Search Results - "Wetterhahn, Karen E"

Direct and Hydrogen Peroxide-Induced Chromium(V) Oxidation of Deoxyribose in Single-Stranded and Double-Stranded Calf Thymus DNA by Sugden, Kent D, Wetterhahn, Karen E

“…Oxidative DNA damage by a model Cr(V) complex, [CrO(ehba)2]-, with and without added H2O2, was investigated for the formation of base and sugar products…”
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Reduction of Chromium(VI) by Ascorbate Leads to Chromium-DNA Binding and DNA Strand Breaks in Vitro by Stearns, Diane M, Kennedy, Laura J, Courtney, Kevin D, Giangrande, Paloma H, Phieffer, Laura S, Wetterhahn, Karen E

“…Chromium(VI) is a known human carcinogen which requires intracellular reduction for activation. Ascorbate (vitamin C) has been reported to function as a major…”
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Reaction of Chromium(VI) with Ascorbate Produces Chromium(V), Chromium(IV), and Carbon-Based Radicals by Stearns, Diane M, Wetterhahn, Karen E

“…Reaction of potassium dichromate with sodium ascorbate was studied by EPR spectroscopy at room temperature, in 0.10 M…”
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Identification of the Oxidized Products Formed upon Reaction of Chromium(V) with Thymidine Nucleotides by Sugden, Kent D, Wetterhahn, Karen E

“…Two pathways have been observed for Cr(V)-mediated nucleotide oxidation in reactions of bis(2-ethyl-2-hydroxybutyrato)oxochromate(V) [CrO(ehba)2]- with…”
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Effects of Cr(VI) on the expression of the oxidative stress genes in human lung cells by DUBROVSKAYA, V. A, WETTERHAHN, K. E

“…Intracellular metabolism of chromium(VI) [Cr(VI)] may lead to oxidative stress and this may account for the ability of Cr(VI) to act as a complete carcinogen…”
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Chromium(VI) forms a thiolate complex with glutathione by Brauer, Samuel L, Wetterhahn, Karen E

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EPR Evidence for Chromium(V) Binding to Phosphate and Pyrophosphate:  Implications for Chromium(V)−DNA Interactions by Sugden, Kent D, Wetterhahn, Karen E

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Reaction of Chromium(V) with the EPR Spin Traps 5,5-Dimethylpyrroline N-Oxide and Phenyl-N-tert-butylnitrone Resulting in Direct Oxidation by Sugden, Kent D, Wetterhahn, Karen E

“…Experiments were performed to investigate potential biologically relevant oxidation reactions of a model Cr(V) complex, sodium…”
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Chromium(VI) Forms Thiolate Complexes with γ-Glutamylcysteine, N-Acetylcysteine, Cysteine, and the Methyl Ester of N-Acetylcysteine by Brauer, Samuel L, Hneihen, Azzam S, McBride, John S, Wetterhahn, Karen E

“…Reaction of potassium dichromate with γ-glutamylcysteine, N-acetylcysteine, and cysteine in aqueous solution resulted in the formation of 1:1 complexes of…”
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Is there a role for reactive oxygen species in the mechanism of chromium(VI) carcinogenesis? by Standeven, Andrew M, Wetterhahn, Karen E

“…The purpose of this article is to critically review the evidence that reactive oxygen species are involved in the carcinogenic mechanism of Cr(VI). Since it is…”
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Reaction of Chromium(VI) with Glutathione or with Hydrogen Peroxide: Identification of Reactive Intermediates and Their Role in Chromium(VI)-Induced DNA Damage by Aiyar, Jayshree, Berkovits, Holly J., Floyd, Robert A., Wetterhahn, Karen E.

“…The types of reactive intermediates generated upon reduction of chromium(VI) by glutathione or hydrogen peroxide and the resulting DNA damage have been…”
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Intermediates Produced in the Reaction of Chromium(VI) with Dehydroascorbate Cause Single-Strand Breaks in Plasmid DNA by Stearns, Diane M, Wetterhahn, Karen E

“…Ascorbate (vitamin C) is a biological reductant of the human carcinogen chromium(VI). The product of this reaction is presumed to be dehydroascorbate. However,…”
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Molecular basis of hexavalent chromium carcinogenicity: effect on gene expression by Wetterhahn, K E, Hamilton, J W

“…The carcinogenicity of chromium(VI) compounds is explained in terms of the "uptake-reduction" model. According to this model, chromium (VI) enters cells as the…”
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Reaction of chromium(VI) with hydrogen peroxide in the presence of glutathione: reactive intermediates and resulting DNA damage by Aiyar, Jayshree, Berkovits, Holly J, Floyd, Robert A, Wetterhahn, Karen E

“…The reaction of chromium(VI) with hydrogen peroxide was studied in the presence of glutathione. In vitro, reaction of chromium(VI) with hydrogen peroxide alone…”
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Methyl Transfer to Mercury Thiolates:  Effects of Coordination Number and Ligand Dissociation by Wilker, Jonathan J., Wetterhahn, Karen E., Lippard, Stephen J.

“…The complexes [(CH3)4N]2[Hg(SC6H5)4] and [(C4H9)4N][Hg(SC6H5)3] demethylate (CH3O)3PO as revealed by 1H, 31P{1H}, and 199Hg{1H} NMR spectroscopy in DMSO-d 6…”
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Chromium cross-links glutathione and cysteine to DNA by Borges, K M, Wetterhahn, K E

“…The formation of chromium-DNA adducts, and chromium-mediated peptide-DNA or amino acid-DNA cross-links was measured after treatment of calf thymus DNA and…”
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Differential binding of chromium(VI) and chromium(III) complexes to salmon sperm nuclei and nuclear DNA and isolated calf thymus DNA by Hneihen, A S, Standeven, A M, Wetterhahn, K E

“…The binding of CrCl3.6H2O, Cr(NO3)3.9H2O, [Cr(L-His)2] (NO3)3.H2O, [Cr(L-Cys)(L-His)].3.5H2O, [Cr(L-His)(D-Pen)].H2O, Na[Cr(L-Cys)2].2H2O, K2[Cr(GS)2].3H2O,…”
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Binding of chromium to chromatin and DNA from liver and kidney of rats treated with sodium dichromate and chromium(III) chloride in vivo by CUPO, D. Y, WETTERHAHN, K. E

“…The in vivo binding of chromium to whole chromatin, polynucleosomes, DNA, and cytoplasmic RNA-protein fraction from liver and kidney was examined after…”
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In vivo formation of chromium(V) in chick embryo red blood cells by Liebross, Robert H, Wetterhahn, Karen E

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Mitochondrial reduction of the carcinogen chromate: formation of chromium(V) by Rossi, Susan C, Gorman, Nadia, Wetterhahn, Karen E

“…Incubation of chromate with isolated rat liver mitochondria in vitro resulted in the uptake and reduction of chromium(VI), as well as the formation of…”
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