Search Results - "Westwick, John K"

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth by Murray, Brion W, Guo, Chuangxing, Piraino, Joseph, Westwick, John K, Zhang, Cathy, Lamerdin, Jane, Dagostino, Eleanor, Knighton, Daniel, Loi, Cho-Ming, Zager, Michael, Kraynov, Eugenia, Popoff, Ian, Christensen, James G, Martinez, Ricardo, Kephart, Susan E, Marakovits, Joseph, Karlicek, Shannon, Bergqvist, Simon, Smeal, Tod

“…Despite abundant evidence that aberrant Rho-family GTPase activation contributes to most steps of cancer initiation and progression, there is a dearth of…”
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Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase by Ding, Zhiyong, Liang, Jiyong, Li, Jin, Lu, Yiling, Ariyaratna, Vathsala, Lu, Zhimin, Davies, Michael A, Westwick, John K, Mills, Gordon B

“…Frequent activation of the AKT serine-threonine kinase in cancer confers resistance to therapy. AKT is activated by a multi-step process involving…”
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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K by Keely, Patricia J, Westwick, John K, Whitehead, Ian P, Der, Channing J, Parise, Leslie V

“…Transformation of mammary epithelial cells into invasive carcinoma results in alterations in their integrin-mediated responses to the extracellular matrix,…”
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Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase by Ennis, Bruce W, Fultz, Kimberly E, Smith, Kent A, Westwick, John K, Zhu, Dan, Boluro-Ajayi, Michael, Bilter, Graham K, Stein, Bernd

“…c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family, and its function is critical for signal transduction in tumor and…”
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Raf-independent Deregulation of p38 and JNK Mitogen-activated Protein Kinases Are Critical for Ras Transformation by Pruitt, Kevin, Pruitt, Wendy M, Bilter, Graham K, Westwick, John K, Der, Channing J

“…Activated Ras, but not Raf, causes transformation of RIE-1 epithelial cells, supporting the importance of Raf-independent pathways in mediating Ras…”
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Identifying off-target effects and hidden phenotypes of drugs in human cells by Michnick, Stephen W, Westwick, John K, MacDonald, Marnie L, Lamerdin, Jane, Owens, Stephen, Keon, Brigitte H, Bilter, Graham K, Shang, Zhidi, Huang, Zhengping, Yu, Helen, Dias, Jennifer, Minami, Tomoe

“…We present a strategy for identifying off-target effects and hidden phenotypes of drugs by directly probing biochemical pathways that underlie therapeutic or…”
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JNK mediates hepatic ischemia reperfusion injury by Uehara, Tetsuya, Bennett, Brydon, Sakata, Steve T., Satoh, Yoshitaka, Bilter, Graham K., Westwick, John K., Brenner, David A.

“…Hepatic ischemia followed by reperfusion (I/R) is a major clinical problem during transplantation, liver resection for tumor, and circulatory shock, producing…”
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Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle by Mettouchi, Amel, Klein, Sharon, Guo, Wenjun, Lopez-Lago, Miguel, Lemichez, Emmanuel, Westwick, John K., Giancotti, Filippo G.

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Measuring drug action in the cellular context using protein-fragment complementation assays by Yu, Helen, West, Mary, Keon, Brigitte H, Bilter, Graham K, Owens, Stephen, Lamerdin, Jane, Westwick, John K

“…Cellular signal transduction occurs in the context of dynamic multiprotein complexes in highly ramified pathways. These complexes in turn interact with the…”
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Defining Estrogenic Mechanisms of Bisphenol A Analogs through High Throughput Microscopy-Based Contextual Assays by Stossi, Fabio, Bolt, Michael J., Ashcroft, Felicity J., Lamerdin, Jane E., Melnick, Jonathan S., Powell, Reid T., Dandekar, Radhika D., Mancini, Maureen G., Walker, Cheryl L., Westwick, John K., Mancini, Michael A.

“…Environmental exposures to chemically heterogeneous endocrine-disrupting chemicals (EDCs) mimic or interfere with hormone actions and negatively affect human…”
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The coupling of α6β4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation by Mainiero, Fabrizio, Murgia, Chiara, Wary, Kishore K., Curatola, Anna Maria, Pepe, Angela, Blumemberg, Miroslav, Westwick, John K., Der, Channing J., Giancotti, Filippo G.

“…The signaling pathways linking integrins to nuclear events are incompletely understood. We have examined intracellular signaling by the α6β4 integrin, a…”
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Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways by Westwick, John K., Lambert, Que T., Clark, Geoffrey J., Symons, Marc, Van Aelst, Linda, Pestell, Richard G., Der, Channing J.

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Ceramide Activates the Stress-activated Protein Kinases by Westwick, J K, Bielawska, A E, Dbaibo, G, Hannun, Y A, Brenner, D A

“…Tumor necrosis factor α (TNFα) activates the stress-activated protein kinases (SAPKs, also known as Jun nuclear kinases or JNKs) resulting in the stimulation…”
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Lck regulates Vav activation of members of the Rho family of GTPases by Han, Jaewon, Das, Balaka, Wei, Wen, Van Aelst, Linda, Mosteller, Raymond D., Khosravi-Far, Roya, Westwick, John K., Der, Channing J., Broek, Daniel

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Chemical genetic strategies to delineate MAP kinase signaling pathways using protein-fragment complementation assays (PCA) by Michnick, Stephen W., MacDonald, Marnie L., Westwick, John K.

“…Signal transduction pathways mediated by MAP kinases are among the most studied. Direct analysis of MAP kinase pathways has been difficult because some details…”
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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation by Khosravi-Far, Roya, White, Michael A., Westwick, John K., Solski, Patricia A., Chrzanowska-Wodnicka, Magdalena, Van Aelst, Linda, Wigler, Michael H., Der, Channing J.

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Exploiting network biology to improve drug discovery by MacDonald, Marnie L, Westwick, John K

“…Mammalian signal transduction occurs in the context of multiprotein complexes, yet currently available drug discovery strategies do not reflect this fact. We…”
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p120 GAP Modulates Ras Activation of Jun Kinases and Transformation by Clark, Geoffrey J., Westwick, John K., Der, Channing J.

“…Although recent evidence demonstrates that Ras causes transformation by activation of multiple downstream pathways, the specific role of non-Raf effector…”
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Isolation of a NCK-associated Kinase, PRK2, an SH3-binding Protein and Potential Effector of Rho Protein Signaling by Quilliam, L A, Lambert, Q T, Mickelson-Young, L A, Westwick, J K, Sparks, A B, Kay, B K, Jenkins, N A, Gilbert, D J, Copeland, N G, Der, C J

“…The NCK adapter protein is comprised of three consecutive Src homology 3 (SH3) protein-protein interaction domains and a C-terminal SH2 domain. Although the…”
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Oncogenic Ras Activates c-Jun Via a Separate Pathway from the Activation of Extracellular Signal-Regulated Kinases by Westwick, John K., Cox, Adrienne D., Der, Channing J., Cobb, Melanie H., Hibi, Masahiko, Karin, Michael, Brenner, David A.

“…c-Jun transcriptional activity is augmented by expression of oncogenic Ras and Raf proteins. This study demonstrates a direct correlation between Ras…”
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