Search Results - "Wetering, Koen"

Inorganic Pyrophosphate Deficiency Syndromes and Potential Treatments for Pathologic Tissue Calcification by Ralph, Douglas, van de Wetering, Koen, Uitto, Jouni, Li, Qiaoli

“…Pathologic soft tissue calcification can occur in both genetic and acquired clinical conditions, causing significant morbidity and mortality. Although the…”
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The Mineralization Regulator ANKH Mediates Cellular Efflux of ATP, Not Pyrophosphate by Szeri, Flora, Niaziorimi, Fatemeh, Donnelly, Sylvia, Fariha, Nishat, Tertyshnaia, Mariia, Patel, Drithi, Lundkvist, Stefan, Wetering, Koen

“…ABSTRACT The plasma membrane protein ankylosis homologue (ANKH, mouse ortholog: Ank) prevents pathological mineralization of joints by controlling…”
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Generation of fully functional fluorescent fusion proteins to gain insights into ABCC6 biology by Szeri, Flora, Niaziorimi, Fatemeh, Donnelly, Sylvia, Orndorff, Joseph, Wetering, Koen

“…ABCC6 mediates release of ATP from hepatocytes into the blood. Extracellularly, ATP is converted into the mineralization inhibitor pyrophosphate. Consequently,…”
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Multidrug resistance-associated proteins 3, 4, and 5 by Borst, Piet, de Wolf, Cornelia, van de Wetering, Koen

“…We summarize in this paper the recently published results on multidrug resistance-associated proteins 3, 4, and 5 (MRPs 3-5). MRP3 can transport organic…”
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ABCC6–Mediated ATP Secretion by the Liver Is the Main Source of the Mineralization Inhibitor Inorganic Pyrophosphate in the Systemic Circulation—Brief Report by Jansen, Robert S, Duijst, Suzanne, Mahakena, Sunny, Sommer, Daniela, Szeri, Flóra, Váradi, András, Plomp, Astrid, Bergen, Arthur A, Oude Elferink, Ronald P.J, Borst, Piet, van de Wetering, Koen

“…OBJECTIVE—Mutations in ABCC6 underlie the ectopic mineralization disorder pseudoxanthoma elasticum (PXE) and some forms of generalized arterial calcification…”
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Oral administration of pyrophosphate inhibits connective tissue calcification by Dedinszki, Dóra, Szeri, Flóra, Kozák, Eszter, Pomozi, Viola, Tőkési, Natália, Mezei, Tamás Róbert, Merczel, Kinga, Letavernier, Emmanuel, Tang, Ellie, Le Saux, Olivier, Arányi, Tamás, van de Wetering, Koen, Váradi, András

“…Various disorders including pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI), which are caused by inactivating mutations…”
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ABCG2 functions as a general phytoestrogen sulfate transporter in vivo by Wetering, Koen, Sapthu, Sunny

“…ABCG2 is an ATP‐dependent efflux transporter that limits the systemic exposure of its substrates. The preferred substrates of ABCG2 in vivo are largely…”
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Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice by Pomozi, Viola, Brampton, Christopher, van de Wetering, Koen, Zoll, Janna, Calio, Bianca, Pham, Kevin, Owens, Jesse B, Marh, Joel, Moisyadi, Stefan, Váradi, András, Martin, Ludovic, Bauer, Carolin, Erdmann, Jeanette, Aherrahrou, Zouhair, Le Saux, Olivier

“…Soft tissue calcification occurs in several common acquired pathologies, such as diabetes and hypercholesterolemia, or can result from genetic disorders…”
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Effects of Different Variants in the ENPP1 Gene on the Functional Properties of Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1 by Stella, Jacqueline, Buers, Insa, van de Wetering, Koen, Höhne, Wolfgang, Rutsch, Frank, Nitschke, Yvonne

“…ABSTRACT Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E‐NPP1), encoded by ENPP1, is a plasma membrane protein that generates inorganic…”
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Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging by Novais, Emanuel J., Tran, Victoria A., Miao, Jingya, Slaver, Katie, Sinensky, Andrew, Dyment, Nathaniel A., Addya, Sankar, Szeri, Flora, Wetering, Koen, Shapiro, Irving M., Risbud, Makarand V.

“…Intervertebral disc degeneration presents a wide spectrum of clinically degenerative disc phenotypes; however, the contribution of genetic background to the…”
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Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol by van de Wetering, Koen, Burkon, Alexander, Feddema, Wouter, Bot, Alice, de Jonge, Hugo, Somoza, Veronika, Borst, Piet

“…The phytoestrogen resveratrol has putative health-promoting effects and is present in several dietary constituents. Resveratrol is metabolized extensively in…”
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The pathogenic c.1171A>G (p.Arg391Gly) and c.2359G>A (p.Val787Ile) ABCC6 variants display incomplete penetrance causing pseudoxanthoma elasticum in a subset of individuals by Szeri, Flora, Miko, Agnes, Navasiolava, Nastassia, Kaposi, Ambrus, Verschuere, Shana, Molnar, Beatrix, Li, Qiaoli, Terry, Sharon F., Boraldi, Federica, Uitto, Jouni, Wetering, Koen, Martin, Ludovic, Quaglino, Daniela, Vanakker, Olivier M., Tory, Kalman, Aranyi, Tamas

“…ABCC6 promotes ATP efflux from hepatocytes to bloodstream. ATP is metabolized to pyrophosphate, an inhibitor of ectopic calcification. Pathogenic variants of…”
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Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays by Krumpochova, Petra, Sapthu, Sunny, Brouwers, Jos F., Haas, Marcel, Vos, Ric, Borst, Piet, Wetering, Koen

“…ABSTRACT The ATP‐binding cassette (ABC) genes encode the largest family of transmembrane proteins. ABC transporters translocate a wide variety of substrates…”
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Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer by Rottenberg, Sven, Nygren, Anders O.H, Pajic, Marina, van Leeuwen, Fijs W.B, van der Heijden, Ingrid, van de Wetering, Koen, Liu, Xiaoling, de Visser, Karin E, Gilhuijs, Kenneth G, van Tellingen, Olaf, Schouten, Jan P, Jonkers, Jos, Borst, Piet

“…We have studied in vivo responses of "spontaneous" Brca1- and p53-deficient mammary tumors arising in conditional mouse mutants to treatment with doxorubicin,…”
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Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells by van Veen, Michiel, Matas-Rico, Elisa, van de Wetering, Koen, Leyton-Puig, Daniela, Kedziora, Katarzyna M, De Lorenzi, Valentina, Stijf-Bultsma, Yvette, van den Broek, Bram, Jalink, Kees, Sidenius, Nicolai, Perrakis, Anastassis, Moolenaar, Wouter H

“…The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and…”
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MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum by Rijpma, Sanna R., Velden, Maarten, Bilos, Albert, Jansen, Robert S., Mahakena, Sunny, Russel, Frans G. M., Sauerwein, Robert W., Wetering, Koen, Koenderink, Jan B., Mantei, Ned

“…Multidrug resistance‐associated proteins (MRP) of Plasmodium falciparum have been associated with altered drug sensitivity. Knowledge on MRP substrate…”
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ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: Relevance to pathomechanisms of pseudoxanthoma elasticum by Fülöp, Krisztina, Jiang, Qiujie, Wetering, Koen v.d., Pomozi, Viola, Szabó, Pál T., Arányi, Tamás, Sarkadi, Balázs, Borst, Piet, Uitto, Jouni, Váradi, András

“…► The substrate of ABCC6 preventing soft tissue calcification is not known. ► It was proposed that vitamin K3-glutathione conjugate is the physiological…”
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Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides by de Wolf, Cornelia, Jansen, Robert, Yamaguchi, Hiroaki, de Haas, Marcel, van de Wetering, Koen, Wijnholds, Jan, Beijnen, Jos, Borst, Piet

“…We have studied the potential contribution of ABCG2 (breast cancer resistance protein) to resistance to nucleoside analogues. In cells transfected with DNA…”
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Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides by Zelcer, Noam, Wetering, Koen van de, Waart, Rudi de, Scheffer, George L., Marschall, Hanns-Ulrich, Wielinga, Peter R., Kuil, Annemieke, Kunne, Cindy, Smith, Alexander, Valk, Martin van der, Wijnholds, Jan, Elferink, Ronald Oude, Borst, Piet

“…Multidrug Resistance Protein 3 (MRP3) transports bile salts and glucuronide conjugates in vitro and is postulated to protect the liver in cholestasis. Whether…”
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Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum by Li, Qiaoli, Kingman, Joshua, van de Wetering, Koen, Tannouri, Sami, Sundberg, John P., Uitto, Jouni

“…Pseudoxanthoma elasticum, a heritable ectopic mineralization disorder, is caused by mutations in the ABCC6 gene primarily expressed in the liver and the…”
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