Search Results - "Wexelblatt, Scott L"
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Cohort Analysis of a Pharmacokinetic-Modeled Methadone Weaning Optimization for Neonatal Abstinence Syndrome
Published in The Journal of pediatrics (01-12-2015)“…Objective To evaluate neonatal abstinence syndrome (NAS) treatment outcomes achieved using an optimized methadone weaning protocol developed using…”
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A Cohort Comparison of Buprenorphine versus Methadone Treatment for Neonatal Abstinence Syndrome
Published in The Journal of pediatrics (01-03-2016)“…Objectives To compare the duration of opioid treatment and length of stay among infants treated for neonatal abstinence syndrome (NAS) by using a pilot…”
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Forecasting Fetal Buprenorphine Exposure through Maternal-Fetal Physiologically Based Pharmacokinetic Modeling
Published in Pharmaceutics (01-03-2024)“…Buprenorphine readily crosses the placenta, and with greater prenatal exposure, neonatal opioid withdrawal syndrome (NOWS) likely grows more severe. Current…”
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Universal Maternal Drug Testing in a High-Prevalence Region of Prescription Opiate Abuse
Published in The Journal of pediatrics (01-03-2015)“…Objective To evaluate the efficacy of a universal maternal drug testing protocol for all mothers in a community hospital setting that experienced a 3-fold…”
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A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome
Published in Pharmacology & therapeutics (Oxford) (01-06-2022)“…Physiologically-based pharmacokinetic (PBPK) modeling has emerged as a useful tool to study pharmacokinetics (PK) in special populations, such as pregnant…”
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A multicenter cohort study of treatments and hospital outcomes in neonatal abstinence syndrome
Published in Pediatrics (Evanston) (01-08-2014)“…To compare pharmacologic treatment strategies for neonatal abstinence syndrome (NAS) with respect to total duration of opioid treatment and length of inpatient…”
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Developmental Disorders and Medical Complications Among Infants with Subclinical Intrauterine Opioid Exposures
Published in Population health management (01-02-2019)“…The objective was to compare diagnosis rates representing developmental outcomes and medical complications between infants with intrauterine opioid exposures…”
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Subclinical and Overt Newborn Opioid Exposure: Prevalence and First-Year Healthcare Utilization
Published in The Journal of pediatrics (01-07-2020)“…To categorize newborn infants in Hamilton County, Ohio by late pregnancy fetal opioid exposure status and to assess their first-year healthcare utilization. We…”
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Implementation of a Neonatal Abstinence Syndrome Weaning Protocol: A Multicenter Cohort Study
Published in Pediatrics (Evanston) (01-10-2015)“…To evaluate the generalizability of stringent protocol-driven weaning in improving total duration of opioid treatment and length of inpatient hospital stay…”
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Physiologically‐Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome
Published in Clinical pharmacology and therapeutics (01-02-2022)“…Neonatal opioid withdrawal syndrome (NOWS) is a major public health concern whose incidence has paralleled the opioid epidemic in the United States. Sublingual…”
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Racial Inequities in Breastfeeding Counseling Among Pregnant People Who Use Cannabis
Published in Obstetrics and gynecology (New York. 1953) (01-11-2022)“…We examined how breastfeeding advice in the context of cannabis use differed by race and ethnicity. Data from the 2017–2018 PRAMS (Pregnancy Risk Assessment…”
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Rates of substance and polysubstance use through universal maternal testing at the time of delivery
Published in Journal of perinatology (01-08-2022)“…Objective To report substance and polysubstance use at the time of delivery. Study design A cross-sectional study was performed on mothers consented for…”
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Pharmacotherapy of neonatal opioid withdrawal syndrome: a review of pharmacokinetics and pharmacodynamics
Published in Expert opinion on drug metabolism & toxicology (02-01-2021)“…Neonatal opioid withdrawal syndrome (NOWS) often arises in infants born to mothers who used opioids during pregnancy. Morphine, methadone, and buprenorphine…”
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Opioid Neonatal Abstinence Syndrome: An Overview
Published in Clinical pharmacology and therapeutics (01-06-2018)“…Opioid neonatal abstinence syndrome (NAS) refers to signs of withdrawal observed in infants experiencing intrauterine opioid exposures. Early identification of…”
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Regional comparison of self-reported late pregnancy cigarette smoking to mass spectrometry analysis
Published in Journal of perinatology (01-10-2021)“…Objective To report a more accurate prevalence estimate of late pregnancy nicotine exposures. Study design A cross-sectional study during a 2-month period in…”
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16
Torticollis in Infants with a History of Neonatal Abstinence Syndrome
Published in The Journal of pediatrics (01-05-2018)“…In this retrospective cohort study, we assessed the incidence of torticollis in infants with a history of neonatal abstinence syndrome. Understanding the…”
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Comparison of Neonatal Abstinence Syndrome Treatment with Sublingual Buprenorphine versus Conventional Opioids
Published in American journal of perinatology (01-03-2018)“…The objective of this study was to compare duration of opioid treatment and length of stay outcomes for neonatal abstinence syndrome (NAS) using sublingual…”
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Addressing the Disease Burden of Vertically Acquired Hepatitis C Virus Infection Among Opioid-Exposed Infants
Published in Open forum infectious diseases (01-12-2019)“…This study aims to estimate the disease burden of vertically acquired hepatitis C virus (HCV) in a large Midwestern hospital and to identify factors associated…”
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Care Coordination Associated with Improved Timing of Newborn Primary Care Visits
Published in Maternal and child health journal (01-09-2016)“…Objective Despite practice recommendations that all newborns be examined within 3–5 days after discharge, many are not seen within this timeframe. Our…”
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Design considerations for point-of-care clinical trials comparing methadone and buprenorphine treatment for opioid dependence in pregnancy and for neonatal abstinence syndrome
Published in Contemporary clinical trials (01-09-2014)“…Abstract Rationale In recent years, the U.S. has experienced a significant increase in the prevalence of pregnant opioid-dependent women and of neonatal…”
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