Search Results - "Weytjens, Bram"
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Network-Based Identification of Adaptive Pathways in Evolved Ethanol-Tolerant Bacterial Populations
Published in Molecular biology and evolution (01-11-2017)“…Efficient production of ethanol for use as a renewable fuel requires organisms with a high level of ethanol tolerance. However, this trait is complex and…”
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Image-Based Dynamic Phenotyping Reveals Genetic Determinants of Filamentation-Mediated β-Lactam Tolerance
Published in Frontiers in microbiology (13-03-2020)“…Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance…”
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Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa
Published in PloS one (11-05-2016)“…Nosocomial and community-acquired infections caused by multidrug resistant bacteria represent a major human health problem. Thus, there is an urgent need for…”
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1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage
Published in Frontiers in microbiology (08-02-2018)“…The ever increasing multidrug-resistance of clinically important pathogens and the lack of novel antibiotics have resulted in a true antibiotic crisis where…”
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OMEN: network-based driver gene identification using mutual exclusivity
Published in Bioinformatics (13-06-2022)“…Abstract Motivation Network-based driver identification methods that can exploit mutual exclusivity typically fail to detect rare drivers because of their…”
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SSA-ME Detection of cancer driver genes using mutual exclusivity by small subnetwork analysis
Published in Scientific reports (03-11-2016)“…Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is…”
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IAMBEE: a web-service for the identification of adaptive pathways from parallel evolved clonal populations
Published in Nucleic acids research (02-07-2019)“…IAMBEE is a web server designed for the Identification of Adaptive Mutations in Bacterial Evolution Experiments (IAMBEE). Input data consist of genotype…”
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Network-Based Analysis of eQTL Data to Prioritize Driver Mutations
Published in Genome biology and evolution (01-03-2016)“…In clonal systems, interpreting driver genes in terms of molecular networks helps understanding how these drivers elicit an adaptive phenotype. Obtaining such…”
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PheNetic: network-based interpretation of molecular profiling data
Published in Nucleic acids research (01-07-2015)“…Molecular profiling experiments have become standard in current wet-lab practices. Classically, enrichment analysis has been used to identify biological…”
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Molecular processes underlying synergistic linuron mineralization in a triple‐species bacterial consortium biofilm revealed by differential transcriptomics
Published in MicrobiologyOpen (Weinheim) (01-04-2018)“…The proteobacteria Variovorax sp. WDL1, Comamonas testosteroni WDL7, and Hyphomicrobium sulfonivorans WDL6 compose a triple‐species consortium that…”
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