Search Results - "Wharton, S. B."

Age‐associated changes in the blood‐brain barrier: comparative studies in human and mouse by Goodall, E. F., Wang, C., Simpson, J. E., Baker, D. J., Drew, D. R., Heath, P. R., Saffrey, M. J., Romero, I. A., Wharton, S. B.

“…Aims While vascular pathology is a common feature of a range of neurodegenerative diseases, we hypothesized that vascular changes occur in association with…”
Get full text

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain by Simpson, J.E, Ince, P.G, Lace, G, Forster, G, Shaw, P.J, Matthews, F, Savva, G, Brayne, C, Wharton, S.B

“…Abstract Astrocyte pathology occurs in association with Alzheimer's disease (AD) and in brain ageing, but is poorly characterised. We sought to define the…”
Get full text

Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study by Lace, G., Savva, G. M., Forster, G., de Silva, R., Brayne, C., Matthews, F. E., Barclay, J. J., Dakin, L., Ince, P. G., Wharton, S. B.

“…Deposits of abnormally phosphorylated tau protein are found in numerous neurodegenerative disorders; the ‘tauopathies’, which include Alzheimer's and Pick's…”
Get full text

Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds by Janaway, B. M., Simpson, J. E., Hoggard, N., Highley, J. R., Forster, G., Drew, D., Gebril, O. H., Matthews, F. E., Brayne, C., Wharton, S. B., Ince, P. G.

“…Introduction Magnetic resonance imaging (MRI) cerebral microbleeds (CMB) arise from ferromagnetic haemosiderin iron assumed to derive from extravasation of…”
Get full text

White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses by Simpson, J. E., Fernando, M. S., Clark, L., Ince, P. G., Matthews, F., Forster, G., O'Brien, J. T., Barber, R., Kalaria, R. N., Brayne, C., Shaw, P. J., Lewis, C. E., Wharton, S. B.

“…Hyperintense lesions are frequently identified in T2‐weighted magnetic resonance images (MRI) in the ageing brain. The pathological correlate and pathogenesis…”
Get full text

Sensory ganglionopathy due to gluten sensitivity by HADJIVASSILIOU, M, RAO, D. G, WHARTON, S. B, SANDERS, D. S, GRÜNEWALD, R. A, DAVIES-JONES, A. G. B

“…Gluten sensitivity can engender neurologic dysfunction, one of the two commonest presentations being peripheral neuropathy. The commonest type of neuropathy…”
Get full text

Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches by Wharton, S B, Wang, D, Parikh, C, Matthews, F E, Brayne, C, Ince, P G

“…Aβ-amyloid deposition is a key feature of Alzheimer's disease, but Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, based on…”
Get full text

Corticospinal tract degeneration in the progressive muscular atrophy variant of ALS by INCE, P. G, EVANS, J, KNOPP, M, FORSTER, G, HAMDALLA, H. H. M, WHARTON, S. B, SHAW, P. J

“…Examining the unresolved relationship between the lower motor neuron disorder progressive muscular atrophy (PMA) and ALS is important in clinical practice…”
Get full text

Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain by Simpson, J. E., Ince, P. G., Haynes, L. J., Theaker, R., Gelsthorpe, C., Baxter, L., Forster, G., Lace, G. L., Shaw, P. J., Matthews, F. E., Savva, G. M., Brayne, C., Wharton, S. B.

“…J. E. Simpson, P. G. Ince, L. J. Haynes, R. Theaker, C. Gelsthorpe, L. Baxter, G. Forster, G. L. Lace, P. J. Shaw, F. E. Matthews, G. M. Savva, C. Brayne and…”
Get full text

Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort by Lace, G, Ince, P G, Brayne, C, Savva, G M, Matthews, F E, de Silva, R, Simpson, J E, Wharton, S B

“…Glial tau pathology is seen in certain tauopathies and in ageing. We determined its frequency in ageing mesial temporal lobe and its relationship to other tau…”
Get more information

Neuropathy associated with gluten sensitivity by Hadjivassiliou, M, Grünewald, R A, Kandler, R H, Chattopadhyay, A K, Jarratt, J A, Sanders, D S, Sharrack, B, Wharton, S B, Davies-Jones, G A B

“…Objectives: To prospectively study the clinical, neurophysiological and neuropathological characteristics of axonal neuropathies associated with positive…”
Get full text

Microglial activation in white matter lesions and nonlesional white matter of ageing brains by Simpson, J. E., Ince, P. G., Higham, C. E., Gelsthorpe, C. H., Fernando, M. S., Matthews, F., Forster, G., O'Brien, J. T., Barber, R., Kalaria, R. N., Brayne, C., Shaw, P. J., Stoeber, K., Williams, G. H., Lewis, C. E., Wharton, S. B.

“…White matter lesions (WML), a common feature in brain ageing, are classified as periventricular (PVL) or deep subcortical (DSCL), depending on their anatomical…”
Get full text

Review: Astrocytes in Alzheimer's disease and other age‐associated dementias: a supporting player with a central role by Garwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., Wharton, S. B.

“…Astrocytes have essential roles in the central nervous system and are also implicated in the pathogenesis of neurodegenerative disease. Forming non‐overlapping…”
Get full text

Myopathy associated with gluten sensitivity by Hadjivassiliou, Marios, Chattopadhyay, Arup K., Grünewald, Richard A., Jarratt, John A., Kandler, Rosalind H., Rao, D. G., Sanders, D. S., Wharton, S. B., Davies-Jones, G. A. B.

“…Ataxia and peripheral neuropathy are the most common neurological manifestations of gluten sensitivity. Myopathy is a less common and poorly characterized…”
Get full text

Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia by Wharton, S B, O'Callaghan, J P, Savva, G M, Nicoll, J A R, Matthews, F, Simpson, J E, Forster, G, Shaw, P J, Brayne, C, Ince, P G

“…The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely…”
Get more information

DNA replication licensing and cell cycle kinetics of oligodendroglial tumours by WHARTON, S. B, HIBBERD, S, EWARD, K. L, CRIMMINS, D, JELLINEK, D. A, LEVY, D, STOEBER, K, WILLIAMS, G. H

“…The convergence point of growth-signalling pathways that control cell proliferation is the initiation of genome replication, the core of which is the assembly…”
Get full text

Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggests neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease by Vazquez‐Villaseñor, I., Garwood, C. J., Heath, P. R., Simpson, J. E., Ince, P. G., Wharton, S. B.

“…Aims Cellular senescence plays a role in organismal ageing and has been linked to persistent DNA damage in age‐related diseases. Brain senescence has been…”
Get full text

Microinfarcts in an older population‐representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease by Ince, P. G., Minett, T., Forster, G., Brayne, C., Wharton, S. B.

“…Introduction Microinfarcts, small ischaemic foci common in ageing brain, are associated with dementia and gait dysfunction. We determined their relationship…”
Get full text

Replicative Mcm2 protein as a novel proliferation marker in oligodendrogliomas and its relationship to Ki67 labelling index, histological grade and prognosis by Wharton, S. B., Chan, K. K., Anderson, J. R., Stoeber, K., Williams, G. H.

“…The grading and prognostic assessment of oligodendrogliomas is severely constrained and there remains a need for improved diagnosis. Recently, we have…”
Get full text

Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease by Ameen‐Ali, K. E., Wharton, S. B., Simpson, J. E., Heath, P. R., Sharp, P., Berwick, J.

“…Our understanding of the underlying biology of Alzheimer's disease (AD) has been steadily progressing; however, this is yet to translate into a successful…”
Get full text