGF-I in Fibroblasts From Girls With Turner Syndrome: A Mechanism to Impair Clinical Responses to GH by Westwood, Melissa, Tajbakhsh, Shahin H, Siddals, Kirk W, Whatmore, Andrew J, Clayton, Peter E

“…Girls with Turner syndrome (TS) are treated with supraphysiological doses of growth hormone (GH) to improve final height; however in some girls, the growth…”
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The effect of different patterns of growth hormone administration on the IGF axis and somatic and skeletal growth of the dwarf rat by Westwood, Melissa, Maqsood, Arfa R, Solomon, Mattea, Whatmore, Andrew J, Davis, Julian R E, Baxter, Robert C, Gevers, Evelien F, Robinson, Iain C A F, Clayton, Peter E

“…Normal childhood growth is determined by ultradian and infradian variations in GH secretion, yet GH treatment of children with short stature is restricted to…”
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The relationship between nocturnal urinary leptin and gonadotrophins as children progress towards puberty by Maqsood, Arfa R, Trueman, Julie A, Whatmore, Andrew J, Westwood, Melissa, Price, David A, Hall, Catherine M, Clayton, Peter E

“…Leptin is necessary for normal human pubertal development but its exact role in the period leading up to the onset of puberty has not been defined. This study…”
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Variability in anterior pituitary size within members of a family with GH deficiency due to a new splice mutation in the GHRH receptor gene by Alba, Maria, Hall, Catherine M., Whatmore, Andrew J., Clayton, Peter E., Price, David A., Salvatori, Roberto

“…Summary objective  Mutations in the GHRH receptor (GHRHR) gene (GHRHR) cause autosomal recessive isolated GH deficiency (IGHD), and are usually associated with…”
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Serum leptin through childhood and adolescence by Clayton, Peter E., Gill, Matthew S., Hall, Catherine M., Tillmann, Vallo, Whatmore, Andrew J., Price, David A.

“…OBJECTIVE Leptin is the protein product of the recently cloned ob gene, that has been implicated in the control of body weight and thermogenesis, but also…”
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Phenotypic variation in constitutional delay of growth and puberty: relationship to specific leptin and leptin receptor gene polymorphisms by Banerjee, Indraneel, Trueman, Julie A, Hall, Catherine M, Price, David A, Patel, Leena, Whatmore, Andrew J, Hirschhorn, Joel N, Read, Andrew P, Palmert, Mark R, Clayton, Peter E

“…Objectives: Constitutional delay of growth and puberty (CDGP) is a variant of normal pubertal timing and progress, often with dominant inheritance. It is…”
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The contributions of plasma IGF-I, IGFBP-3 and leptin to growth in extremely premature infants during the first two years by PATEL, Leena, CAVAZZONI, Elena, WHATMORE, Andrew J, CARNEY, Sally, WALES, Jeremy K, CLAYTON, Peter E, GIBSON, Alan T

“…We determined the contributions of IGF-I, IGFBP-3 and leptin to growth in extremely premature infants over the first two years. Weight (Wt), crown-to heel…”
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A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency by CARAKUSHANSKY, Mauri, WHATMORE, Andrew J, CLAYTON, Peter E, SHALET, Stephen M, GLEESON, Helena K, PRICE, David A, LEVINE, Michael A, SALVATORI, Roberto

“…Mutations in the GH-releasing hormone (GHRH) receptor (GHRHR) gene (GHRHR) cause autosomal recessive familial isolated GH deficiency (IGHD). We searched for…”
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Activation of the Signal Transducers and Activators of Transcription Signaling Pathway by Growth Hormone (GH) in Skin Fibroblasts from Normal and GH Binding Protein-Positive Laron Syndrome Children by Freeth, James S, Silva, Corinne M, Whatmore, Andrew J, Clayton, Peter E

“…We have previously described two families (H and M) with GH binding protein-positive Laron Syndrome (LS), proposed to have one or more post GHR signaling…”
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GH and Epidermal Growth Factor Signaling in Normal and Laron Syndrome Fibroblasts by Silva, Corinne M, Kloth, Michael T, Whatmore, Andrew J, Freeth, James S, Anderson, Neil, Laughlin, Kristen K, Huynh, Trang, Woodall, Alyson J, Clayton, Peter E

“…We have investigated and compared GH and epidermal growth factor (EGF) signaling in primary human skin fibroblasts from normal subjects and subjects with…”
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Growth Hormone Stimulation of the Mitogen-Activated Protein Kinase Pathway Is Cell Type Specific by Love, Dexter W., Whatmore, Andrew J., Clayton, Peter E., Silva, Corinne M.

“…Abstract The GH receptor is a member of the cytokine receptor superfamily. Studies in the 3T3-F442A mouse preadipocyte have shown that GH activates the Janus…”
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Leptin measurement in urine in children and its relationship to other growth peptides in serum and urine by Zaman, Nasra, Hall, Catherine M., Gill, Matthew S., Jones, Julie, Tillmann, Vallo, Westwood, Melissa, Whatmore, Andrew J., Clayton, Peter E.

“…Summary objective Leptin has been implicated in the interaction between nutrition, energy balance and sexual maturation in humans. A non‐invasive method of…”
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Human Skin Fibroblasts as a Model of Growth Hormone (GH) Action in GH Receptor-Positive Laron’s Syndrome by Freeth, James S, Ayling, Ruth M, Whatmore, Andrew J, Towner, Paul, Price, D. Anthony, Norman, Michael R, Clayton, Peter E

“…Congenital GH insensitivity (Laron’s syndrome, LS) is often associated with a dysfunctional GH receptor (GHR) causing complete insensitivity to GH and absent…”
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GH and epidermal growth factor signaling in normal and Laron syndrome fibroblasts by Silva, Corinne M, Kloth, Michael T, Whatmore, Andrew J, Freeth, James S, Anderson, Neil, Laughlin, Kristen K, Huynh, Trang, Woodall, Alyson J, Clayton, Peter E

“…We have investigated and compared GH and epidermal growth factor (EGF) signaling in primary human skin fibroblasts from normal subjects and subjects with…”
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Growth Hormone Stimulation of the Mitogen-Activated Protein Kinase Pathway Is Cell Type Specific1 by Love, Dexter W, Whatmore, Andrew J, Clayton, Peter E, Silva, Corinne M

“…The GH receptor is a member of the cytokine receptor superfamily. Studies in the 3T3-F442A mouse preadipocyte have shown that GH activates the Janus kinase…”
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Infradian rhythms in urinary growth hormone excretion by THALANGE, N. K. S, GILL, M. S, GILL, L, WHATMORE, A. J, ADDISON, G. M, PRICE, D. A, CLAYTON, P. E

“…All studies of urinary GH excretion in normal and disordered growth have revealed marked day to day (infradian) variation. We used serial overnight urinary GH…”
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Differential responsiveness of receptor tyrosylkinases to inhibitors: analysis of insulin and epidermal growth factor receptor sensitivity in cultured rat hepatocytes by Whatmore, A J, Dickson, A J

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Glycolipids isolated from cultured rat hepatocytes: analysis of their role in insulin signal transduction by Whatmore, A J, Bate, A J, Dickson, A J

“…The precise mechanism by which insulin elicits its effects remains to be fully determined. A glycophospholipid, isolated from H35 cells, has been proposed as a…”
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Dexamethasone inhibits sugar incorporation into glycolipids in cultured rat hepatocytes by Whatmore, A J, Jarett, L, Dickson, A J

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