Search Results - "Wetsel, Rick A"

Targeted Disruption of the β2‐Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells by Wang, Dachun, Quan, Yuan, Yan, Qing, Morales, John E., Wetsel, Rick A.

“…It was hypothesized that transplanting human embryonic stem cells (hESCs) lacking human leukocyte antigen class I (HLA‐I) expression would not result in a…”
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Circadian Clock and Complement Immune System-Complementary Control of Physiology and Pathology? by Shivshankar, Pooja, Fekry, Baharan, Eckel-Mahan, Kristin, Wetsel, Rick A

“…Mammalian species contain an internal circadian (i.e., 24-h) clock that is synchronized to the day and night cycles. Large epidemiological studies, which are…”
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receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization by Wu, Mike C. L., Brennan, Faith H., Lynch, Jason P. L., Mantovani, Susanna, Phipps, Simon, Wetsel, Rick A., Ruitenberg, Marc J., Taylor, Stephen M., Woodruff, Trent M.

“…C3a is a key complement activation fragment, yet its neutrophil-expressed receptor (C3aR) still has no clearly defined role. In this study, we used a…”
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Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo by Zhang, Xinhua, Kimura, Yuko, Fang, Chongyun, Zhou, Lin, Sfyroera, Georgia, Lambris, John D., Wetsel, Rick A., Miwa, Takashi, Song, Wen-Chao

“…Toll-like receptors (TLRs) and complement are 2 components of innate immunity that are critical for first-line host defense and elicitation of adaptive immune…”
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Transplantation of Human Embryonic Stem Cell–Derived Alveolar Epithelial Type II Cells Abrogates Acute Lung Injury in Mice by Wang, Dachun, Morales, John E, Calame, Daniel G, Alcorn, Joseph L, Wetsel, Rick A

“…Respiratory diseases are a major cause of mortality and morbidity worldwide. Current treatments offer no prospect of cure or disease reversal. Transplantation…”
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pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells by Wang, Dachun, Haviland, David L, Burns, Alan R, Zsigmond, Eva, Wetsel, Rick A

“…Alveolar epithelial type II (ATII) cells are small, cuboidal cells that constitute [almost equal to]60% of the pulmonary alveolar epithelium. These cells are…”
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Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells by Kim, Young Uk, Lim, Hoyong, Jung, Ha Eun, Wetsel, Rick A, Chung, Yeonseok

“…BXD2 mice spontaneously develop autoantibodies and subsequent glomerulonephritis, offering a useful animal model to study autoimmune lupus. Although initial…”
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Generation of C5a in the absence of C3: a new complement activation pathway by Ward, Peter A, Huber-Lang, Markus, Sarma, J Vidya, Zetoune, Firas S, Rittirsch, Daniel, Neff, Thomas A, McGuire, Stephanie R, Lambris, John D, Warner, Roscoe L, Flierl, Michael A, Hoesel, Laszlo M, Gebhard, Florian, Younger, John G, Drouin, Scott M, Wetsel, Rick A

“…Complement-mediated tissue injury in humans occurs upon deposition of immune complexes, such as in autoimmune diseases and acute respiratory distress syndrome…”
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Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss by Hernandez, Michael X, Jiang, Shan, Cole, Tracy A, Chu, Shu-Hui, Fonseca, Maria I, Fang, Melody J, Hohsfield, Lindsay A, Torres, Maria D, Green, Kim N, Wetsel, Rick A, Mortazavi, Ali, Tenner, Andrea J

“…Pharmacologic inhibition of C5aR1, a receptor for the complement activation proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in…”
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C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation by Bierschenk, Damien, Papac-Milicevic, Nikolina, Bresch, Ian P, Kovacic, Valentina, Bettoni, Serena, Dziedzic, Mateusz, Wetsel, Rick A, Eschenburg, Susanne, Binder, Christoph J, Blom, Anna M, King, Ben C

“…Dysregulated NLRP3 inflammasome activation drives a wide variety of diseases, while endogenous inhibition of this pathway is poorly characterised. The serum…”
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Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence by Wang, Yanyu, Jenkins, Sarah A, Gu, Chunfang, Shree, Ankita, Martinez-Moczygemba, Margarita, Herold, Jennifer, Botto, Marina, Wetsel, Rick A, Xu, Yi

“…Spores of Bacillus anthracis, the causative agent of anthrax, are known to persist in the host lungs for prolonged periods of time, however the underlying…”
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The C5a anaphylatoxin receptor (C5aR1) protects against Listeria monocytogenes infection by inhibiting type 1 IFN expression by Calame, Daniel G, Mueller-Ortiz, Stacey L, Morales, John E, Wetsel, Rick A

“…Listeria monocytogenes is a major cause of mortality resulting from food poisoning in the United States. In mice, C5 has been genetically linked to host…”
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Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections by Muenstermann, Marcel, Strobel, Lea, Klos, Andreas, Wetsel, Rick A., Woodruff, Trent M., Köhl, Jörg, Johswich, Kay O.

“…The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane…”
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Correction: Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence by Wang, Yanyu, Jenkins, Sarah A, Gu, Chunfang, Shree, Ankita, Martinez-Moczygemba, Margarita, Herold, Jennifer, Botto, Marina, Wetsel, Rick A, Xu, Yi

“…[This corrects the article DOI: 10.1371/journal.ppat.1005678.]…”
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The Regulation of Liver Cell Survival by Complement by Markiewski, Maciej M, DeAngelis, Robert A, Strey, Christoph W, Foukas, Periklis G, Gerard, Craig, Gerard, Norma, Wetsel, Rick A, Lambris, John D

“…Complement effectors are known to contribute to host cell injury in several inflammatory diseases. Contrary to this paradigm, in this study utilizing surgical…”
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The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice by Wende, Elisabeth, Laudeley, Robert, Bleich, André, Bleich, Eva, Wetsel, Rick A, Glage, Silke, Klos, Andreas

“…Inflammatory bowel diseases are a critical public health issue, and as treatment options remain limited, there is a need to unravel the underlying…”
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A Preclinical Safety Study of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells for Macular Degeneration by Mazzilli, John L, Snook, Joshua D, Simmons, Ken, Domozhirov, Aleksey Y, Garcia, Charles A, Wetsel, Rick A, Zsigmond, Eva M, Westenskow, Peter D

“…Age-related macular degeneration (AMD) is a common disease trending towards epidemic proportions and is a leading cause of irreversible vision loss in people…”
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Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndrome by Domozhirov, Aleksey Y., Mazzilli, John L., Wetsel, Rick A., Zsigmond, Eva M.

“…Monosomy of chromosome X is associated with high prenatal mortality of female embryos and severe developmental abnormalities of patients born with Turner's…”
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Negative regulation of pulmonary Th17 responses by C3a anaphylatoxin during allergic inflammation in mice by Lim, Hoyong, Kim, Young Uk, Drouin, Scott M, Mueller-Ortiz, Stacey, Yun, Kyoungah, Morschl, Eva, Wetsel, Rick A, Chung, Yeonseok

“…Activation of complement is one of the earliest immune responses to exogenous threats, resulting in various cleavage products including anaphylatoxin C3a. In…”
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Therapeutic potential of lung epithelial progenitor cells derived from embryonic and induced pluripotent stem cells by Wetsel, Rick A, Wang, Dachun, Calame, Daniel G

“…Embryonic stem (ES) cells derived from preimplantation blastocysts and induced pluripotent stem (iPS) cells generated from somatic cell sources are pluripotent…”
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