Search Results - "Wetzel, Hanna"

Differential effects of acute and chronic antagonist and an irreversible antagonist treatment on cocaine self-administration behavior in rats by Wetzel, Hanna N., Tsibulsky, Vladimir L., Norman, Andrew B.

“…According to pharmacological theory, the magnitude of an agonist-induced response is related to the number of receptors occupied. If there is a receptor…”
Get full text

The compulsion zone explains the self-administration of cocaine, RTI-55 and bupropion in rats by Zinani, Dakota B., Wetzel, Hanna N., Norman, Andrew B.

“…•The rate of consumption of these drugs varies by ∼ 348 fold.•Rate of consumption of each drug is the product of the relative t1/2 and relative satiety…”
Get full text

A novel differential scanning fluorimetry analysis of a humanized anti-cocaine mAb and its ligand binding characteristics by Kirley, Terence L., Norman, Andrew B., Wetzel, Hanna N.

“…An anti-cocaine monoclonal antibody (mAb) designated h2E2 will soon enter clinical trials for the treatment of cocaine abuse disorders. Importantly, this…”
Get full text

Student perceptions of scientific writing in pharmacology: Student generation of collaborative rubrics to score a social pharmacology writing project by Enslein, Terri, Kosack, Edward, Wetzel, Hanna N.

“…Scholarly writing is an important skill in all fields of study. Despite a strong focus on writing in many courses, faculty and students have disparate…”
Get full text

A mathematical model of a recombinant humanized anti-cocaine monoclonal antibody's effects on cocaine pharmacokinetics in mice by Wetzel, Hanna N., Zhang, Tongli, Norman, Andrew B.

“…A recombinant humanized anti-cocaine monoclonal antibody (mAb), h2E2, is at an advanced stage of pre-clinical development as an immunotherapy for cocaine…”
Get full text

Effects of a Recombinant Humanized Anti‐Cocaine Monoclonal Antibody on the Metabolism and Distribution of Cocaine In Vitro and in Mice by Zinani, Dakota B., Turner, Mackenzie E., Wetzel, Hanna N., Crutchfield, Christopher A., Norman, Andrew B.

“…The anti‐cocaine monoclonal antibody (mAb), h2E2, is a candidate for treating cocaine‐use disorder. h2E2 binds to and sequesters cocaine in the plasma…”
Get full text

The effects of a repeated dose of a recombinant humanized anti-cocaine monoclonal antibody on cocaine self-administration in rats by Wetzel, Hanna N, Tsibulsky, Vladimir L, Norman, Andrew B

“…Highlights • The effects of two infusions of h2E2 on self-administration behavior were tested. • h2E2 increased the cocaine priming threshold following both…”
Get full text

A Recombinant Humanized Anticocaine Monoclonal Antibody Alters the Urinary Clearance of Cocaine and Its Metabolites in Rats by Marckel, Jordan A, Wetzel, Hanna N, Amlal, Sihame, Amlal, Hassane, Norman, Andrew B

“…A recombinant humanized anticocaine monoclonal antibody, h2E2, has shown potential in the preclinical phases for the treatment of cocaine abuse. The standard…”
Get full text

Characterization of a recombinant humanized anti-cocaine monoclonal antibody produced from multiple clones for the selection of a master cell bank candidate by Wetzel, Hanna N., Webster, Rose P., Saeed, Fatima O., Kirley, Terence L., Ball, William J., Norman, Andrew B.

“…We have generated a humanized anti-cocaine monoclonal antibody (mAb), which is at an advanced stage of pre-clinical development. We report here in vitro…”
Get full text

Analysis of Cell-Cell Bridges in Haloferax volcanii Using Electron Cryo-Tomography Reveal a Continuous Cytoplasm and S-Layer by Sivabalasarma, Shamphavi, Wetzel, Hanna, Nußbaum, Phillip, van der Does, Chris, Beeby, Morgan, Albers, Sonja-Verena

“…Halophilic archaea have been proposed to exchange DNA and proteins using a fusion-based mating mechanism. Scanning electron microscopy previously suggested…”
Get full text

A novel Python program for implementation of quality control in the ELISA by Wetzel, Hanna N., Cohen, Cinder, Norman, Andrew B., Webster, Rose P.

“…The use of semi-quantitative assays such as the enzyme-linked immunosorbent assay (ELISA) requires stringent quality control of the data. However, such quality…”
Get full text

Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice by Turner, Mackenzie E., Wetzel, Hanna N., Zinani, Dakota B., Crutchfield, Christopher A., Norman, Andrew B.

“…The anti‐cocaine monoclonal antibody, h2E2, is a candidate for treating cocaine‐use disorder. h2E2 binds to and sequesters cocaine in the plasma compartment,…”
Get full text

The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition of cocaethylene in mice by Wetzel, Hanna N., Tabet, Michael R., Ball, William J., Norman, Andrew B.

“…The chimeric human/mouse anti-cocaine monoclonal antibody (mAb) 2E2 and its further humanized variant h2E2 have been reported to sequester a significant…”
Get full text

Evaluation of methods to reduce background using the Python-based ELISA_QC program by Webster, Rose P., Cohen, Cinder F., Saeed, Fatima O., Wetzel, Hanna N., Ball, William J., Kirley, Terence L., Norman, Andrew B.

“…Almost all immunological approaches [immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), Western blot], that are used to quantitate specific…”
Get full text

An Interactive Jupyter Notebook for Teaching the Foundational Mathematical Basis of Compartmental Pharmacokinetics by Wetzel, Hanna

“…Pharmacokinetics is often taught as two different lessons, the foundational mathematical basis and the clinical application. Due to the lack of hands‐on…”
Get full text

Cytotoxicity and apoptotic gene expression in an in vitro model of the blood-brain barrier following exposure to poly(butylcyanoacrylate) nanoparticles by Hall, Andrew M., Hemmer, Ruth, Spaulding, Robert, Wetzel, Hanna N., Curcio, Joseph, Sabel, Bernhard A., Henrich-Noack, Petra, Pixley, Sarah, Hopkins, Tracy, Boyce, Richard L., Schultheis, Patrick J., Haik, Kristi L.

“…Background Poly(butylcyanoacrylate) (PBCA) nanoparticles (NPs) loaded with doxorubicin (DOX) and coated with polysorbate 80 (PS80) have shown efficacy in the…”
Get full text

Characterizing the role of D 2 –like dopamine receptors in cocaine self‐administration in rats by Verduguez, Randy Edgar, Wetzel, Hanna, Norman, Andrew

“…Abstract only Both D 1 –like and D 2 –like dopamine receptor families appear to be involved in cocaine self‐administration behavior, but the ability of…”
Get full text

The Effect of a Humanized Anti‐Cocaine Monoclonal Antibody on the In Vitro Metabolism of Cocaine by Turner, Mackenzie E., Crutchfield, Christopher A., Bell-Horwath, Tiffany R., Wetzel, Hanna N., Norman, Andrew B.

“…Abstract only The humanized anti‐cocaine monoclonal antibody (mAb) h2E2 is a lead candidate for treating cocaine‐use disorders and relapse. When cocaine binds…”
Get full text

Compulsion zone theory of the self‐administration paradigm explains different drug durations of extinction responding with different cocaine analogues by Zinani, Dakota B., Wetzel, Hanna N., Tsibulsky, Vladimir L., Norman, Andrew B.

“…Abstract only The compulsion zone theory of cocaine self‐administration states that lever‐pressing behavior is a drug‐induced behavior that is induced only…”
Get full text

Early-life caffeine exposure induces morphological changes and altered physiology in Caenorhabditis elegans by Kuo-Esser, Lance, Chen, Ramon, Lawson, Kylie, Kuchinski, Kennedy, Simmons, Nijah, Dominguez, Mauricio, Scandura, Tommy, Vo, Martin, Dasenbrock-Gammon, Emma, Hagan, Natalie, Esposito, Haley, Thompson, Molly, Le, Steven, Escorcia, Wilber, Wetzel, Hanna N.

Get full text