Search Results - "Wetzel, Dawn M."

CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT by Mohamed, Mohamed F., Gupta, Kajal, Goldufsky, Josef W., Roy, Ruchi, Callaghan, Lauren T., Wetzel, Dawn M., Kuzel, Timothy M., Reiser, Jochen, Shafikhani, Sasha H.

“…Type 3 Secretion System (T3SS) is a highly conserved virulence structure that plays an essential role in the pathogenesis of many Gram-negative pathogenic…”
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The Abl and Arg Kinases Mediate Distinct Modes of Phagocytosis and Are Required for Maximal Leishmania Infection by Wetzel, Dawn M., McMahon-Pratt, Diane, Koleske, Anthony J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cutaneous Leishmania mexicana infections in the United States: defining strains through endemic human pediatric cases in northern Texas by Nepal, Binita, McCormick-Baw, Clare, Patel, Karisma, Firmani, Sarah, Wetzel, Dawn M

“…Over a 6-month span, three patients under 5 years old with cutaneous leishmaniasis presented to the Pediatric Infectious Diseases Clinic at the University of…”
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MAPK/ERK activation in macrophages promotes Leishmania internalization and pathogenesis by Barrie, Umaru, Floyd, Katherine, Datta, Arani, Wetzel, Dawn M.

“…The obligate intracellular parasite Leishmania binds several receptors to trigger uptake by phagocytic cells, ultimately resulting in visceral or cutaneous…”
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Gliding Motility Leads to Active Cellular Invasion by Cryptosporidium parvum Sporozoites by Wetzel, Dawn M, Schmidt, Joann, Kuhlenschmidt, Mark S, Dubey, J.P, Sibley, L. David

“…We examined gliding motility and cell invasion by an early-branching apicomplexan, Cryptosporidium parvum, which causes diarrheal disease in humans and…”
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Calcium-mediated protein secretion potentiates motility in Toxoplasma gondii by Wetzel, Dawn M, Chen, Lea Ann, Ruiz, Felix A, Moreno, Silvia N J, Sibley, L David

“…Apicomplexans such as Toxoplasma gondii actively invade host cells using a unique parasite-dependent mechanism termed gliding motility. Calcium-mediated…”
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Toxoplasma replication is inhibited by MMV676477 without development of resistance by Abbaali, Izra, Truong, Danny, Wetzel, Dawn M, Morrissette, Naomi S

“…Protozoan parasites cause life-threatening infections in both humans and animals, including agriculturally significant livestock. Available treatments are…”
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Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii by Chini, Eduardo N, Nagamune, Kisaburo, Wetzel, Dawn M, Sibley, L David

“…The protozoan parasite Toxoplasma gondii relies on calcium-mediated exocytosis to secrete adhesins on to its surface where they can engage host cell receptors…”
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Using machine learning to dissect host kinases required for Leishmania internalization and development by Wei, Ling, Barrie, Umaru, Aloisio, Gina M., Khuong, Francis T.H., Arang, Nadia, Datta, Arani, Kaushansky, Alexis, Wetzel, Dawn M.

“…The Leishmania life cycle alternates between promastigotes, found in the sandfly, and amastigotes, found in mammals. When an infected sandfly bites a host,…”
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The relative rate of kill of the MMV Malaria Box compounds provides links to the mode of antimalarial action and highlights scaffolds of medicinal chemistry interest by Ullah, Imran, Sharma, Raman, Mete, Antonio, Biagini, Giancarlo A, Wetzel, Dawn M, Horrocks, Paul D

“…Abstract Objectives Rapid rate-of-kill (RoK) is a key parameter in the target candidate profile 1 (TCP1) for the next-generation antimalarial drugs for…”
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Potency and Preclinical Evidence of Synergy of Oral Azole Drugs and Miltefosine in an Ex Vivo Model of Leishmania ( Viannia ) panamensis Infection by Fernández, Olga Lucía, Rosales-Chilama, Mariana, Quintero, Natali, Travi, Bruno L, Wetzel, Dawn M, Gómez, María Adelaida, Saravia, Nancy Gore

“…Failure of treatment of cutaneous leishmaniasis with antimonial drugs and miltefosine is frequent. Use of oral combination therapy represents an attractive…”
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Src- and Abl-family kinases activate spleen tyrosine kinase to maximize phagocytosis and Leishmania infection by Ullah, Imran, Barrie, Umaru, Kernen, Rebecca M, Mamula, Emily T, Khuong, Francis Tho Huu, Booshehri, Laela M, Rhodes, Emma L, Bradford, James M, Datta, Arani, Wetzel, Dawn M

“…Leishmania spp. are obligate intracellular parasites that must be internalized by phagocytic cells to evade immune responses and cause disease. The uptake of…”
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The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection by Wetzel, Dawn M, Rhodes, Emma L, Li, Shaoguang, McMahon-Pratt, Diane, Koleske, Anthony J

“…Leishmaniasis is a devastating disease that disfigures or kills nearly two million people each year. Establishment and persistence of infection by the obligate…”
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Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity by Zhang, Zhen, Ray, Sneha, Imlay, Leah, Callaghan, Lauren T, Niederstrasser, Hanspeter, Mallipeddi, Prema Latha, Posner, Bruce A, Wetzel, Dawn M, Phillips, Margaret A, Smith, Myles W

“…The spiroindimicins are a unique class of chlorinated indole alkaloids characterized by three heteroaromatic rings structured around a congested spirocyclic…”
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A Multi-Color Immunofluorescence Assay to Distinguish Intracellular From External Leishmania Parasites by Datta, Arani, Barrie, Umaru, Wetzel, Dawn M

“…Leishmaniasis, a neglected tropical disease, is caused by the intracellular protozoan parasite . Upon its transmission through a sandfly bite, binds and enters…”
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Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A by Martin, Francis J, Gomez, Marisa I, Wetzel, Dawn M, Memmi, Guido, O'Seaghdha, Maghnus, Soong, Grace, Schindler, Christian, Prince, Alice

“…The activation of type I IFN signaling is a major component of host defense against viral infection, but it is not typically associated with immune responses…”
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An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization by Ullah, Imran, Gahalawat, Suraksha, Booshehri, Laela M, Niederstrasser, Hanspeter, Majumdar, Shreoshi, Leija, Christopher, Bradford, James M, Hu, Bin, Ready, Joseph M, Wetzel, Dawn M

“…The few frontline antileishmanial drugs are poorly effective and toxic. To search for new drugs for this neglected tropical disease, we tested the activity of…”
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An Outbreak of Brucellosis: An Adult and Pediatric Case Series by Hassouneh, Linda, Quadri, Syeda, Pichilingue-Reto, Patricia, Chaisavaneeyakorn, Sujittra, Cutrell, James B, Wetzel, Dawn M, Nijhawan, Ank E

“…Brucellosis is recognized as a neglected zoonotic disease and a major public health threat. The purpose of this study was to characterize epidemiological risk…”
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Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170 by Valetti, C, Wetzel, D M, Schrader, M, Hasbani, M J, Gill, S R, Kreis, T E, Schroer, T A

“…The flow of material from peripheral, early endosomes to late endosomes requires microtubules and is thought to be facilitated by the minus end-directed motor…”
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The Src kinases Hck, Fgr, and Lyn activate Abl2/Arg to facilitate IgG-mediated phagocytosis and Leishmania infection by Wetzel, Dawn M., Rhodes, Emma L., Li, Shaoguang, McMahon-Pratt, Diane, Koleske, Anthony J.

“…Leishmaniasis is a devastating disease that disfigures or kills nearly 2 million people each year. Establishment and persistence of infection by the obligate…”
Get full text