Search Results - "Westphal, Koen G.C"

Lipopolysaccharide-induced anhedonia is abolished in male serotonin transporter knockout rats: An intracranial self-stimulation study by van Heesch, Floor, Prins, Jolanda, Konsman, Jan Pieter, Westphal, Koen G.C, Olivier, Berend, Kraneveld, Aletta D, Korte, S. Mechiel

“…Highlight ► LPS-induced anhedonia is abolished in SERT−/− rats, suggesting that increased activity of SERT during inflammation plays a role in the development…”
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Stress-induced hyperthermia and infection-induced fever: Two of a kind? by Vinkers, Christiaan H, Groenink, Lucianne, van Bogaert, Meg J.V, Westphal, Koen G.C, Kalkman, Cor J, van Oorschot, Ruud, Oosting, Ronald S, Olivier, Berend, Korte, S. Mechiel

“…Abstract Stress exposure activates the autonomic nervous system and leads to a body temperature increase (stress-induced hyperthermia, SIH). On the other hand,…”
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The 5-HT1A/1B-receptor agonist eltoprazine increases both catecholamine release in the prefrontal cortex and dopamine release in the nucleus accumbens and decreases motivation for reward and “waiting” impulsivity, but increases “stopping” impulsivity by Korte, S. Mechiel, Prins, Jolanda, Van den Bergh, Filip S., Oosting, Ronald S., Dupree, Rudy, Korte-Bouws, Gerdien A.H., Westphal, Koen G.C., Olivier, Berend, Denys, Damiaan A., Garland, Alexis, Güntürkün, Onur

“…The 5-HT1A/1B-receptor agonist eltoprazine has a behavioral drug signature that resembles that of a variety of psychostimulant drugs, despite the differences…”
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Medial amygdala lesions differentially influence stress responsivity and sensorimotor gating in rats by Vinkers, Christiaan H, Bijlsma, Elisabeth Y, Houtepen, Lotte C, Westphal, Koen G.C, Veening, Jan G, Groenink, Lucianne, Olivier, Berend

“…Abstract Background The amygdala is involved in the coordination of stress but is also an important gatekeeper involved in the regulation of vigilance. The…”
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The autonomic stress-induced hyperthermia response is not enhanced by several anxiogenic drugs by Houtepen, Lotte C, Peterse, Daniëlle P, Westphal, Koen G.C, Olivier, Berend, Vinkers, Christiaan H

“…Abstract While anxiety models are often based on locomotor activity responses, the stress-induced hyperthermia (SIH) paradigm uses the autonomic stress…”
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Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids by Slingerland, Cornelis J., Wesseling, Charlotte M. J., Innocenti, Paolo, Westphal, Koen G. C., Masereeuw, Rosalinde, Martin, Nathaniel I.

“…Polymyxins are a class of lipopeptide anti-infective agents with potent and specific activity against Gram-negative bacteria. While toxicity concerns…”
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Recellularized Native Kidney Scaffolds as a Novel Tool in Nephrotoxicity Screening by Fedecostante, Michele, Westphal, Koen G C, Buono, Michele F, Sanchez Romero, Natalia, Wilmer, Martijn J, Kerkering, Janis, Baptista, Pedro Miguel, Hoenderop, Joost G, Masereeuw, Rosalinde

“…Drug-induced kidney injury in medicinal compound development accounts for over 20% of clinical trial failures and involves damage to different nephron…”
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Towards a Bioengineered Kidney: Recellularization Strategies for Decellularized Native Kidney Scaffolds by Fedecostante, Michele, Onciu, Oana G., Westphal, Koen G.C., Masereeuw, Rosalinde

“…Patients with end-stage renal disease often undergo dialysis as a partial substitute for kidney function while waiting for their only treatment option: a…”
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Lipopolysaccharide increases degradation of central monoamines: An in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice by van Heesch, Floor, Prins, Jolanda, Konsman, Jan Pieter, Korte-Bouws, Gerdien A.H., Westphal, Koen G.C., Rybka, Joanna, Olivier, Berend, Kraneveld, Aletta D., Korte, S. Mechiel

“…Peripheral administration of lipopolysaccharide (LPS) in rodents induces anhedonia, i.e. the inability to experience pleasure. Recently, we reported that…”
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Akt1 Deficiency Affects Neuronal Morphology and Predisposes to Abnormalities in Prefrontal Cortex Functioning by Lai, Wen-Sung, Xu, Bin, Westphal, Koen G. C., Paterlini, Marta, Olivier, Berend, Pavlidis, Paul, Karayiorgou, Maria, Gogos, Joseph A.

“…There is accumulating evidence that AKT signaling plays a role in the pathogenesis of schizophrenia. We asked whether Aktl deficiency in mice results in…”
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Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice by Karayiorgou, Maria, Gogos, Joseph A, Paterlini, Marta, Zakharenko, Stanislav S, Lai, Wen-Sung, Qin, Jie, Zhang, Hui, Mukai, Jun, Westphal, Koen G C, Olivier, Berend, Sulzer, David, Pavlidis, Paul, Siegelbaum, Steven A

“…Microdeletions of 22q11.2 represent one of the highest known genetic risk factors for schizophrenia. It is likely that more than one gene contributes to the…”
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Systemic tumor necrosis factor-alpha decreases brain stimulation reward and increases metabolites of serotonin and dopamine in the nucleus accumbens of mice by van Heesch, Floor, Prins, Jolanda, Korte-Bouws, Gerdien A.H., Westphal, Koen G.C., Lemstra, Suzanne, Olivier, Berend, Kraneveld, Aletta D., Korte, S. Mechiel

“…•Peripherally injected TNF-alpha induces anhedonia in mice.•Accumbal extracellular 5-HIAA levels increase in response to peripheral TNF-alpha.•Accumbal…”
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Re-exposure and environmental enrichment reveal NPY-Y1 as a possible target for post-traumatic stress disorder by Hendriksen, Hendrikus, Bink, Diewertje I., Daniels, Eileen G., Pandit, Rahul, Piriou, Carole, Slieker, Roderick, Westphal, Koen G.C., Olivier, Berend, Oosting, Ronald S.

“…Exposure-based cognitive behavioral therapy in post-traumatic stress disorder (PTSD) patients relieves symptoms caused by fear association as well as symptoms…”
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Environmental enrichment has antidepressant-like action without improving learning and memory deficits in olfactory bulbectomized rats by Hendriksen, Hendrikus, Meulendijks, Didier, Douma, Tessa N., Bink, Diewertje I., Breuer, Megan E., Westphal, Koen G.C., Olivier, Berend, Oosting, Ronald S.

“…Depression, especially in the elderly, is associated with poor cognitive functioning. Exercise has received much attention in the treatment for depression and…”
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Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats by Korte-Bouws, Gerdien A H, van Heesch, Floor, Westphal, Koen G C, Ankersmit, Lisa M J, van Oosten, Edwin M, Güntürkün, Onur, Korte, S Mechiel

“…It is well known that bacterial lipopolysaccharides (LPS) both increases proinflammatory cytokines and produces sickness behavior, including fatigue and…”
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Celecoxib delays cognitive decline in an animal model of neurodegeneration by Borre, Yuliya, Lemstra, Susan, Westphal, Koen G.C., Morgan, Mary E., Olivier, Berend, Oosting, Ronald S.

“…► We demonstrated involvement of COX-2 in the onset of the olfactory-induced cognitive and behavioral deficits. ► We examined effects of celecoxib, COX-2…”
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Serotonin release in the caudal nidopallium of adult laying hens genetically selected for high and low feather pecking behavior: An in vivo microdialysis study by Kops, Marjolein S., Kjaer, Joergen B., Güntürkün, Onur, Westphal, Koen G.C., Korte-Bouws, Gerdien A.H., Olivier, Berend, Bolhuis, J. Elizabeth, Korte, S. Mechiel

“…•Selection on high and low feather pecking (FP) affects serotonergic brain levels.•High FP (HFP) had higher serotonin release in the caudal nidopallium than…”
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The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties by Caldarone, Barbara J, Paterson, Neil E, Zhou, Jia, Brunner, Daniela, Kozikowski, Alan P, Westphal, Koen G C, Korte-Bouws, Gerdien A H, Prins, Jolanda, Korte, S Mechiel, Olivier, Berend, Ghavami, Afshin

“…Triple reuptake inhibitors (TRIs) that block the dopamine transporter (DAT), norepinephrine transporter, and serotonin transporter are being developed as a new…”
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A combined microphysiological-computational omics approach in dietary protein evaluation by Jochems, Paulus G. M., Keusters, Willem R., America, Antoine H. P., Rietveld, Pascale C. S., Bastiaan-Net, Shanna, Ariëns, Renata M. C., Tomassen, Monic M. M., Lewis, Fraser, Li, Yang, Westphal, Koen G. C., Garssen, Johan, Wichers, Harry J., van Bergenhenegouwen, Jeroen, Masereeuw, Rosalinde

“…Food security is under increased pressure due to the ever-growing world population. To tackle this, alternative protein sources need to be evaluated for…”
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Combination of Testosterone and Vardenafil Increases Female Sexual Functioning in Sub‐Primed Rats by Snoeren, Eelke M.S., Bovens, Astrid, Refsgaard, Louise K., Westphal, Koen G.C., Waldinger, Marcel D., Olivier, Berend, Oosting, Ronald S.

“…Hypoactive sexual desire disorder (HSDD) is a common problem in women and may have a negative impact on quality of life. A recent clinical study shows an…”
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