Search Results - "Whalley, E T"

Serum IL-17F does not predict poor response to IM IFNβ-1a in relapsing-remitting MS by BUSHNELL, S. E, ZHAO, Z, STEINMAN, L, MEDORI, R, STEBBINS, C. C, CADAVID, D, BUKO, A. M, WHALLEY, E. T, DAVIS, J. A, VERSAGE, E. M, RICHERT, J. R, AXTELL, R. C

“…There is a significant unmet need for serum biomarkers in relapsing-remitting multiple sclerosis (RRMS) that are predictive of therapeutic response to…”
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Serum IL-17F does not predict poor response to IM IFN beta -1a in relapsing-remitting MS by Bushnell, SE, Zhao, Z, Stebbins, C C, Cadavid, D, Buko, A M, Whalley, E T, Davis, JA, Versage, E M, Richert, J R, Axtell, R C, Steinman, L, Medori, R

“…Objective: There is a significant unmet need for serum biomarkers in relapsing-remitting multiple sclerosis (RRMS) that are predictive of therapeutic response…”
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CP-0597, a selective bradykinin B2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion by Relton, J K, Beckey, V E, Hanson, W L, Whalley, E T

“…Recent studies demonstrated a significant neuroprotective action of the selective peptide-based bradykinin B2 receptor antagonist CP-0597 after permanent…”
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5‐HT1‐like receptors mediate 5‐hydroxytryptamine‐induced contraction of human isolated basilar artery by Parsons, Andrew A., Whalley, Eric T., Feniuk, Wasyl, Connor, Helen E., Humphrey, Patrick P.A.

“…1 The 5‐hydroxytryptamine (5‐HT) receptor mediating contraction of endothelium denuded human basilar artery has been characterized in vitro. 2 5‐HT and a…”
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Potent, long-acting bradykinin antagonists for a wide range of applications by Stewart, J M, Gera, L, Chan, D C, Whalley, E T, Hanson, W L, Zuzack, J S

“…Actions of bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; BK) are mediated by constitutively expressed B2 receptors (which require the full BK peptide chain)…”
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Bradykinin receptor antagonists type 2 attenuate the inflammatory changes in peptidoglycan-induced acute arthritis in the Lewis rat by Uknis, A B, DeLa Cadena, R A, Janardham, R, Sartor, R B, Whalley, E T, Colman, R W

“…We studied the ability of bradykinin (BK) receptor antagonists type 1 and 2 (B1-RA, B2-RA) to prevent acute inflammation. A peptidoglycan-polysaccharide…”
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Rationale for the use of 5-HT1-like agonists in the treatment of migraine by FENIUK, W, HUMPHREY, P. P. A, PERREN, M. J, CONNOR, H. E, WHALLEY, E. T

“…Migraine headache is thought to be associated with a dilatation of cranial blood vessels, particularly those in the dura mater, and an accompanying localized…”
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The effect of kinin agonists and antagonists on the pain response of the human blister base by WHALLEY, E. T, CLEGG, S, STEWART, J. M, VAVREK, R. J

“…1. The effect of bradykinin (BK) and some analogues of BK on the human blister base was studied. 2. BK produced reproducible dose-related increases in pain…”
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New synthetic antagonists of bradykinin by Schachter, M., Uchida, Y., Longridge, D.J., Labedz, T., Whalley, E.T., Vavrek, R.J., Stewart, J.M.

“…1 A new synthetic bradykinin analogue was found to be an antagonist of bradykinin‐induced vascular permeability in rabbit skin. It was effective in equimolar…”
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Pharmacological profiles of the human and rabbit B1 receptors by Gobeil, F, Neugebauer, W, Nguyen-Le, X K, Nea Allogho, S, Pheng, L H, Blouin, D, Whalley, E T, Regoli, D

“…Twenty-two peptides related to kinins were used (i) to examine some chemical features required for the human and rabbit B1 receptor activation or blockade and…”
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Cerebrovascular reactivity to angiotensin and angiotensin-converting enzyme activity in cerebrospinal fluid by Whalley, E T, Wahl, M

“…The purpose of the present study was to test the vasomotor effect of angiotensin I (A I) and angiotensin II (A II) in feline cerebral arteries and to examine…”
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Evidence of a bradykinin B1 receptor in human ileum: pharmacological comparison to the rabbit aorta B1 receptor by Zuzack, J S, Burkard, M R, Cuadrado, D K, Greer, R A, Selig, W M, Whalley, E T

“…Bradykinin B1 receptors have been identified in a limited number of human tissues and may have implications in pathological states of chronic inflammation. In…”
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Analysis of the mechanism of action of bradykinin on human basilar artery in vitro by WHALLEY, E. T, AMURE, Y. O, LYE, R. H

“…Bradykinin (BK) initially produced concentration-related relaxations of human basilar artery in vitro. Concentration-effect curves constructed at 2 h intervals…”
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Metabolism of bradykinin and angiotensin I by human basilar artery and rabbit aorta by WHALLEY, E. T

“…The role of angiotensin converting enzyme in the metabolism of bradykinin and angiotensin I by in vitro human basilar artery and rabbit aorta was studied. On…”
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Attenuation of arterial blood pressure fall in endotoxin shock in the rat using the competitive bradykinin antagonist Lys‐Lys‐[Hyp2, Thi5,8, DPhe7]‐Bk (B4148) by Weipert, J., Hoffmann, H., Siebeck, M., Whalley, E.T.

“…The selective competitive bradykinin (Bk) antagonist, B4148 (Lys‐Lys‐[Hyp2, Thi5,8, DPhe7]‐Bk) infused at 100 μg kg−1 min−1 into rats produced a significant…”
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Kinin receptors and angiotensin converting enzyme in rabbits basilar arteries by WHALLEY, E. T, FRITZ, H, GEIGER, R

“…Bradykinin (BK) initially produced concentration related relaxations of the rabbit basilar artery in vitro under resting tension and when contracted with…”
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Oral activity of peptide bradykinin antagonists following intragastric administration in the rat by Whalley, E T, Hanson, W L, Stewart, J M, Gera, L

“…This study has investigated the oral activity, following intragastric administration, of three potent and long-acting peptide-based bradykinin antagonists,…”
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Evidence for the presence of 5-HT1-like receptors in rabbit isolated basilar arteries by Parsons, A A, Whalley, E T

“…The 5-hydroxytryptamine (5-HT) receptor mediating contraction of rabbit isolated endothelium denuded basilar artery has been investigated. 5-HT and a variety…”
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Receptors mediating the increase in vascular permeability to kinins: comparative studies in rat, guinea-pig and rabbit by WHALLEY, E. T

“…The effect of bradykinin (BK) and a variety of kinin analogues and modified kinin fragments were assessed in several models representing the vascular…”
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Analysis of the receptors mediating vascular actions of bradykinin by WHALLEY, E. T, NWATOR, I. A, STEWART, J. M, VAVREK, R. J

“…A range of bradykinin (BK) analogues was assessed for their ability to antagonise the action of BK on rabbit jugular vein, a B2-receptor containing tissue, and…”
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