Search Results - "Whalen, Kevin M"

In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation by Bi, Yi-An, Kimoto, Emi, Sevidal, Samantha, Jones, Hannah M, Barton, Hugh A, Kempshall, Sarah, Whalen, Kevin M, Zhang, Hui, Ji, Chengjie, Fenner, Katherine S, El-Kattan, Ayman F, Lai, Yurong

“…To assess the feasibility of using sandwich-cultured human hepatocytes (SCHHs) as a model to characterize transport kinetics for in vivo pharmacokinetic…”
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Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes by Kimoto, Emi, Walsky, Robert, Zhang, Hui, Bi, Yi-an, Whalen, Kevin M, Yang, Young-Sun, Linder, Collette, Xiao, Yongling, Iseki, Ken, Fenner, Katherine S, El-Kattan, Ayman F, Lai, Yurong

“…Sandwich-cultured human hepatocytes (SCHH) have been widely used for in vitro assessments of biliary clearance. However, the modulation of metabolism enzymes…”
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A High-Capacity LC/MS System for the Bioanalysis of Samples Generated from Plate-Based Metabolic Screening by Janiszewski, John S, Rogers, Katrina J, Whalen, Kevin M, Cole, Mark J, Liston, Theodore E, Duchoslav, Eva, Fouda, Hassan G

“…HPLC/MS is a linear technique characterized by serial injection and analysis of individual samples. Parallel-format high-throughput screens for druglike…”
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pH-Sensitive Interaction of HMG-CoA Reductase Inhibitors (Statins) with Organic Anion Transporting Polypeptide 2B1 by Varma, Manthena V, Rotter, Charles J, Chupka, Jonathan, Whalen, Kevin M, Duignan, David B, Feng, Bo, Litchfield, John, Goosen, Theunis C, El-Kattan, Ayman F

“…The human organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) is ubiquitously expressed and may play an important role in the disposition of…”
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High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models by Hop, Cornelis E C A, Cole, Mark J, Davidson, Ralph E, Duignan, David B, Federico, James, Janiszewski, John S, Jenkins, Kelly, Krueger, Suzanne, Lebowitz, Rebecca, Liston, Theodore E, Mitchell, Walter, Snyder, Mark, Steyn, Stefan J, Soglia, John R, Taylor, Christine, Troutman, Matt D, Umland, John, West, Michael, Whalen, Kevin M, Zelesky, Veronica, Zhao, Sabrina X

“…Evaluation and optimization of drug metabolism and pharmacokinetic data plays an important role in drug discovery and development and several reliable in vitro…”
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AutoScan: an automated workstation for rapid determination of mass and tandem mass spectrometry conditions for quantitative bioanalytical mass spectrometry by Whalen, Kevin M., Rogers, Katrina J., Cole, Mark J., Janiszewski, John S.

“…An automated flow injection analysis (FIA) mass spectrometry system (AutoScan) was developed to allow rapid unattended determination of optimal conditions…”
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