Search Results - "Wettstein, JG"

TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity by Revel, Florent G, Moreau, Jean-Luc, Gainetdinov, Raul R, Bradaia, Amyaouch, Sotnikova, Tatyana D, Mory, Roland, Durkin, Sean, Zbinden, Katrin Groebke, Norcross, Roger, Meyer, Claas A, Metzler, Veit, Chaboz, Sylvie, Ozmen, Laurence, Trube, Gerhard, Pouzet, Bruno, Bettler, Bernhard, Caron, Marc G, Wettstein, Joseph G, Hoener, Marius C

“…The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and β-phenylethylamine, has…”
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Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression by Lindemann, Lothar, Porter, Richard H, Scharf, Sebastian H, Kuennecke, Basil, Bruns, Andreas, von Kienlin, Markus, Harrison, Anthony C, Paehler, Axel, Funk, Christoph, Gloge, Andreas, Schneider, Manfred, Parrott, Neil J, Polonchuk, Liudmila, Niederhauser, Urs, Morairty, Stephen R, Kilduff, Thomas S, Vieira, Eric, Kolczewski, Sabine, Wichmann, Juergen, Hartung, Thomas, Honer, Michael, Borroni, Edilio, Moreau, Jean-Luc, Prinssen, Eric, Spooren, Will, Wettstein, Joseph G, Jaeschke, Georg

“…Major depressive disorder (MDD) is a serious public health burden and a leading cause of disability. Its pharmacotherapy is currently limited to modulators of…”
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CCK antagonists: pharmacology and therapeutic interest by Wettstein, J G, Buéno, L, Junien, J L

“…CCK was first identified and characterized in the digestive tract where it is known to be a factor involved in the control of gut motility. Later, CCK and CCK…”
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Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators by Lundström, L, Bissantz, C, Beck, J, Wettstein, JG, Woltering, TJ, Wichmann, J, Gatti, S

“…BACKGROUND AND PURPOSE Altered glutamatergic neurotransmission is linked to several neurological and psychiatric disorders. Metabotropic glutamate receptor 2…”
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Biochemical and behavioural characterization of EMPA, a novel high‐affinity, selective antagonist for the OX 2 receptor by Malherbe, P, Borroni, E, Gobbi, L, Knust, H, Nettekoven, M, Pinard, E, Roche, O, Rogers‐Evans, M, Wettstein, JG, Moreau, J‐L

“…Background and purpose:  The OX 2 receptor is a G‐protein‐coupled receptor that is abundantly found in the tuberomammillary nucleus, an important site for the…”
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Biochemical and behavioural characterization of EMPA, a novel high‐affinity, selective antagonist for the OX2 receptor by Malherbe, P, Borroni, E, Gobbi, L, Knust, H, Nettekoven, M, Pinard, E, Roche, O, Rogers‐Evans, M, Wettstein, JG, Moreau, J‐L

“…Background and purpose:  The OX2 receptor is a G‐protein‐coupled receptor that is abundantly found in the tuberomammillary nucleus, an important site for the…”
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Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK1 and NK3 receptors by Malherbe, P, Knoflach, F, Hernandez, MC, Hoffmann, T, Schnider, P, Porter, RH, Wettstein, JG, Ballard, TM, Spooren, W, Steward, L

“…BACKGROUND AND PURPOSE Clinical results of osanetant and talnetant (selective‐NK3 antagonists) indicate that blocking the NK3 receptor could be beneficial for…”
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Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK 1 and NK 3 receptors by Malherbe, P, Knoflach, F, Hernandez, MC, Hoffmann, T, Schnider, P, Porter, RH, Wettstein, JG, Ballard, TM, Spooren, W, Steward, L

“…BACKGROUND AND PURPOSE Clinical results of osanetant and talnetant (selective‐NK 3 antagonists) indicate that blocking the NK 3 receptor could be beneficial…”
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Central nervous system pharmacology of neuropeptide Y by Wettstein, J.G, Earley, B, Junien, J.L

“…Neuropeptide Y (NPY) is a 36-amino acid peptide belonging to the pancreatic polypeptide family that has marked and diverse biological activity across species…”
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On the effect of neonatal nitric oxide synthase inhibition in rats: a potential neurodevelopmental model of schizophrenia by Black, Mark D., Selk, David E., Hitchcock, J.M., Wettstein, Joseph G., Sorensen, Stephen M.

“…NADPH-d (nicotinamide-adenine dinucleotide phosphate-diaphorase) neurons are thought to migrate improperly during development in the brains of schizophrenic…”
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Delayed treatment with 5-nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione, a glycine site N-methyl- d-aspartate antagonist, protects against permanent middle cerebral artery occlusion in male rats by Sarhan, Shakir, Wettstein, Joseph G., Maynard, Kenneth I.

“…The glycine site, N-methyl- d-aspartate antagonist 5-nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione (ACEA1021) was previously tested only in models of…”
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Elements of cerebral microvascular ischaemia by Petty, M.A, Wettstein, J.G

“…Although neuronal cells have long been thought to be the prime target of ischaemic insults, events which occur at the blood–vascular–parenchymal interface are…”
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Neonatal nitric oxide synthase inhibition: social interaction deficits in adulthood and reversal by antipsychotic drugs by Black, M.D., Simmonds, J., Senyah, Y., Wettstein, J.G.

“…Nitric oxide synthase (NOS) is thought to migrate improperly during development in the brains of schizophrenic patients. Also it is known that nitric oxide…”
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In vivo neuroprotective effects of ACEA 1021 confirmed by magnetic resonance imaging in ischemic stroke by Petty, Margaret A, Neumann-Haefelin, Claudia, Kalisch, Juergen, Sarhan, Shakir, Wettstein, Joseph G, Juretschke, Hans-Paul

“…The neuroprotective activity of ACEA 1021 (5-nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione; licostinel), a selective antagonist at the…”
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Comparative analysis of acute and chronic administration of haloperidol and clozapine using [ 3H] 2-deoxyglucose metabolic mapping by Wotanis, Jill, Hanak, Susan E., Wettstein, Joseph G., Black, Mark D.

“…In an effort to compare and contrast the mechanisms of action of typical and atypical antipsychotic drugs, [ 3H] 2-deoxyglucose metabolic mapping was employed…”
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Selectivity of action of typical and atypical antipsychotic drugs as antagonists of the behavioral effects of 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) by Wettstein, Joseph G., Host, Martine, Hitchcock, Janice M.

“…1. 1. There has been considerable research in the field of schizophrenia over the past few years with emphasis on the discovery of better drugs, particularly…”
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The acoustic startle reflex in Sprague-Dawley rats is altered by permanent middle cerebral artery occlusion by Maynard, Kenneth I., Sukoff, Stacey J., Ji, Zhongqi, Wettstein, Joseph G., Black, Mark D.

“…The startle reflex is an unconditioned, quantifiable behavior used to study sensory modalities. We examined whether the acoustic startle reflex (ASR) was…”
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An electrophysiological model of spinal transmission deficits in mouse experimental autoimmune encephalomyelitis by Hanak, Susan E, Reilly, Erin M, Wotanis, Jill, Zhu, Bin, Pulicicchio, Claudine, McMonagle-Strucko, Kathleen, Wettstein, Joseph G, Black, Mark D

“…Chronic relapsing/remitting experimental autoimmune encephalomyelitis (EAE) can be induced in 8-week-old female SJL/J(H-2) mice via inoculation with the…”
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Disruption of latent inhibition in the rat by the 5-HT2 agonist DOI: effects of MDL 100,907, clozapine, risperidone and haloperidol by HITCHCOCK, J. M, LISTER, S, FISCHER, T. R, WETTSTEIN, J. G

“…Latent inhibition (LI), a measure of the ability to learn to ignore irrelevant stimuli, is disrupted in acute schizophrenics and in rats treated with…”
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Comparative Antipsychotic Profiles of Neurotensin and a Related Systemically Active Peptide Agonist by Sarhan, Shakir, Hitchcock, Janice M, Grauffel, Christine A, Wettstein, Joseph G

“…Sarhan, S., J. M. Hitchcock, C. A. Grauffel and J. G. Wettstein. Comparative antipsychotic profiles of neurotensin and a related systemically active peptide…”
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