Search Results - "Wetsel, RA"

Generation of C5a in the absence of C3: a new complement activation pathway by Ward, Peter A, Huber-Lang, Markus, Sarma, J Vidya, Zetoune, Firas S, Rittirsch, Daniel, Neff, Thomas A, McGuire, Stephanie R, Lambris, John D, Warner, Roscoe L, Flierl, Michael A, Hoesel, Laszlo M, Gebhard, Florian, Younger, John G, Drouin, Scott M, Wetsel, Rick A

“…Complement-mediated tissue injury in humans occurs upon deposition of immune complexes, such as in autoimmune diseases and acute respiratory distress syndrome…”
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Complement: a novel factor in basal and ischemia-induced neurogenesis by Rahpeymai, Yalda, Hietala, Max Albert, Wilhelmsson, Ulrika, Fotheringham, Andrew, Davies, Ioan, Nilsson, Ann-Katrin, Zwirner, Jörg, Wetsel, Rick A, Gerard, Craig, Pekny, Milos, Pekna, Marcela

“…Through its involvement in inflammation, opsonization, and cytolysis, the complement protects against infectious agents. Although most of the complement…”
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Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow by Ratajczak, Janina, Reca, Ryan, Kucia, Magda, Majka, Marcin, Allendorf, Daniel J., Baran, Jarek T., Janowska-Wieczorek, Anna, Wetsel, Rick A., Ross, Gordon D., Ratajczak, Mariusz Z.

“…The mechanisms regulating the homing/mobilization of hematopoietic stem/progenitor cells (HSPCs) are not fully understood. In our previous studies we showed…”
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Deletion of the Complement Anaphylatoxin C3a Receptor Attenuates, Whereas Ectopic Expression of C3a in the Brain Exacerbates, Experimental Autoimmune Encephalomyelitis by Boos, Laura, Campbell, Iain L, Ames, Robert, Wetsel, Rick A, Barnum, Scott R

“…The C3aR is expressed throughout the CNS and is increased in expression on glial cells during CNS inflammation. However, the role that C3a and the C3aR play in…”
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C3a and C3b Activation Products of the Third Component of Complement (C3) Are Critical for Normal Liver Recovery after Toxic Injury by Markiewski, Maciej M, Mastellos, Dimitrios, Tudoran, Ruxandra, DeAngelis, Robert A, Strey, Christoph W, Franchini, Silvia, Wetsel, Rick A, Erdei, Anna, Lambris, John D

“…Although the complement system has been implicated in liver regeneration after toxic injury and partial hepatectomy, the mechanism or mechanisms through which…”
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Carboxypeptidase N: a pleiotropic regulator of inflammation by Matthews, Kirstin W, Mueller-Ortiz, Stacey L, Wetsel, Rick A

“…Carboxypeptidase N (CPN) is a plasma zinc metalloprotease, which consists of two enzymatically active small subunits (CPN1) and two large subunits (CPN2) that…”
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Absence of the Complement Anaphylatoxin C3a Receptor Suppresses Th2 Effector Functions in a Murine Model of Pulmonary Allergy by Drouin, Scott M, Corry, David B, Hollman, Travis J, Kildsgaard, Jens, Wetsel, Rick A

“…Asthma is a chronic inflammatory disease of the lung resulting in airway obstruction. The airway inflammation of asthma is strongly linked to Th2 lymphocytes…”
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Inhibition of Complement Activation by a Secreted Staphylococcus aureus Protein by Lee, Lawrence Y. L., Höök, Magnus, Haviland, David, Wetsel, Rick A., Yonter, Edward O., Syribeys, Peter, Vernachio, John, Brown, Eric L.

“…Staphylococcus aureus can cause a variety of acute and chronic diseases. The ability of S. aureus to cause persistent infections has been linked to its ability…”
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A Protective Role for the Fifth Complement Component (C5) in Allergic Airway Disease by Drouin, Scott M, Sinha, Meenal, Sfyroera, Georgia, Lambris, John D, Wetsel, Rick A

“…Reports from our laboratory, as well as those from others, have documented the importance of complement activation, the C3a anaphylatoxin, and its receptor,…”
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C5a receptor deficiency attenuates T cell function and renal disease in MRL1pr mice by WENDERFER, Scott E, KE, Baozhen, HOLLMANN, Travis J, WETSEL, Rick A, HUI YAO LAN, BRAUN, Michael C

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Cutting Edge: Targeted Disruption of the C3a Receptor Gene Demonstrates a Novel Protective Anti-Inflammatory Role for C3a in Endotoxin-Shock by Kildsgaard, Jens, Hollmann, Travis J, Matthews, Kirstin W, Bian, Ka, Murad, Ferid, Wetsel, Rick A

“…The complement anaphylatoxin C3a, on binding the C3aR, mediates numerous proinflammatory activities. In addition, recent in vitro studies with C3a have…”
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The Alternative Activation Pathway and Complement Component C3 Are Critical for a Protective Immune Response against Pseudomonas aeruginosa in a Murine Model of Pneumonia by MUELLER-ORTIZ, Stacey L, DROUIN, Scott M, WETSEL, Rick A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Expression of the Complement Anaphylatoxin C3a and C5a Receptors on Bronchial Epithelial and Smooth Muscle Cells in Models of Sepsis and Asthma by Drouin, Scott M, Kildsgaard, Jens, Haviland, Joie, Zabner, Joseph, Jia, Hong Pen, McCray, Paul B., Jr, Tack, Brian F, Wetsel, Rick A

“…The presence of the complement-derived anaphylatoxin peptides, C3a and C5a, in the lung can induce respiratory distress characterized by contraction of the…”
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Modulation of Renal Disease in MRL/lpr Mice Genetically Deficient in the Alternative Complement Pathway Factor B by Watanabe, Hiroshi, Garnier, Gerard, Circolo, Antonella, Wetsel, Rick A, Ruiz, Phil, Holers, V. Michael, Boackle, Susan A, Colten, Harvey R, Gilkeson, Gary S

“…In systemic lupus erythematosus, the renal deposition of complement-containing immune complexes initiates an inflammatory cascade resulting in…”
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Cutting Edge: The Absence of C3 Demonstrates a Role for Complement in Th2 Effector Functions in a Murine Model of Pulmonary Allergy by Drouin, Scott M, Corry, David B, Kildsgaard, Jens, Wetsel, Rick A

“…Asthma is a chronic disease of the lung resulting from airway obstruction. Although the initiating causes are not entirely clear, the airway inflammation in…”
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Structure, function and cellular expression of complement anaphylatoxin receptors by Wetsel, Rick A

“…The past year has seen significant advances in determining the important structural-functional domains of the complement C5a anaphylatoxin receptor. The…”
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Regulatory Role of C5a on Macrophage Migration Inhibitory Factor Release from Neutrophils by Riedemann, Niels C, Guo, Ren-Feng, Gao, Hongwei, Sun, Lei, Hoesel, Marco, Hollmann, Travis J, Wetsel, Rick A, Zetoune, Firas S, Ward, Peter A

“…There is evidence that C5a and macrophage migration inhibitory factor (MIF) both play important roles in experimental sepsis. Humans with sepsis also show…”
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Attenuation of Experimental Autoimmune Demyelination in Complement-Deficient Mice by Nataf, Serge, Carroll, Steven L, Wetsel, Rick A, Szalai, Alexander J, Barnum, Scott R

“…The exact mechanisms leading to CNS inflammation and myelin destruction in multiple sclerosis and in its animal model, experimental allergic encephalomyelitis…”
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Effect of Complement Component C3 Deficiency on Experimental Lyme Borreliosis in Mice by LAWRENZ, Matthew B, WOOTEN, R. Mark, ZACHARY, James F, DROUIN, Scott M, WEIS, Janis J, WETSEL, Rick A, NORRIS, Steven J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung by Haviland, DL, McCoy, RL, Whitehead, WT, Akama, H, Molmenti, EP, Brown, A, Haviland, JC, Parks, WC, Perlmutter, DH, Wetsel, RA

“…The small-complement C5 activation fragment, C5a, is a potent phlogistic molecule that, on binding to the C5a Receptor (C5aR), mediates contraction of smooth…”
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