Search Results - "Wetzel, Michael D."

The identification and characterization of breast cancer CTCs competent for brain metastasis by Zhang, Lixin, Ridgway, Lon D, Wetzel, Michael D, Ngo, Jason, Yin, Wei, Kumar, Disha, Goodman, Jerry C, Groves, Morris D, Marchetti, Dario

“…Brain metastatic breast cancer (BMBC) is uniformly fatal and increasing in frequency. Despite its devastating outcome, mechanisms causing BMBC remain largely…”
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Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia-reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis by Wetzel, Michael D, Wenke, Joseph C

“…Ischemia-reperfusion injury is caused by a period of ischemia followed by massive blood flow into a tissue that had experienced restricted blood flow. The…”
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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice by Neelakantan, Harshini, Vance, Virginia, Wetzel, Michael D., Wang, Hua-Yu Leo, McHardy, Stanton F., Finnerty, Celeste C., Hommel, Jonathan D., Watowich, Stanley J.

“…[Display omitted] There is a critical need for new mechanism-of-action drugs that reduce the burden of obesity and associated chronic metabolic comorbidities…”
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Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer by Zhang, Lixin, Ngo, Jason A, Wetzel, Michael D, Marchetti, Dario

“…Abstract Heparanase (HPSE) is the dominant mammalian endoglycosidase and important tumorigenic, angiogenic, and pro-metastatic molecule. Highest levels of HPSE…”
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disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization by Liu, Meilian, Zhou, Lijun, Xu, Aimin, Lam, Karen S.L, Wetzel, Michael D, Xiang, Ruihua, Zhang, Jingjing, Xin, Xiaoban, Dong, Lily Q, Liu, Feng

“…Impairments in adiponectin multimerization lead to defects in adiponectin secretion and function and are associated with diabetes, yet the underlying…”
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Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1 by Wang, Changhua, Mao, Xuming, Wang, Lixin, Liu, Meilian, Wetzel, Michael D., Guan, Kun-Liang, Dong, Lily Q., Liu, Feng

“…Adiponectin functions as an insulin sensitizer, and yet the underlying molecular mechanism(s) remains largely unknown. We found that treating C2C12 myotubes…”
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Homoarginine ameliorates diabetic nephropathy independent of nitric oxide synthase‐3 by Wetzel, Michael D., Stanley, Kristen, Maity, Soumya, Madesh, Muniswamy, Bopassa, Jean C., Awad, Alaa S.

“…Recently we showed that homoarginine supplementation confers kidney protection in diabetic mouse models. In this study we tested whether the protective effect…”
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l‐Homoarginine supplementation prevents diabetic kidney damage by Wetzel, Michael D., Gao, Ting, Venkatachalam, Manjeri, Morris, Sidney M., Awad, Alaa S.

“…l‐homoarginine is an endogenous, non‐proteinogenic amino acid that has emerged as a new player in health and disease. Specifically, low l‐homoarginine levels…”
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Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells by Ridgway, Lon D, Wetzel, Michael D, Ngo, Jason A, Erdreich-Epstein, Anat, Marchetti, Dario

“…Heparanase is the only mammalian endoglycosidase which has been widely implicated in cancer because of its capability to degrade heparan sulfate chains of…”
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Modulation of GEF-H1 Induced Signaling by Heparanase in Brain Metastatic Melanoma Cells by Ridgway, Lon D., Wetzel, Michael D., Marchetti, Dario

“…Mechanisms of brain metastatic melanoma (BMM) remain largely unknown. Understanding the modulation of signaling pathways that alter BMM cell invasion and…”
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Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis by Wetzel, Michael D, Stanley, Kristen, Wang, Wei Wei, Maity, Soumya, Madesh, Muniswamy, Reeves, W Brian, Awad, Alaa S

“…Fibrosis is the final common pathway in the pathophysiology of most forms of chronic kidney disease (CKD). As treatment of renal fibrosis still remains largely…”
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Pontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression by Tang, Dan, Zhang, Zhao, Zboril, Emily, Wetzel, Michael D., Xu, Xinping, Zhang, Wei, Chen, Lizhen, Liu, Zhijie

“…[Display omitted] •Pontin is an essential gene but its function is not fully understood.•ChIP-seq identified genome-wide binding sites of Pontin in response to…”
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Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy by Wetzel, Michael D, Gao, Ting, Stanley, Kristen, Cooper, Timothy K, Morris, Jr, Sidney M, Awad, Alaa S

“…Endothelial dysfunction, characterized by reduced bioavailability of nitric oxide and increased oxidative stress, is a hallmark characteristic in diabetes and…”
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Characterization of Adipose-Derived Stem Cells Following Burn Injury by Prasai, Anesh, El Ayadi, Amina, Mifflin, Randy C., Wetzel, Michael D., Andersen, Clark R., Redl, Heinz, Herndon, David N., Finnerty, Celeste C.

“…Severe burns induce a prolonged inflammatory response in subcutaneous adipose tissue that modulates signaling in adipose-derived stem cells (ASCs), which hold…”
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Absence of CCR2 results in an inflammaging environment in young mice with age‐independent impairments in muscle regeneration by Melton, David W., Roberts, Alexander C., Wang, Hanzhou, Sarwar, Zaheer, Wetzel, Michael D., Wells, Jason T., Porter, Laurel, Berton, Michael T., McManus, Linda M., Shireman, Paula K.

“…CCR2 KO has impaired myeloid recruitment, regeneration, and failure of regenerated myofibers to attain baseline size despite increased tissue…”
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Heparanase modulates Shh and Wnt3a signaling in human medulloblastoma cells by RIDGWAY, LON D, WETZEL, MICHAEL D, MARCHETTI, DARIO

“…The pathogenesis of medulloblastoma (MB), the most common and aggressive brain tumor in children, is poorly understood. MB tumors respond to factors secreted…”
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92. Environmental Factors Determine In Vivo Myogenic Progenitor Cell Function by Sun, Dongxu, Wetzel, Michael D, Waite, Lindsay L, Michalek, Joel E, McManus, Linda M, Shireman, Paula K

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P8. Environmental Factors Determine in Vivo Myogenic Progenitor Cell Function by Sun, Dongxu, Wetzel, Michael D, Waite, Lindsay L, Michalek, Joel E, McManus, Linda M, Shireman, Paula K

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Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer12 by Zhang, Lixin, Ngo, Jason A., Wetzel, Michael D., Marchetti, Dario

“…Heparanase (HPSE) is the dominant mammalian endoglycosidase and important tumorigenic, angiogenic, and pro-metastatic molecule. Highest levels of HPSE activity…”
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A solder-free interconnect approach for integrating millimeter wave high-power devices with planar circuitry by Choudhury, D., Lawyer, P.H., Foschaar, J.A., Wetzel, M.D., Rensch, D.B.

“…The development of commercial millimeter wave systems requires cost-effective, high-performance device/circuit assembly techniques. A solder-free thermosonic…”
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