Search Results - "Westra, R."

Evolutionary Ecology of Prokaryotic Immune Mechanisms by van Houte, Stineke, Buckling, Angus, Westra, Edze R

“…Bacteria have a range of distinct immune strategies that provide protection against bacteriophage (phage) infections. While much has been learned about the…”
Get full text

Prophages mediate defense against phage infection through diverse mechanisms by Bondy-Denomy, Joseph, Qian, Jason, Westra, Edze R, Buckling, Angus, Guttman, David S, Davidson, Alan R, Maxwell, Karen L

“…The activity of bacteriophages poses a major threat to bacterial survival. Upon infection, a temperate phage can either kill the host cell or be maintained as…”
Get full text

CRISPR-Cas antimicrobials: Challenges and future prospects by Pursey, Elizabeth, Sünderhauf, David, Gaze, William H, Westra, Edze R, van Houte, Stineke

“…[...]it is well established that stress-induced alterations to microbial community composition and metabolite levels are associated with an increase in…”
Get full text

Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense by Westra, Edze R., van Houte, Stineke, Oyesiku-Blakemore, Sam, Makin, Ben, Broniewski, Jenny M., Best, Alex, Bondy-Denomy, Joseph, Davidson, Alan, Boots, Mike, Buckling, Angus

“…In the face of infectious disease, organisms evolved a range of defense mechanisms, with a clear distinction between those that are constitutive (always…”
Get full text

Various plasmid strategies limit the effect of bacterial restriction-modification systems against conjugation by Dimitriu, Tatiana, Szczelkun, Mark D, Westra, Edze R

“…In bacteria, genes conferring antibiotic resistance are mostly carried on conjugative plasmids, mobile genetic elements that spread horizontally between…”
Get full text

Evolutionary emergence of infectious diseases in heterogeneous host populations by Chabas, Hélène, Lion, Sébastien, Nicot, Antoine, Meaden, Sean, van Houte, Stineke, Moineau, Sylvain, Wahl, Lindi M, Westra, Edze R, Gandon, Sylvain

“…The emergence and re-emergence of pathogens remains a major public health concern. Unfortunately, when and where pathogens will (re-)emerge is notoriously…”
Get full text

Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence by Semenova, Ekaterina, Jore, Matthijs M, Datsenko, Kirill A, Semenova, Anna, Westra, Edze R, Wanner, Barry, van der Oost, John, Brouns, Stan J.J, Severinov, Konstantin

“…Prokaryotic clustered regularly interspaced short palindromic repeat (CRISPR)/Cas (CRISPR-associated sequences) systems provide adaptive immunity against…”
Get full text

Two Distinct DNA Binding Modes Guide Dual Roles of a CRISPR-Cas Protein Complex by Blosser, Timothy R., Loeff, Luuk, Westra, Edze R., Vlot, Marnix, Künne, Tim, Sobota, Małgorzata, Dekker, Cees, Brouns, Stan J.J., Joo, Chirlmin

“…Small RNA-guided protein complexes play an essential role in CRISPR-mediated immunity in prokaryotes. While these complexes initiate interference by flagging…”
Get full text

CRISPR-based adaptive and heritable immunity in prokaryotes by van der Oost, John, Jore, Matthijs M., Westra, Edze R., Lundgren, Magnus, Brouns, Stan J.J.

“…The recently discovered CRISPR (clustered regularly interspaced short palindromic repeat) defense system protects bacteria and archaea against mobile genetic…”
Get full text

Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition by Westra, Edze R, Semenova, Ekaterina, Datsenko, Kirill A, Jackson, Ryan N, Wiedenheft, Blake, Severinov, Konstantin, Brouns, Stan J J

“…Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci…”
Get full text

Type I-F CRISPR-Cas resistance against virulent phages results in abortive infection and provides population-level immunity by Watson, Bridget N. J., Vercoe, Reuben B., Salmond, George P. C., Westra, Edze R., Staals, Raymond H. J, Fineran, Peter C.

“…Type I CRISPR-Cas systems are abundant and widespread adaptive immune systems in bacteria and can greatly enhance bacterial survival in the face of phage…”
Get full text

Individual bacteria in structured environments rely on phenotypic resistance to phage by Attrill, Erin L, Claydon, Rory, Łapińska, Urszula, Recker, Mario, Meaden, Sean, Brown, Aidan T, Westra, Edze R, Harding, Sarah V, Pagliara, Stefano

“…Bacteriophages represent an avenue to overcome the current antibiotic resistance crisis, but evolution of genetic resistance to phages remains a concern. In…”
Get full text

The impact of phage and phage resistance on microbial community dynamics by Alseth, Ellinor O, Custodio, Rafael, Sundius, Sarah A, Kuske, Rachel A, Brown, Sam P, Westra, Edze R

“…Where there are bacteria, there will be bacteriophages. These viruses are known to be important players in shaping the wider microbial community in which they…”
Get full text

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes by Brouns, Stan J.J, Jore, Matthijs M, Lundgren, Magnus, Westra, Edze R, Slijkhuis, Rik J.H, Snijders, Ambrosius P.L, Dickman, Mark J, Makarova, Kira S, Koonin, Eugene V, van der Oost, John

“…Prokaryotes acquire virus resistance by integrating short fragments of viral nucleic acid into clusters of regularly interspaced short palindromic repeats…”
Get full text

Searching for ring-like structures in the cosmic microwave background by López, M, Bonizzi, P, Driessens, K, Koekoek, G, de Vries, J A, Westra, R

“…In this research, we present an alternative methodology to search for ring-like structures in the sky with unusually large temperature gradients, namely,…”
Get full text

Phage gene expression and host responses lead to infection-dependent costs of CRISPR immunity by Meaden, Sean, Capria, Loris, Alseth, Ellinor, Gandon, Sylvain, Biswas, Ambarish, Lenzi, Luca, van Houte, Stineke, Westra, Edze R.

“…CRISPR-Cas immune systems are widespread in bacteria and archaea, but not ubiquitous. Previous work has demonstrated that CRISPR immunity is associated with an…”
Get full text

Effects of Argonaute on Gene Expression in Thermus thermophilus by Swarts, Daan C, Koehorst, Jasper J, Westra, Edze R, Schaap, Peter J, van der Oost, John

“…Eukaryotic Argonaute proteins mediate RNA-guided RNA interference, allowing both regulation of host gene expression and defense against invading mobile genetic…”
Get full text

Determination of Acr-mediated immunosuppression in Pseudomonas aeruginosa by Pons, Benoit J., Westra, Edze R., van Houte, Stineke

“…Bacteria have a broad array of defence mechanisms to fight bacteria-specific viruses (bacteriophages, phages) and other invading mobile genetic elements. Among…”
Get full text

Native Tandem and Ion Mobility Mass Spectrometry Highlight Structural and Modular Similarities in Clustered-Regularly-Interspaced Shot-Palindromic-Repeats (CRISPR)-associated Protein Complexes From Escherichia coli and Pseudomonas aeruginosa by van Duijn, Esther, Barbu, Ioana M., Barendregt, Arjan, Jore, Matthijs M., Wiedenheft, Blake, Lundgren, Magnus, Westra, Edze R., Brouns, Stan J.J., Doudna, Jennifer A., van der Oost, John, Heck, Albert J.R.

“…The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated genes) immune system of bacteria and archaea provides acquired…”
Get full text

Trends in co-prescribed opioids and benzodiazepines, non-prescribed opioids and benzodiazepines, and schedule-I drugs in the United States, 2013 to 2019 by Taha, Shaden A., Westra, Jordan R., Tacker, Danyel H., Raji, Mukaila A., Kuo, Yong-Fang

“…•Concurrent opioid and benzodiazepine use in United States adults decreased from 19.3% in 2013, to 9.8% in 2019.•Concurrent use decreased at a greater rate…”
Get full text