Search Results - "Wettig, Shawn"

Modified gelatin nanoparticles for gene delivery by Madkhali, Osama, Mekhail, George, Wettig, Shawn D.

“…[Display omitted] Gelatin nanoparticles (GNPs) are one of the most extensively used natural polymers for gene therapy. With advantages of being biodegradable,…”
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Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery by Callender, Shannon P., Mathews, Jessica A., Kobernyk, Katherine, Wettig, Shawn D.

“…[Display omitted] Emulsion technology has been utilized extensively in the pharmaceutical industry. This article presents a comprehensive review of the…”
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An Overview of Nanotechnologies for Drug Delivery to the Brain by Ayub, Ahsan, Wettig, Shawn

“…Drug delivery to the brain has been one of the toughest challenges researchers have faced to develop effective treatments for brain diseases. Owing to the…”
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Interactions between DNA and Gemini surfactant: impact on gene therapy: part I by Ahmed, Taksim, Kamel, Amany O, Wettig, Shawn D

“…Nonviral gene therapy using gemini surfactants is a unique approach to medicine that can be adapted toward the treatment of various diseases. Recently, gemini…”
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Continuous Langmuir–Blodgett Deposition and Transfer by Controlled Edge-to-Edge Assembly of Floating 2D Materials by Xu, Luzhu, Tetreault, Adam R, Khaligh, Hadi H, Goldthorpe, Irene A, Wettig, Shawn D, Pope, Michael A

“…The Langmuir–Blodgett technique is one of the most controlled methods to deposit monomolecular layers of floating or surface active materials but has lacked…”
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Investigating the Phospholipid Effect on the Bioaccessibility of Rosmarinic Acid-Phospholipid Complex through a Dynamic Gastrointestinal in Vitro Model by Huang, Jiahao, Chen, Peter X, Rogers, Michael A, Wettig, Shawn D

“…Phyto-phospholipid complexes have been developed as a common way of improving the oral bioavailability of poorly absorbable phyto-pharmaceuticals; however, the…”
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Gemini surfactants: a new family of building blocks for non-viral gene delivery systems by Wettig, Shawn D, Verrall, Ronald E, Foldvari, Marianna

“…Gemini surfactants provide a significant opportunity in the development of new non-viral delivery systems designed for gene therapy applications. This review…”
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Challenges of Dissolution Methods Development for Soft Gelatin Capsules by Damian, Festo, Harati, Mohammad, Schwartzenhauer, Jeff, Van Cauwenberghe, Owen, Wettig, Shawn D

“…Recently, the development of soft gelatin capsules (SGCs) dosage forms has attracted a great deal of interest in the oral delivery of poorly water-soluble…”
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Cationic Gemini Surfactant–Plasmid Deoxyribonucleic Acid Condensates as a Single Amphiphilic Entity by Shortall, Samantha M, Wettig, Shawn D

“…A critical aggregate concentration for the surfactant–DNA “complex” or “condensate” consisting of the 16-3-16 gemini surfactant and circular plasmid DNA was…”
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Effect of Chemical Permeation Enhancers on Stratum Corneum Barrier Lipid Organizational Structure and Interferon Alpha Permeability by Moghadam, Shadi H, Saliaj, Evi, Wettig, Shawn D, Dong, Chilbert, Ivanova, Marina V, Huzil, J. Torin, Foldvari, Marianna

“…The outermost layer of the skin, known as the stratum corneum (SC), is composed of dead corneocytes embedded in an intercellular lipid matrix consisting of…”
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m-s-m cationic gemini and zwitterionic surfactants - a thermodynamic analysis of their mixed micelle formation by McLachlan, Aleisha, Singh, Kulbir, McAlduff, Michael, Marangoni, D Gerrard, Shortall, Samantha, Wettig, Shawn D

“…Micelle formation enthalpies (Δ values) have been calorimetrically determined at 298 K for three sets of mixed zwitterionic/cationic gemini systems consisting…”
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Synthesis and aggregation properties of dissymmetric phytanyl-gemini surfactants for use as improved DNA transfection vectors by Wang, Haitang, Wettig, Shawn D

“…Improvements in transfection efficiency are required in order to make the goal of cellular gene delivery by non-viral vectors realizable. Novel derivatives of…”
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Interactions between DNA and gemini surfactant: impact on gene therapy: part II by Ahmed, Taksim, Kamel, Amany O, Wettig, Shawn D

“…Nonviral gene delivery, provides distinct treatment modalities for the inherited and acquired diseases, relies upon the encapsulation of a gene of interest,…”
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Avocado-derived polyols for use as novel co-surfactants in low energy self-emulsifying microemulsions by Ahmed, Nawaz, Kermanshahi, Behnoush, Ghazani, Saeed M., Tait, Katrina, Tcheng, Matthew, Roma, Alessia, Callender, Shannon P., Smith, Richard W., Tam, William, Wettig, Shawn D., Rogers, Michael A., Marangoni, Alejandro G., Spagnuolo, Paul A.

“…Avocado ( Persea americana Mill.; Lauraceae) seed-derived polyhydroxylated fatty alcohols (PFAs) or polyols (i.e., avocadene and avocadyne) are metabolic…”
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Characterization of the Behavior of a Pyrene Substituted Gemini Surfactant in Water by Fluorescence by Keyes-Baig, Christine, Duhamel, Jean, Wettig, Shawn

“…Time-resolved fluorescence was applied to characterize the behavior in solution of a gemini surfactant substituted with pyrene (Py-3-12). Upon association in…”
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Physical Characterization of Gemini Surfactant-Based Synthetic Vectors for the Delivery of Linear Covalently Closed (LCC) DNA Ministrings by Sum, Chi Hong, Nafissi, Nafiseh, Slavcev, Roderick A, Wettig, Shawn

“…In combination with novel linear covalently closed (LCC) DNA minivectors, referred to as DNA ministrings, a gemini surfactant-based synthetic vector for gene…”
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Biodistribution and Physiologically-Based Pharmacokinetic Modeling of Gold Nanoparticles in Mice with Interspecies Extrapolation by Aborig, Mohamed, Malik, Paul R V, Nambiar, Shruti, Chelle, Pierre, Darko, Johnson, Mutsaers, Anthony, Edginton, Andrea N, Fleck, Andre, Osei, Ernest, Wettig, Shawn

“…Gold nanoparticles (AuNPs) are a focus of growing medical research applications due to their unique chemical, electrical and optical properties. Because of…”
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Nanoscale Structure of Lipid-Gemini Surfactant Mixed Monolayers Resolved with AFM and KPFM Microscopy by Henderson, Robert D E, Mei, Nanqin, Xu, Yue, Gaikwad, Ravi, Wettig, Shawn, Leonenko, Zoya

“…Drug delivery vehicles composed of lipids and gemini surfactants (GS) are promising in gene therapy. Tuning the composition and properties of the delivery…”
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Mixed aggregate formation in gemini surfactant/1,2-dialkyl-sn-glycero-3-phosphoethanolamine systems by Akbar, Javed, Tavakoli, Naser, Gerrard Marangoni, D., Wettig, Shawn D.

“…[Display omitted] ► Gemini surfactant/DNA/lipid systems have been studied by surface tension. ► DNA/gemini surfactant interactions depend strongly on…”
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Synthesis and evaluation of alendronate-modified gelatin biopolymer as a novel osteotropic nanocarrier for gene therapy by Mekhail, George M, Kamel, Amany O, Awad, Gehanne AS, Mortada, Nahed D, Rodrigo, Rowena L, Spagnuolo, Paul A, Wettig, Shawn D

“…To synthesize an osteotropic alendronate functionalized gelatin (ALN-gelatin) biopolymer for nanoparticle preparation and targeted delivery of DNA to…”
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