Search Results - "Whaley, Ryan"

An Evidence‐Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine by Whirl‐Carrillo, Michelle, Huddart, Rachel, Gong, Li, Sangkuhl, Katrin, Thorn, Caroline F., Whaley, Ryan, Klein, Teri E.

“…Clinical annotations are one of the most popular resources available on the Pharmacogenomics Knowledgebase (PharmGKB). Each clinical annotation summarizes the…”
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Pharmacogenomics Clinical Annotation Tool (PharmCAT) by Sangkuhl, Katrin, Whirl‐Carrillo, Michelle, Whaley, Ryan M., Woon, Mark, Lavertu, Adam, Altman, Russ B., Carter, Lester, Verma, Anurag, Ritchie, Marylyn D., Klein, Teri E.

“…Pharmacogenomics (PGx) decision support and return of results is an active area of precision medicine. One challenge of implementing PGx is extracting genomic…”
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How to Run the Pharmacogenomics Clinical Annotation Tool (PharmCAT) by Li, Binglan, Sangkuhl, Katrin, Keat, Karl, Whaley, Ryan M., Woon, Mark, Verma, Shefali, Dudek, Scott, Tuteja, Sony, Verma, Anurag, Whirl‐Carrillo, Michelle, Ritchie, Marylyn D., Klein, Teri E.

“…Pharmacogenomics (PGx) investigates the genetic influence on drug response and is an integral part of precision medicine. While PGx testing is becoming more…”
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Predicting new molecular targets for known drugs by Shoichet, Brian K, Roth, Bryan L, Keiser, Michael J, Setola, Vincent, Irwin, John J, Laggner, Christian, Abbas, Atheir I, Hufeisen, Sandra J, Jensen, Niels H, Kuijer, Michael B, Matos, Roberto C, Tran, Thuy B, Whaley, Ryan, Glennon, Richard A, Hert, Jérôme, Thomas, Kelan L. H, Edwards, Douglas D

“…Although drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many…”
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The BioPAX community standard for pathway data sharing by Bader, Gary D, Demir, Emek, Cary, Michael P, Paley, Suzanne, Fukuda, Ken, Lemer, Christian, Vastrik, Imre, Wu, Guanming, D'Eustachio, Peter, Schaefer, Carl, Luciano, Joanne, Schacherer, Frank, Martinez-Flores, Irma, Hu, Zhenjun, Jimenez-Jacinto, Veronica, Joshi-Tope, Geeta, Kandasamy, Kumaran, Lopez-Fuentes, Alejandra C, Mi, Huaiyu, Pichler, Elgar, Rodchenkov, Igor, Splendiani, Andrea, Tkachev, Sasha, Zucker, Jeremy, Gopinath, Gopal, Rajasimha, Harsha, Ramakrishnan, Ranjani, Shah, Imran, Syed, Mustafa, Anwar, Nadia, Babur, Özgün, Blinov, Michael, Brauner, Erik, Corwin, Dan, Donaldson, Sylva, Gibbons, Frank, Goldberg, Robert, Hornbeck, Peter, Luna, Augustin, Murray-Rust, Peter, Neumann, Eric, Reubenacker, Oliver, Samwald, Matthias, van Iersel, Martijn, Wimalaratne, Sarala, Allen, Keith, Braun, Burk, Whirl-Carrillo, Michelle, Cheung, Kei-Hoi, Dahlquist, Kam, Finney, Andrew, Gillespie, Marc, Glass, Elizabeth, Gong, Li, Haw, Robin, Honig, Michael, Hubaut, Olivier, Kane, David, Krupa, Shiva, Kutmon, Martina, Leonard, Julie, Marks, Debbie, Merberg, David, Petri, Victoria, Pico, Alex, Ravenscroft, Dean, Ren, Liya, Shah, Nigam, Sunshine, Margot, Tang, Rebecca, Whaley, Ryan, Letovksy, Stan, Buetow, Kenneth H, Rzhetsky, Andrey, Schachter, Vincent, Sobral, Bruno S, Dogrusoz, Ugur, McWeeney, Shannon, Aladjem, Mirit, Birney, Ewan, Collado-Vides, Julio, Goto, Susumu, Hucka, Michael, Novère, Nicolas Le, Maltsev, Natalia, Pandey, Akhilesh, Thomas, Paul, Wingender, Edgar, Karp, Peter D, Sander, Chris

“…Incompatible data storage formats have hindered the sharing and analyses of digital representations of biological pathways. BioPAX is a standardized language…”
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CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control by Min, Jin-Na, Whaley, Ryan A., Sharpless, Norman E., Lockyer, Pamela, Portbury, Andrea L., Patterson, Cam

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression by Amare, Azmeraw T., Schubert, Klaus Oliver, Tekola-Ayele, Fasil, Hsu, Yi-Hsiang, Sangkuhl, Katrin, Jenkins, Gregory, Whaley, Ryan M., Barman, Poulami, Batzler, Anthony, Altman, Russ B., Arolt, Volker, Brockmöller, Jürgen, Chen, Chia-Hui, Domschke, Katharina, Hall-Flavin, Daniel K., Hong, Chen-Jee, Illi, Ari, Ji, Yuan, Kampman, Olli, Kinoshita, Toshihiko, Leinonen, Esa, Liou, Ying-Jay, Mushiroda, Taisei, Nonen, Shinpei, Skime, Michelle K., Wang, Liewei, Kato, Masaki, Liu, Yu-Li, Praphanphoj, Verayuth, Stingl, Julia C., Bobo, William V., Tsai, Shih-Jen, Kubo, Michiaki, Klein, Teri E., Weinshilboum, Richard M., Biernacka, Joanna M., Baune, Bernhard T.

“…Selective serotonin reuptake inhibitors (SSRIs) are first-line antidepressants for the treatment of major depressive disorder (MDD). However, treatment…”
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P662: Estimating UK Biobank population-specific PGx allele and phenotype frequencies using PharmCAT by Sangkuhl, Katrin, Whaley, Ryan, Woon, Mark, Keat, Karl, Gong, Li, Whirl-Carrillo, Michelle, Ritchie, Marylyn, Klein, Teri

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CHIP activates HSF1 and confers protection against apoptosis and cellular stress by Patterson, Cam, Dai, Qian, Zhang, Chunlian, Wu, Yaxu, McDonough, Holly, Whaley, Ryan A, Godfrey, Virginia, Li, Hui-Hua, Madamanchi, Nageswara, Xu, Wanping, Neckers, Len, Cyr, Douglas

“…Induction of molecular chaperones is the characteristic protective response to environmental stress, and is regulated by a transcriptional program that depends…”
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Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients by Lewis, Joshua P, Backman, Joshua D, Reny, Jean-Luc, Bergmeijer, Thomas O, Mitchell, Braxton D, Ritchie, Marylyn D, Déry, Jean-Pierre, Pakyz, Ruth E, Gong, Li, Ryan, Kathleen, Kim, Eun-Young, Aradi, Daniel, Fernandez-Cadenas, Israel, Lee, Ming Ta Michael, Whaley, Ryan M, Montaner, Joan, Gensini, Gian Franco, Cleator, John H, Chang, Kiyuk, Holmvang, Lene, Hochholzer, Willibald, Roden, Dan M, Winter, Stefan, Altman, Russ B, Alexopoulos, Dimitrios, Kim, Ho-Sook, Gawaz, Meinrad, Bliden, Kevin P, Valgimigli, Marco, Marcucci, Rossella, Campo, Gianluca, Schaeffeler, Elke, Dridi, Nadia P, Wen, Ming-Shien, Shin, Jae Gook, Fontana, Pierre, Giusti, Betti, Geisler, Tobias, Kubo, Michiaki, Trenk, Dietmar, Siller-Matula, Jolanta M, ten Berg, Jurriën M, Gurbel, Paul A, Schwab, Matthias, Klein, Teri E, Shuldiner, Alan R

“…Abstract Aims  Clopidogrel is prescribed for the prevention of atherothrombotic events. While investigations have identified genetic determinants of…”
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Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder by Amare, Azmeraw T, Schubert, Klaus Oliver, Tekola-Ayele, Fasil, Hsu, Yi-Hsiang, Sangkuhl, Katrin, Jenkins, Gregory, Whaley, Ryan M, Barman, Poulami, Batzler, Anthony, Altman, Russ B, Arolt, Volker, Brockmöller, Jürgen, Chen, Chia-Hui, Domschke, Katharina, Hall-Flavin, Daniel K, Hong, Chen-Jee, Illi, Ari, Ji, Yuan, Kampman, Olli, Kinoshita, Toshihiko, Leinonen, Esa, Liou, Ying-Jay, Mushiroda, Taisei, Nonen, Shinpei, Skime, Michelle K, Wang, Liewei, Kato, Masaki, Liu, Yu-Li, Praphanphoj, Verayuth, Stingl, Julia C, Bobo, William V, Tsai, Shih-Jen, Kubo, Michiaki, Klein, Teri E, Weinshilboum, Richard M, Biernacka, Joanna M, Baune, Bernhard T

“…Studies reported a strong genetic correlation between the Big Five personality traits and major depressive disorder (MDD). Moreover, personality traits are…”
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Frequencies of pharmacogenomic alleles across biogeographic groups in a large-scale biobank by Li, Binglan, Sangkuhl, Katrin, Whaley, Ryan, Woon, Mark, Keat, Karl, Whirl-Carrillo, Michelle, Ritchie, Marylyn D., Klein, Teri E.

“…Pharmacogenomics (PGx) is an integral part of precision medicine and contributes to the maximization of drug efficacy and reduction of adverse drug event risk…”
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Life Beyond Kinases: Structure-Based Discovery of Sorafenib as Nanomolar Antagonist of 5-HT Receptors by Lin, Xingyu, Huang, Xi-Ping, Chen, Gang, Whaley, Ryan, Peng, Shiming, Wang, Yanli, Zhang, Guoliang, Wang, Simon X, Wang, Shaohui, Roth, Bryan L, Huang, Niu

“…Of great interest in recent years has been computationally predicting the novel polypharmacology of drug molecules. Here, we applied an “induced-fit” protocol…”
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Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC) by Bergmeijer, Thomas O., Reny, Jean-Luc, Pakyz, Ruth E., Gong, Li, Lewis, Joshua P., Kim, Eun-Young, Aradi, Daniel, Fernandez-Cadenas, Israel, Horenstein, Richard B., Lee, Ming Ta Michael, Whaley, Ryan M., Montaner, Joan, Gensini, Gian Franco, Cleator, John H., Chang, Kiyuk, Holmvang, Lene, Hochholzer, Willibald, Roden, Dan M., Winter, Stefan, Altman, Russ B., Alexopoulos, Dimitrios, Kim, Ho-Sook, Déry, Jean-Pierre, Gawaz, Meinrad, Bliden, Kevin, Valgimigli, Marco, Marcucci, Rossella, Campo, Gianluca, Schaeffeler, Elke, Dridi, Nadia P., Wen, Ming-Shien, Shin, Jae Gook, Simon, Tabassome, Fontana, Pierre, Giusti, Betti, Geisler, Tobias, Kubo, Michiaki, Trenk, Dietmar, Siller-Matula, Jolanta M., ten Berg, Jurriën M., Gurbel, Paul A., Hulot, Jean-Sebastien, Mitchell, Braxton D., Schwab, Matthias, Ritchie, Marylyn DeRiggi, Klein, Teri E., Shuldiner, Alan R.

“…The P2Y12 receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention, or ischemic stroke…”
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PGxMine: Text mining for curation of PharmGKB by Lever, Jake, Barbarino, Julia M, Gong, Li, Huddart, Rachel, Sangkuhl, Katrin, Whaley, Ryan, Whirl-Carrillo, Michelle, Woon, Mark, Klein, Teri E, Altman, Russ B

“…Precision medicine tailors treatment to individuals personal data including differences in their genome. The Pharmacogenomics Knowledgebase (PharmGKB) provides…”
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Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC) by Bergmeijer, Thomas, Reny, Jean-Luc, Pakyz, Ruth, Gong, Li, Lewis, Joshua, Kim, Eun-Young, Aradi, Daniel, Fernandez-Cadenas, Israel, Horenstein, Richard, Lee, Ming Ta Michael, Whaley, Ryan, Montaner, Joan, Gensini, Gian Franco, Cleator, John, Chang, Kiyuk, Holmvang, Lene, Hochholzer, Willibald, Roden, Dan, Winter, Stefan, Altman, Russ, Alexopoulos, Dimitrios, Kim, Ho-Sook, Déry, Jean-Pierre, Gawaz, Meinrad, Bliden, Kevin, Valgimigli, Marco, Marcucci, Rossella, Campo, Gianluca, Schaeffeler, Elke, Dridi, Nadia, Wen, Ming-Shien, Shin, Jae Gook, Simon, Tabassome, Fontana, Pierre, Giusti, Betti, Geisler, Tobias, Kubo, Michiaki, Trenk, Dietmar, Siller-Matula, Jolanta, ten Berg, Jurriën, Gurbel, Paul, Hulot, Jean-Sebastien, Mitchell, Braxton, Schwab, Matthias, Ritchie, Marylyn Deriggi, Klein, Teri, Shuldiner, Alan

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The pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledge by Hernandez-Boussard, Tina, Whirl-Carrillo, Michelle, Hebert, Joan M., Gong, Li, Owen, Ryan, Gong, Mei, Gor, Winston, Liu, Feng, Truong, Chuong, Whaley, Ryan, Woon, Mark, Zhou, Tina, Altman, Russ B., Klein, Teri E.

“…PharmGKB is a knowledge base that captures the relationships between drugs, diseases/phenotypes and genes involved in pharmacokinetics (PK) and…”
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Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical endpoints - Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC) by Bergmeijer, Thomas O., Reny, Jean-Luc, Pakyz, Ruth E., Gong, Li, Lewis, Joshua P., Kim, Eun-Young, Aradi, Daniel, Fernandez-Cadenas, Israel, Horenstein, Richard B., Lee, Ming Ta Michael, Whaley, Ryan M., Montaner, Joan, Gensini, Gian Franco, Cleator, John H., Chang, Kiyuk, Holmvang, Lene, Hochholzer, Willibald, Roden, Dan M., Winter, Stefan, Altman, Russ B., Alexopoulos, Dimitrios, Kim, Ho-Sook, Déry, Jean-Pierre, Gawaz, Meinrad, Bliden, Kevin, Valgimigli, Marco, Marcucci, Rossella, Campo, Gianluca, Schaeffeler, Elke, Dridi, Nadia P., Wen, Ming-Shien, Shin, Jae Gook, Simon, Tabassome, Fontana, Pierre, Giusti, Betti, Geisler, Tobias, Kubo, Michiaki, Trenk, Dietmar, Siller-Matula, Jolanta M., ten Berg, Jurriën M., Gurbel, Paul A., Hulot, Jean-Sebastien, Mitchell, Braxton D., Schwab, Matthias, Ritchie, Marylyn DeRiggi, Klein, Teri E., Shuldiner, Alan R.

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Algorithms for Solving the Discrete Logarithm Problem by Whaley, Ryan

“…In mathematics, there are often many procedures to solve or prove the same problem. The discrete logarithm is one of these problems. The baby step, giant step…”
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Pharmacogenomic Polygenic Response Score Predicts Ischemic Events and Cardiovascular Mortality in Clopidogrel-Treated Patients by Lewis, Joshua P, Backman, Joshua D, Reny, Jean-Luc, Bergmeijer, Thomas O, Mitchell, Braxton D, Ritchie, Marylyn D, Déry, Jean-Pierre, Pakyz, Ruth E, Gong, Li, Ryan, Kathleen, Kim, Eun-Young, Aradi, Daniel, Fernandez-Cadenas, Israel, Lee, Ming Ta Michael, Whaley, Ryan M, Montaner, Joan, Gensini, Gian Franco, Cleator, John H, Chang, Kiyuk, Holmvang, Lene, Hochholzer, Willibald, Roden, Dan M, Winter, Stefan, Altman, Russ, Alexopoulos, Dimitrios, Kim, Ho-Sook, Gawaz, Meinrad, Bliden, Kevin, Valgimigli, Marco, Marcucci, Rossella, Campo, Gianluca, Schaeffeler, Elke, Dridi, Nadia P, Wen, Ming-Shien, Shin, Jae Gook, Fontana, Pierre, Giusti, Betti, Geisler, Tobias, Kubo, Michiaki, Trenk, Dietmar, Siller-Matula, Jolanta M, Ten Berg, Jurriën M, Gurbel, Paul A, Schwab, Matthias, Klein, Teri E, Shuldiner, Alan R

“…Clopidogrel is prescribed for the prevention of atherothrombotic events. While investigations have identified genetic determinants of inter-individual…”
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