Search Results - "Weyer, Andy D"

Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling by Moehring, Francie, Cowie, Ashley M, Menzel, Anthony D, Weyer, Andy D, Grzybowski, Michael, Arzua, Thiago, Geurts, Aron M, Palygin, Oleg, Stucky, Cheryl L

“…The first point of our body's contact with tactile stimuli (innocuous and noxious) is the epidermis, the outermost layer of skin that is largely composed of…”
Get full text

Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity by Chiu, Isaac M, Barrett, Lee B, Williams, Erika K, Strochlic, David E, Lee, Seungkyu, Weyer, Andy D, Lou, Shan, Bryman, Gregory S, Roberson, David P, Ghasemlou, Nader, Piccoli, Cara, Ahat, Ezgi, Wang, Victor, Cobos, Enrique J, Stucky, Cheryl L, Ma, Qiufu, Liberles, Stephen D, Woolf, Clifford J

“…The somatosensory nervous system is critical for the organism's ability to respond to mechanical, thermal, and nociceptive stimuli. Somatosensory neurons are…”
Get full text

Loosening Pain’s Grip by Tightening TRPV1-TRPA1 Interactions by Weyer, Andy D., Stucky, Cheryl L.

“…TRPA1 and TRPV1 are ion channels crucial for pain sensation. In this issue of Neuron, Weng et al. (2015) demonstrate that the activity of TRPA1-TRPV1…”
Get full text

Mechanosensory and ATP Release Deficits following Keratin14-Cre-Mediated TRPA1 Deletion Despite Absence of TRPA1 in Murine Keratinocytes by Zappia, Katherine J, Garrison, Sheldon R, Palygin, Oleg, Weyer, Andy D, Barabas, Marie E, Lawlor, Michael W, Staruschenko, Alexander, Stucky, Cheryl L

“…Keratinocytes are the first cells that come into direct contact with external tactile stimuli; however, their role in touch transduction in vivo is not clear…”
Get full text

Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats by Lehto, Sonya G, Weyer, Andy D, Youngblood, Beth D, Zhang, Maosheng, Yin, Ruoyuan, Wang, Weiya, Teffera, Yohannes, Cooke, Melanie, Stucky, Cheryl L, Schenkel, Laurie, Geuns-Meyer, Stephanie, Moyer, Bryan D, Wild, Kenneth D, Gavva, Narender R

“…The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in pathophysiological processes that include asthma, cough, and inflammatory…”
Get full text

Piezo2 is required for Merkel-cell mechanotransduction by Woo, Seung-Hyun, Ranade, Sanjeev, Weyer, Andy D., Dubin, Adrienne E., Baba, Yoshichika, Qiu, Zhaozhu, Petrus, Matt, Miyamoto, Takashi, Reddy, Kritika, Lumpkin, Ellen A., Stucky, Cheryl L., Patapoutian, Ardem

“…A mouse study shows that non-neuronal epidermal Merkel cells aid fine-touch perception in the skin through their expression of the Piezo2 mechanosensitive…”
Get full text

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain by Osteen, Jeremiah D., Herzig, Volker, Gilchrist, John, Emrick, Joshua J., Zhang, Chuchu, Wang, Xidao, Castro, Joel, Garcia-Caraballo, Sonia, Grundy, Luke, Rychkov, Grigori Y., Weyer, Andy D., Dekan, Zoltan, Undheim, Eivind A. B., Alewood, Paul, Stucky, Cheryl L., Brierley, Stuart M., Basbaum, Allan I., Bosmans, Frank, King, Glenn F., Julius, David

“…Voltage-gated sodium (Na v ) channels initiate action potentials in most neurons, including primary afferent nerve fibres of the pain pathway. Local…”
Get full text

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine by Weyer, Andy D, Lehto, Sonya G

“…A review. Development of pharmaceutical antagonists of transient receptor potential melastatin 8 (TRPM8) have been pursued for the treatment of chronic pain…”
Get full text

Repurposing a leukocyte elastase inhibitor for neuropathic pain by Weyer, Andy D, Stucky, Cheryl L

“…Neuropathic pain is a debilitating condition affecting millions of people worldwide. A new study investigates mechanisms of neuropathic pain initiation and…”
Get full text

Chemokine (c-c motif) receptor 2 mediates mechanical and cold hypersensitivity in sickle cell disease mice by Sadler, Katelyn E., Zappia, Katherine J., O'Hara, Crystal L., Langer, Sarah N., Weyer, Andy D., Hillery, Cheryl A., Stucky, Cheryl L.

“…Approximately one-third of individuals with sickle cell disease (SCD) develop chronic pain. This debilitating pain is inadequately treated because the…”
Get full text

A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons by Garrison, Sheldon R., Weyer, Andy D., Barabas, Marie E., Beutler, Bruce A., Stucky, Cheryl L.

“…Gain-of-function mutation in Nav1.8 channel produces its most marked effect along the axon, resulting in intense spontaneous bursting and increased…”
Get full text

Amplified Mechanically Gated Currents in Distinct Subsets of Myelinated Sensory Neurons following In Vivo Inflammation of Skin and Muscle by Weyer, Andy D, O'Hara, Crystal L, Stucky, Cheryl L

“…Primary afferents are sensitized to mechanical stimuli following in vivo inflammation, but whether sensitization of mechanically gated ion channels contributes…”
Get full text

AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia by Lehto, Sonya G., Weyer, Andy D., Zhang, Maosheng, Youngblood, Beth D., Wang, Judy, Wang, Weiya, Kerstein, Patrick C., Davis, Carl, Wild, Kenneth D., Stucky, Cheryl L., Gavva, Narender R.

“…TRPM8 has been implicated in pain and migraine based on dorsal root- and trigeminal ganglion-enriched expression, upregulation in preclinical models of pain,…”
Get full text

Corticomotor Excitability During a Noxious Stimulus Before and After Exercise in Women With Fibromyalgia by Hoeger Bement, Marie K, Weyer, Andy D, Yoon, Tejin, Hunter, Sandra K

“…The purposes of this study were to assess corticomotor excitability in people with fibromyalgia during a noxious stimulus before and after fatiguing exercise…”
Get full text

Nociceptor Sensitization Depends on Age and Pain Chronicity(1,2,3) by Weyer, Andy D, Zappia, Katherine J, Garrison, Sheldon R, O'Hara, Crystal L, Dodge, Amanda K, Stucky, Cheryl L

“…Peripheral inflammation causes mechanical pain behavior and increased action potential firing. However, most studies examine inflammatory pain at acute, rather…”
Get full text

Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity by Chiu, Isaac M, Barrett, Lee B, Williams, Erika K, Strochlic, David E, Lee, Seungkyu, Weyer, Andy D, Lou, Shan, Bryman, Gregory, Roberson, David P, Ghasemlou, Nader, Piccoli, Cara, Ahat, Ezgi, Wang, Victor, Cobos, Enrique J, Stucky, Cheryl L, Ma, Qiufu, Liberles, Stephen D, Woolf, Clifford

“…Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EH, Stucky CL, Ma…”
Get full text

Amplified Mechanically Gated Currents in Distinct Subsets of Myelinated Sensory Neurons following In Vivo Inflammation of Skin and Muscle by Weyer, Andy D, O'Hara, Crystal L, Stucky, Cheryl L

“…Primary afferents are sensitized to mechanical stimuli following in vivo inflammation, but whether sensitization of mechanically gated ion channels contributes…”
Get full text

Selective spider toxins reveal a role for the [Na.sub.v]1.1 channel in mechanical pain by Osteen, Jeremiah D, Herzig, Volker, Gilchrist, John, Emrick, Joshua J, Zhang, Chuchu, Wang, Xidao, Castro, Joel, Garcia-caraballo, Sonia, Grundy, Luke, Rychkov, Grigori Y, Weyer, Andy D, Dekan, Zoltan, Undheim, Eivind A.B, Alewood, Paul, Stucky, cheryl L, Brierley, Stuart M, Basbaum, Allan i, Bosmans, Frank, King, Glenn F, Julius, David

“…Voltage-gated sodium ([Na.sub.v]) channels initiate action potentials in most neurons, including primary afferent nerve fibres of the pain pathway. Local…”
Get full text

Selective spider toxins reveal a role for the Na^sub v^1.1 channel in mechanical pain by Osteen, Jeremiah D, Herzig, Volker, Gilchrist, John, Emrick, Joshua J, Zhang, Chuchu, Wang, Xidao, Castro, Joel, Garcia-Caraballo, Sonia, Grundy, Luke, Rychkov, Grigori Y, Weyer, Andy D, Dekan, Zoltan, Undheim, Eivind A B, Alewood, Paul, Stucky, Cheryl L, Brierley, Stuart M, Basbaum, Allan I, Bosmans, Frank, King, Glenn F, Julius, David

“…Voltage-gated sodium (Na^sub v^) channels initiate action potentials in most neurons, including primary afferent nerve fibres of the pain pathway. Local…”
Get full text

Piezo2 is required forMerkel-cellmechanotransduction by Woo, Seung-Hyun, Ranade, Sanjeev, Weyer, Andy D, Dubin, Adrienne E, Baba, Yoshichika, Qiu, Zhaozhu, Petrus, Matt, Miyamoto, Takashi, Reddy, Kritika, Lumpkin, Ellen A, Stucky, Cheryl L, Patapoutian, Ardem

“…How we sense touch remains fundamentally unknown. The Merkel cell-neurite complex is a gentle touch receptor in the skin that mediates slowly adapting…”
Get full text