Search Results - "Whatmore, AJ"

A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency by CARAKUSHANSKY, Mauri, WHATMORE, Andrew J, CLAYTON, Peter E, SHALET, Stephen M, GLEESON, Helena K, PRICE, David A, LEVINE, Michael A, SALVATORI, Roberto

“…Mutations in the GH-releasing hormone (GHRH) receptor (GHRHR) gene (GHRHR) cause autosomal recessive familial isolated GH deficiency (IGHD). We searched for…”
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Ghrelin concentrations in healthy children and adolescents by Whatmore, A. J., Hall, C. M., Jones, J., Westwood, M., Clayton, P. E.

“…Summary objective  In addition to its regulation by GH releasing hormone (GHRH) and somatostatin, release of GH from the pituitary is modulated by a third…”
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Patient selection for IGF-I therapy by Clayton, P E, Ayoola, O, Whatmore, A J

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Variability in anterior pituitary size within members of a family with GH deficiency due to a new splice mutation in the GHRH receptor gene by Alba, Maria, Hall, Catherine M., Whatmore, Andrew J., Clayton, Peter E., Price, David A., Salvatori, Roberto

“…Summary objective  Mutations in the GHRH receptor (GHRHR) gene (GHRHR) cause autosomal recessive isolated GH deficiency (IGHD), and are usually associated with…”
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Serum leptin through childhood and adolescence by Clayton, Peter E., Gill, Matthew S., Hall, Catherine M., Tillmann, Vallo, Whatmore, Andrew J., Price, David A.

“…OBJECTIVE Leptin is the protein product of the recently cloned ob gene, that has been implicated in the control of body weight and thermogenesis, but also…”
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Biochemical tests in the diagnosis of childhood growth hormone deficiency by TILLMANN, V, BUCKLER, J. M. H, KIBIRIGE, M. S, PRICE, D. A, SHALET, S. M, WALES, J. K. H, ADDISON, M. G, GILL, M. S, WHATMORE, A. J, CLAYTON, P. E

“…GH stimulation tests are widely used in the diagnosis of GH deficiency (GHD), although they are associated with a high false positive rate. We have examined,…”
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Monitoring serum insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), IGF-I/IGFBP-3 molar ratio and leptin during growth hormone treatment for disordered growth by TILLMANN, V, PATEL, L, GILL, M. S, WHATMORE, A. J, PRICE, D. A, KIBIRIGE, M. S, WALES, J. K, CLAYTON, P. E

“…OBJECTIVE Serum IGF‐I levels are monitored during GH replacement treatment in adults with GH deficiency (GHD) to guide GH dose adjustment and to minimize…”
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The effect of pegvisomant-induced serum IGF-I normalization on serum leptin levels in patients with acromegaly by Parkinson, C., Whatmore, A. J., Yates, A. P., Drake, W. M., Brabant, G., Clayton, P. E., Trainer, P. J.

“…Summary background In humans, serum leptin correlates positively with fat mass. GH is lipolytic and patients with active acromegaly have lowered serum leptin…”
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GH and epidermal growth factor signaling in normal and Laron syndrome fibroblasts by Silva, Corinne M, Kloth, Michael T, Whatmore, Andrew J, Freeth, James S, Anderson, Neil, Laughlin, Kristen K, Huynh, Trang, Woodall, Alyson J, Clayton, Peter E

“…We have investigated and compared GH and epidermal growth factor (EGF) signaling in primary human skin fibroblasts from normal subjects and subjects with…”
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Growth hormone stimulation of the mitogen-activated protein kinase pathway is cell type specific by Love, D W, Whatmore, A J, Clayton, P E, Silva, C M

“…The GH receptor is a member of the cytokine receptor superfamily. Studies in the 3T3-F442A mouse preadipocyte have shown that GH activates the Janus kinase…”
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Activation of the signal transducers and activators of transcription signaling pathway by growth hormone (GH) in skin fibroblasts from normal and GH binding protein-positive Laron Syndrome children by Freeth, J S, Silva, C M, Whatmore, A J, Clayton, P E

“…We have previously described two families (H and M) with GH binding protein-positive Laron Syndrome (LS), proposed to have one or more post GHR signaling…”
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IGF-I and IGF-binding protein-3 measurements on filter paper blood spots in children and adolescents on GH treatment: use in monitoring and as markers of growth performance by Das, U, Whatmore, AJ, Khosravi, J, Wales, JK, Butler, G, Kibirige, MS, Diamandi, A, Jones, J, Patel, L, Hall, CM, Price, DA, Clayton, PE

“…BACKGROUND/AIM: In childhood an appropriate response to GH treatment is achieved by titration of growth response against dose administered, with careful…”
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Leptin measurement in urine in children and its relationship to other growth peptides in serum and urine by Zaman, Nasra, Hall, Catherine M., Gill, Matthew S., Jones, Julie, Tillmann, Vallo, Westwood, Melissa, Whatmore, Andrew J., Clayton, Peter E.

“…Summary objective Leptin has been implicated in the interaction between nutrition, energy balance and sexual maturation in humans. A non‐invasive method of…”
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Urinary IGF and IGF binding protein-3 in children with disordered growth by Gill, M. S., Whatmore, A. J., Tillman, V., White, A., Addison, G. M., Price, D. A., Clayton, P. E.

“…OBJECTIVE Both IGF‐l and IGFBP‐3 reflect spontaneous GH secretion in healthy individuals. We have evaluated the clinical usefulness of urinary IGF‐I and…”
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Signal transduction defects in growth hormone insensitivity by Clayton, PE, Freeth, JS, Whatmore, AJ, Ayling, RM, Norman, MR, Silva, CM

“…Clayton PE, Freeth JS, Whatmore AJ, Ayling RM, Norman MR, Silva CM. Signal transduction defects in growth hormone insensitivity. Acta Pædiatr 1999; Suppl 428:…”
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Human skin fibroblasts as a model of growth hormone (GH) action in GH receptor-positive Laron's syndrome by FREETH, J. S, AYLING, R. M, WHATMORE, A. J, TOWNER, P, PRICE, D. A, NORMAN, M. R, CLAYTON, P. E

“…Congenital GH insensitivity (Laron's syndrome, LS) is often associated with a dysfunctional GH receptor (GHR) causing complete insensitivity to GH and absent…”
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Insulin-like growth factor binding protein-3 generation : An index of growth hormone insensitivity by THALANGE, N. K. S, PRICE, D. A, GILL, M. S, WHATMORE, A. J, ADDISON, G. M, CLAYTON, P. E

“…GH insensitivity may be an inherited condition or may arise as a consequence of disease of malnutrition. Laron syndrome is the most severe form of GH…”
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Serum insulin-like growth factor-I, IGF binding protein-3 and IGFBP-3 protease activity after cranial irradiation by Tillmann, V, Shalet, S M, Price, D A, Wales, J K, Pennells, L, Soden, J, Gill, M S, Whatmore, A J, Clayton, P E

“…The relationship between peak growth hormone (GH), insulin-like growth factor I (IGF-I), IGF-I binding protein 3 (IGFBP-3) and IGFBP-3 protease activity was…”
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Infradian rhythms in urinary growth hormone excretion by THALANGE, N. K. S, GILL, M. S, GILL, L, WHATMORE, A. J, ADDISON, G. M, PRICE, D. A, CLAYTON, P. E

“…All studies of urinary GH excretion in normal and disordered growth have revealed marked day to day (infradian) variation. We used serial overnight urinary GH…”
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Glycolipids isolated from cultured rat hepatocytes: analysis of their role in insulin signal transduction by Whatmore, A J, Bate, A J, Dickson, A J

“…The precise mechanism by which insulin elicits its effects remains to be fully determined. A glycophospholipid, isolated from H35 cells, has been proposed as a…”
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