Search Results - "Westover, D"

Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors by Westover, D, Zugazagoitia, J, Cho, B C, Lovly, C M, Paz-Ares, L

“…Abstract Patients with non-small-cell lung cancer (NSCLC) whose tumours harbour activating mutations within the epidermal growth factor receptor (EGFR)…”
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Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition by Taipale, Mikko, Krykbaeva, Irina, Koeva, Martina, Kayatekin, Can, Westover, Kenneth D., Karras, Georgios I., Lindquist, Susan

“…HSP90 is a molecular chaperone that associates with numerous substrate proteins called clients. It plays many important roles in human biology and medicine,…”
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Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations by Hunter, John C, Manandhar, Anuj, Carrasco, Martin A, Gurbani, Deepak, Gondi, Sudershan, Westover, Kenneth D

“…KRAS mutations are the most common genetic abnormalities in cancer, but the distribution of specific mutations across cancers and the differential responses of…”
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KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS by Ambrogio, Chiara, Köhler, Jens, Zhou, Zhi-Wei, Wang, Haiyun, Paranal, Raymond, Li, Jiaqi, Capelletti, Marzia, Caffarra, Cristina, Li, Shuai, Lv, Qi, Gondi, Sudershan, Hunter, John C., Lu, Jia, Chiarle, Roberto, Santamaría, David, Westover, Kenneth D., Jänne, Pasi A.

“…The mechanism by which the wild-type KRAS allele imparts a growth inhibitory effect to oncogenic KRAS in various cancers, including lung adenocarcinoma (LUAD),…”
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Neutrophil-lymphocyte and platelet-lymphocyte ratios as prognostic factors after stereotactic radiation therapy for early-stage non-small-cell lung cancer by Cannon, Nathan A, Meyer, Jeffrey, Iyengar, Puneeth, Ahn, Chul, Westover, Kenneth D, Choy, Hak, Timmerman, Robert

“…The hematologic indices of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are correlated with clinical outcomes after stereotactic…”
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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate by Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Vander Heiden, Matthew G, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M

“…A quantitative high-throughput screen identified an inhibitor of phosphoglycerate dehydrogenase (PHGDH), a key enzyme for serine synthesis. This inhibitor…”
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In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C by Hunter, John C., Gurbania, Deepak, Ficarro, Scott B., Carrasco, Martin A., Lim, Sang Min, Choi, Hwan Geun, Xie, Ting, Marto, Jarrod A., Chen, Zhe, Gray, Nathanael S., Westover, Kenneth D.

“…Directly targeting oncogenic V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-Ras) with small-molecule inhibitors has historically been considered…”
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Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype by Olson, Calla M, Liang, Yanke, Leggett, Alan, Park, Woojun D, Li, Lianbo, Mills, Caitlin E, Elsarrag, Selma Z, Ficarro, Scott B, Zhang, Tinghu, Düster, Robert, Geyer, Matthias, Sim, Taebo, Marto, Jarrod A, Sorger, Peter K, Westover, Ken D, Lin, Charles Y, Kwiatkowski, Nicholas, Gray, Nathanael S

“…Cyclin-dependent kinase 7 (CDK7) regulates both cell cycle and transcription, but its precise role remains elusive. We previously described THZ1, a CDK7…”
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Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor by Lim, Sang Min, Westover, Kenneth D., Ficarro, Scott B., Harrison, Rane A., Choi, Hwan Geun, Pacold, Michael E., Carrasco, Martin, Hunter, John, Kim, Nam Doo, Xie, Ting, Sim, Taebo, Jänne, Pasi A., Meyerson, Matthew, Marto, Jarrod A., Engen, John R., Gray, Nathanael S.

“…We report the synthesis of a GDP analogue, SML‐8‐73‐1, and a prodrug derivative, SML‐10‐70‐1, which are selective, direct‐acting covalent inhibitors of the…”
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Case Report: Resolution of radiation pneumonitis with androgens and growth hormone by Yen, Allen, Westover, Kenneth D.

“…Radiation pneumonitis (RP) occurs in some patients treated with thoracic radiation therapy. RP often self-resolves, but when severe it is most commonly treated…”
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Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C by Zeng, Mei, Lu, Jia, Li, Lianbo, Feru, Frederic, Quan, Chunshan, Gero, Thomas W, Ficarro, Scott B, Xiong, Yuan, Ambrogio, Chiara, Paranal, Raymond M, Catalano, Marco, Shao, Jay, Wong, Kwok-Kin, Marto, Jarrod A, Fischer, Eric S, Jänne, Pasi A, Scott, David A, Westover, Kenneth D, Gray, Nathanael S

“…Targeted covalent small molecules have shown promise for cancers driven by KRAS G12C. Allosteric compounds that access an inducible pocket formed by movement…”
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Shell feature: a new radiomics descriptor for predicting distant failure after radiotherapy in non-small cell lung cancer and cervix cancer by Hao, Hongxia, Zhou, Zhiguo, Li, Shulong, Maquilan, Genevieve, Folkert, Michael R, Iyengar, Puneeth, Westover, Kenneth D, Albuquerque, Kevin, Liu, Fang, Choy, Hak, Timmerman, Robert, Yang, Lin, Wang, Jing

“…Distant failure is the main cause of human cancer-related mortalities. To develop a model for predicting distant failure in non-small cell lung cancer (NSCLC)…”
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Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis by Wang, Dong, Bushnell, David A., Westover, Kenneth D., Kaplan, Craig D., Kornberg, Roger D.

“…New structures of RNA polymerase II (pol II) transcribing complexes reveal a likely key to transcription. The trigger loop swings beneath a correct nucleoside…”
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Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution by Wang, Dong, Bushnell, David A, Huang, Xuhui, Westover, Kenneth D, Levitt, Michael, Kornberg, Roger D

“…Transcribing RNA polymerases oscillate between three stable states, two of which, pre- and posttranslocated, were previously subjected to x-ray crystal…”
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Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling by Hwang, So-Young, Deng, Xianming, Byun, Sanguine, Lee, Chan, Lee, Seung-Joo, Suh, Hyunsuk, Zhang, Jianming, Kang, Qiaofeng, Zhang, Ting, Westover, Kenneth D., Mandinova, Anna, Lee, Sam W.

“…The Wnt/β-catenin signaling pathway plays a major role in tissue homeostasis, and its dysregulation can lead to various human diseases. Aberrant activation of…”
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GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing by Yu, Dong-Min, Zhao, Jiawei, Lee, Eunice E, Kim, Dohun, Mahapatra, Ruchika, Rose, Elysha K, Zhou, Zhiwei, Hosler, Calvin, El Kurdi, Abdullah, Choe, Jun-Yong, Abel, E Dale, Hoxhaj, Gerta, Westover, Kenneth D, Cho, Raymond J, Cheng, Jeffrey B, Wang, Richard C

“…The facilitative GLUT1 and GLUT3 hexose transporters are expressed abundantly in macrophages, but whether they have distinct functions remains unclear. We…”
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Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR by QINGSONG LIU, CHUNXIAO XU, ERCAN, Dalia, NIEPEL, Mario, THOREEN, Carson C, KANG, Seong A, PATRICELLI, Matthew P, YUCHUAN WANG, TUPPER, Tanya, ALTABEF, Abigail, KAWAMURA, Hidemasa, HELD, Kathryn D, KIRUBAKARAN, Sivapriya, CHOU, Danny M, ELLEDGE, Stephen J, JANNE, Pasi A, WONG, Kwok-Kin, SABATINI, David M, GRAY, Nathanael S, XIN ZHANG, HUR, Wooyoung, YAN LIU, KWIATKOWSKI, Nicholas P, JINHUA WANG, WESTOVER, Kenneth D, PENG GAO

“…mTOR is a highly conserved serine/threonine protein kinase that serves as a central regulator of cell growth, survival, and autophagy. Deregulation of the…”
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Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability by Kopra, Kari, Valtonen, Salla, Mahran, Randa, Kapp, Jonas N, Hassan, Nazia, Gillette, William, Dennis, Bryce, Li, Lianbo, Westover, Kenneth D, Plückthun, Andreas, Härmä, Harri

“…Thermal unfolding methods are commonly used as a predictive technique by tracking the protein's physical properties. Inherent protein thermal stability and…”
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Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT by Li, Qing, Zhou, Zhi-Wei, Duan, Wei, Qian, Cheng-Yuan, Wang, Shu-Nan, Deng, Meng-Sheng, Zi, Dan, Wang, Jian-Min, Mao, Cheng-Yi, Song, Guanbin, Wang, Dong, Westover, Kenneth D, Xu, Cheng-Xiong

“…Metastasis is a major challenge in cervical cancer treatment. Previous studies have shown that the dual functional protein apurinic/apyrimidinic endonuclease 1…”
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Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms by Bushnell, David A., Westover, Kenneth D., Davis, Ralph E., Kornberg, Roger D.

“…The structure of the general transcription factor IIB (TFIIB) in a complex with RNA polymerase II reveals three features crucial for transcription initiation:…”
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