Search Results - "Wetzel, H."

The Role of Chemokines in the Pathophysiology of Major Depressive Disorder by Milenkovic, Vladimir M, Stanton, Evan H, Nothdurfter, Caroline, Rupprecht, Rainer, Wetzel, Christian H

“…Major depressive disorder (MDD) is a debilitating condition, whose high prevalence and multisymptomatic nature set its standing as a leading contributor to…”
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Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells by Bader, Stefanie, Wolf, Luisa, Milenkovic, Vladimir M., Gruber, Michael, Nothdurfter, Caroline, Rupprecht, Rainer, Wetzel, Christian H.

“…[Display omitted] •Pregnenolone biosynthesis in BV-2 microglia cells is dependent on TSPO expression.•The TSPO ligands XBD173 and Ro 5-4864 stimulate…”
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Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders? by Rupprecht, Rainer, Wetzel, Christian H., Dorostkar, Mario, Herms, Jochen, Albert, Nathalie L., Schwarzbach, Jens, Schumacher, Michael, Neumann, Inga D.

“…Efficient treatment of stress-related disorders, such as depression, is still a major challenge. The onset of antidepressant drug action is generally quite…”
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Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation by Pozzo, Eleonora Da, Tremolanti, Chiara, Costa, Barbara, Giacomelli, Chiara, Milenkovic, Vladimir M, Bader, Stefanie, Wetzel, Christian H, Rupprecht, Rainer, Taliani, Sabrina, Settimo, Federico Da, Martini, Claudia

“…A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation has been recently proposed. However, little is known about…”
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Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation by Geissler, Maren, Gottschling, Christine, Aguado, Ainhara, Rauch, Uwe, Wetzel, Christian H, Hatt, Hanns, Faissner, Andreas

“…The extracellular matrix (ECM) of the brain plays crucial roles during the development, maturation, and regeneration of the CNS. In a subpopulation of neurons,…”
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Microstructures in landslides in northwest China – Implications for creeping displacements? by Schäbitz, M., Janssen, C., Wenk, H.-R., Wirth, R., Schuck, B., Wetzel, H.-U., Meng, X., Dresen, G.

“…Microstructures, mineralogical composition and texture of selected landslide samples from three landslides in the southern part of the Gansu Province (China)…”
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Deep sequencing of the murine olfactory receptor neuron transcriptome by Kanageswaran, Ninthujah, Demond, Marilen, Nagel, Maximilian, Schreiner, Benjamin S P, Baumgart, Sabrina, Scholz, Paul, Altmüller, Janine, Becker, Christian, Doerner, Julia F, Conrad, Heike, Oberland, Sonja, Wetzel, Christian H, Neuhaus, Eva M, Hatt, Hanns, Gisselmann, Günter

“…The ability of animals to sense and differentiate among thousands of odorants relies on a large set of olfactory receptors (OR) and a multitude of accessory…”
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Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells by Milenkovic, Andrea, Brandl, Caroline, Milenkovic, Vladimir M., Jendryke, Thomas, Sirianant, Lalida, Wanitchakool, Potchanart, Zimmermann, Stephanie, Reiff, Charlotte M., Horling, Franziska, Schrewe, Heinrich, Schreiber, Rainer, Kunzelmann, Karl, Wetzel, Christian H., Weber, Bernhard H. F.

“…In response to cell swelling, volume-regulated anion channels (VRACs) participate in a process known as regulatory volume decrease (RVD). Only recently, first…”
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Kidney Volume and Functional Outcomes in Autosomal Dominant Polycystic Kidney Disease by Chapman, Arlene B, Bost, James E, Torres, Vicente E, Guay-Woodford, Lisa, Bae, Kyongtae Ty, Landsittel, Douglas, Li, Jie, King, Bernard F, Martin, Diego, Wetzel, Louis H, Lockhart, Mark E, Harris, Peter C, Moxey-Mims, Marva, Flessner, Mike, Bennett, William M, Grantham, Jared J

“…Autosomal dominant polycystic kidney disease (ADPKD) is characterized by increased total kidney volume (TKV) and renal failure. This study aimed to determine…”
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Structure-function relationships of the disease-linked A218T oxytocin receptor variant by Meyer, Magdalena, Jurek, Benjamin, Alfonso-Prieto, Mercedes, Ribeiro, Rui, Milenkovic, Vladimir M., Winter, Julia, Hoffmann, Petra, Wetzel, Christian H., Giorgetti, Alejandro, Carloni, Paolo, Neumann, Inga D.

“…Various single nucleotide polymorphisms (SNPs) in the oxytocin receptor (OXTR) gene have been associated with behavioral traits, autism spectrum disorder (ASD)…”
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CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells by Milenkovic, Vladimir M, Slim, Dounia, Bader, Stefanie, Koch, Victoria, Heinl, Elena-Sofia, Alvarez-Carbonell, David, Nothdurfter, Caroline, Rupprecht, Rainer, Wetzel, Christian H

“…The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. It has been…”
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Transient Receptor Potential Channel A1 Is Directly Gated by Calcium Ions by Doerner, Julia F., Gisselmann, Günter, Hatt, Hanns, Wetzel, Christian H.

“…Members of the superfamily of transient receptor potential (TRP) channels are proposed to play important roles in sensory physiology. As an excitatory ion…”
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Prediction of Functional Consequences of Missense Mutations in ANO4 Gene by Reichhart, Nadine, Milenkovic, Vladimir M, Wetzel, Christian H, Strauß, Olaf

“…The anoctamin (TMEM16) family of transmembrane protein consists of ten members in vertebrates, which act as Ca -dependent ion channels and/or Ca -dependent…”
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Myocyte Enhancer Factor 2A (MEF2A) Defines Oxytocin-Induced Morphological Effects and Regulates Mitochondrial Function in Neurons by Meyer, Magdalena, Kuffner, Kerstin, Winter, Julia, Neumann, Inga D, Wetzel, Christian H, Jurek, Benjamin

“…The neuropeptide oxytocin (OT) is a well-described modulator of socio-emotional traits, such as anxiety, stress, social behavior, and pair bonding. However,…”
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The Role of Translocator Protein TSPO in Hallmarks of Glioblastoma by Ammer, Laura-Marie, Vollmann-Zwerenz, Arabel, Ruf, Viktoria, Wetzel, Christian H., Riemenschneider, Markus J., Albert, Nathalie L., Beckhove, Philipp, Hau, Peter

“…Glioblastoma (GBM) is the most fatal primary brain cancer in adults. Despite extensive treatment, tumors inevitably recur, leading to an average survival time…”
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De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein by Germelli, Lorenzo, Da Pozzo, Eleonora, Giacomelli, Chiara, Tremolanti, Chiara, Marchetti, Laura, Wetzel, Christian H, Barresi, Elisabetta, Taliani, Sabrina, Da Settimo, Federico, Martini, Claudia, Costa, Barbara

“…Neuroactive steroids are potent modulators of microglial functions and are capable of counteracting their excessive reactivity. This action has mainly been…”
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Mitochondrial and Cellular Function in Fibroblasts, Induced Neurons, and Astrocytes Derived from Case Study Patients: Insights into Major Depression as a Mitochondria-Associated Disease by Cardon, Iseline, Grobecker, Sonja, Kücükoktay, Selin, Bader, Stefanie, Jahner, Tatjana, Nothdurfter, Caroline, Koschitzki, Kevin, Berneburg, Mark, Weber, Bernhard H F, Stöhr, Heidi, Höring, Marcus, Liebisch, Gerhard, Braun, Frank, Rothammer-Hampl, Tanja, Riemenschneider, Markus J, Rupprecht, Rainer, Milenkovic, Vladimir M, Wetzel, Christian H

“…The link between mitochondria and major depressive disorder (MDD) is increasingly evident, underscored both by mitochondria's involvement in many mechanisms…”
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Astringency Is a Trigeminal Sensation That Involves the Activation of G Protein-Coupled Signaling by Phenolic Compounds by SCHOBEL, Nicole, RADTKE, Debbie, WETZEL, Christian H, VOGT-EISELE, Angela, GISSELMANN, Günter, LEY, Jakob P, BARTOSHUK, Linda M, SPEHR, Jennifer, HOFMANN, Thomas, HATT, Hanns, KYEREME, Jessica, WOLLMANN, Nadine, CICHY, Annika, OBST, Katja, KALLWEIT, Kerstin, KLETKE, Olaf, MINOVI, Amir, DAZERT, Stefan

“…Astringency is an everyday sensory experience best described as a dry mouthfeel typically elicited by phenol-rich alimentary products like tea and wine. The…”
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Identification of a Testicular Odorant Receptor Mediating Human Sperm Chemotaxis by Spehr, Marc, Gisselmann, Günter, Poplawski, Alexandra, Riffell, Jeffrey A., Wetzel, Christian H., Zimmer, Richard K., Hatt, Hanns

“…Although it has been known for some time that olfactory receptors (ORs) reside in spermatozoa, the function of these ORs is unknown. Here, we identified,…”
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Effects of genetic variants in the TSPO gene on protein structure and stability by Milenkovic, Vladimir M, Bader, Stefanie, Sudria-Lopez, Daniel, Siebert, Ramona, Brandl, Caroline, Nothdurfter, Caroline, Weber, Bernhard H F, Rupprecht, Rainer, Wetzel, Christian H

“…The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. Expression of…”
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