Search Results - "Westphal, V."

Evaluation of tert-Butyl Isosteres: Case Studies of Physicochemical and Pharmacokinetic Properties, Efficacies, and Activities by Westphal, Matthias V., Wolfstädter, Bernd T., Plancher, Jean-Marc, Gatfield, John, Carreira, Erick M.

“…The tert‐butyl group is a common motif in medicinal chemistry. Its incorporation into bioactive compounds is often accompanied by unwanted property modulation,…”
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Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease by Ruiz de Martín Esteban, Samuel, Benito-Cuesta, Irene, Terradillos, Itziar, Martínez-Relimpio, Ana M., Arnanz, M. Andrea, Ruiz-Pérez, Gonzalo, Korn, Claudia, Raposo, Catarina, Sarott, Roman C., Westphal, Matthias V., Elezgarai, Izaskun, Carreira, Erick M., Hillard, Cecilia J., Grether, Uwe, Grandes, Pedro, Grande, M. Teresa, Romero, Julián

“…The distribution and roles of the cannabinoid CB 2 receptor in the CNS are still a matter of debate. Recent data suggest that, in addition to its presence in…”
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A protocol for registration and correction of multicolour STED superresolution images by HEBISCH, E., WAGNER, E., WESTPHAL, V., SIEBER, J.J., LEHNART, S.E.

“…Summary Multicolour fluorescence imaging by STimulated Emission Depletion (STED) superresolution microscopy with doughnut‐shaped STED laser beams based on…”
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Lacticaseibacillus rhamnosus GG DSM 33156 effects on pathogen defence in the upper respiratory tract: a randomised, double-blind, placebo-controlled paediatric trial by Damholt, A, Keller, M K, Baranowski, K, Brown, B, Wichmann, A, Melsaether, C, Eskesen, D, Westphal, V, Arltoft, D, Habicht, A, Gao, Q, Crawford, G

“…Acute upper respiratory tract infections (URTIs) are caused by numerous viruses and bacteria. URTIs can be a cause of morbidity and are among the most common…”
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Lateral resolution of 28 nm (λ /25) in far-field fluorescence microscopy by Westphal, V., Kastrup, L., Hell, S.W.

“…We demonstrate sub-diffraction lateral resolution of 28c2 nm in far-field fluorescence microscopy through stimulated emission depletion effected by an…”
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Diffuse phase transitions and random-field-induced domain states of the relaxor ferroelectric PbMg1/3Nb2/3O3 by WESTPHAL, V, KLEEMANN, W, GLINCHUK, M. D

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Dynamic far-field fluorescence nanoscopy by Westphal, V, Lauterbach, M A, Di Nicola, A, Hell, S W

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Water-Compatible Cycloadditions of Oligonucleotide-Conjugated Strained Allenes for DNA-Encoded Library Synthesis by Westphal, Matthias V, Hudson, Liam, Mason, Jeremy W, Pradeilles, Johan A, Zécri, Frédéric J, Briner, Karin, Schreiber, Stuart L

“…DNA-encoded libraries of small molecules are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial…”
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Two Proteins Modulating Transendothelial Migration of Leukocytes Recognize Novel Carboxylated Glycans on Endothelial Cells by Srikrishna, Geetha, Panneerselvam, Krishnasamy, Westphal, Vibeke, Abraham, Violet, Varki, Ajit, Freeze, Hudson H

“…We recently showed that a class of novel carboxylated N:-glycans was constitutively expressed on endothelial cells. Activated, but not resting, neutrophils…”
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Laser-diode-stimulated emission depletion microscopy by Westphal, V., Blanca, C. M., Dyba, M., Kastrup, L., Hell, S. W.

“…We report subdiffraction resolution in far-field fluorescence microscopy through laser-diode-stimulated emission depletion of molecular markers. The…”
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Mutations in PMM2 that cause congenital disorders of glycosylation, type Ia (CDG-Ia) by Matthijs, G., Schollen, E., Bjursell, C., Erlandson, A., Freeze, H., Imtiaz, F., Kjaergaard, S., Martinsson, T., Schwartz, M., Seta, N., Vuillaumier-Barrot, S., Westphal, V., Winchester, B.

“…The PMM2 gene, which is defective in CDG‐Ia, was cloned three years ago [Matthijs et al., 1997b]. Several publications list PMM2 mutations [Matthijs et al.,…”
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DNA-encoded library-enabled discovery of proximity-inducing small molecules by Mason, Jeremy W., Chow, Yuen Ting, Hudson, Liam, Tutter, Antonin, Michaud, Gregory, Westphal, Matthias V., Shu, Wei, Ma, Xiaolei, Tan, Zher Yin, Coley, Connor W., Clemons, Paul A., Bonazzi, Simone, Berst, Frédéric, Briner, Karin, Liu, Shuang, Zécri, Frédéric J., Schreiber, Stuart L.

“…Small molecules that induce protein–protein associations represent powerful tools to modulate cell circuitry. We sought to develop a platform for the direct…”
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Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells by Soethoudt, Marjolein, Stolze, Sara C, Westphal, Matthias V, van Stralen, Luuk, Martella, Andrea, van Rooden, Eva J, Guba, Wolfgang, Varga, Zoltan V, Deng, Hui, van Kasteren, Sander I, Grether, Uwe, IJzerman, Adriaan P, Pacher, Pal, Carreira, Erick M, Overkleeft, Herman S, Ioan-Facsinay, Andreea, Heitman, Laura H, van der Stelt, Mario

“…Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression levels and receptor occupancy by small molecules are highly desirable…”
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Highly Selective, Amine‐Derived Cannabinoid Receptor 2 Probes by Westphal, Matthias V., Sarott, Roman C., Zirwes, Elisabeth A., Osterwald, Anja, Guba, Wolfgang, Ullmer, Christoph, Grether, Uwe, Carreira, Erick M.

“…The endocannabinoid (eCB) system is implied in various human diseases ranging from central nervous system to autoimmune disorders. Cannabinoid receptor 2…”
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High-resolution endoscopic imaging of the GI tract: A comparative study of optical coherence tomography versus high-frequency catheter probe EUS by Das, Ananya, Sivak, Michael V., Chak, Amitabh, Wong, Richard C.K., Westphal, Volker, Rollins, Andrew M., Willis, Joseph, Isenberg, Gerard, Izatt, Joseph A.

“…Background: Both optical coherence tomography (OCT) and catheter probe EUS (CPEUS) are candidates for high-resolution imaging of the GI wall, but their…”
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Balancing N-linked glycosylation to avoid disease by Freeze, Hudson H., Westphal, Vibeke

“…Complete loss of N-glycosylation is lethal in both yeast and mammals. Substantial deficiencies in some rate-limiting biosynthetic steps cause human congenital…”
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Diversity-oriented synthesis encoded by deoxyoligonucleotides by Hudson, Liam, Mason, Jeremy W., Westphal, Matthias V., Richter, Matthieu J. R., Thielman, Jonathan R., Hua, Bruce K., Gerry, Christopher J., Xia, Guoqin, Osswald, Heather L., Knapp, John M., Tan, Zher Yin, Kokkonda, Praveen, Tresco, Ben I. C., Liu, Shuang, Reidenbach, Andrew G., Lim, Katherine S., Poirier, Jennifer, Capece, John, Bonazzi, Simone, Gampe, Christian M., Smith, Nichola J., Bradner, James E., Coley, Connor W., Clemons, Paul A., Melillo, Bruno, Hon, C. Suk-Yee, Ottl, Johannes, Dumelin, Christoph E., Schaefer, Jonas V., Faust, Ann Marie E., Berst, Frédéric, Schreiber, Stuart L., Zécri, Frédéric J., Briner, Karin

“…Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in…”
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Measurements of skin friction and heat transfer beneath an impinging slot jet by Dogruoz, M. Baris, Ortega, Alfonso, Westphal, Russell V.

“…•Investigating turbulent slot jet impingement within jet potential core length.•Conducting pressure, velocity, wall skin friction and heat transfer…”
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Real-time optical coherence tomography of the anterior segment at 1310 nm by Radhakrishnan, S, Rollins, A M, Roth, J E, Yazdanfar, S, Westphal, V, Bardenstein, D S, Izatt, J A

“…Recent advances in high-speed scanning technology have enabled a new generation of optical coherence tomographic (OCT) systems to perform imaging at video…”
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Synthesis of Photoswitchable Δ 9 -Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling by Westphal, Matthias V, Schafroth, Michael A, Sarott, Roman C, Imhof, Michael A, Bold, Christian P, Leippe, Philipp, Dhopeshwarkar, Amey, Grandner, Jessica M, Katritch, Vsevolod, Mackie, Ken, Trauner, Dirk, Carreira, Erick M, Frank, James A

“…The cannabinoid receptor 1 (CB1) is an inhibitory G protein-coupled receptor abundantly expressed in the central nervous system. It has rich pharmacology and…”
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