Search Results - "Weston, Hazel"

Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution by Hagmann, William K, Kissinger, Amy L, Shah, Shrenik K, Finke, Paul E, Dorn, Conrad P, Brause, Karen A, Ashe, Bonnie M, Weston, Hazel, Maycock, Alan L

“…The effect of changing the C-4 substituent of 3,3-diethyl-1-[(benzylamino)carbonyl]-2-azetidinone on inhibition of HLE and in a model of HLE-induced lung…”
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Orally Active .beta.-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones by Finke, Paul E, Shah, Shrenik K, Fletcher, Daniel S, Ashe, Bonnie M, Brause, Karen A, Chandler, Gilbert O, Dellea, Pam S, Hand, Karen M, Maycock, Alan L

“…The stereospecific synthesis of several 4-[(4-carboxyphenyl)oxy]- 3,3-dialkyl-1-[[(1-phenylalkyl)-amino]carbonyl]azetidin-2-on es 3 is described in which the…”
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Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones by Shah, Shrenik K, Dorn, Conrad P, Finke, Paul E, Hale, Jeffrey J, Hagmann, William K, Brause, Karen A, Chandler, Gilbert O, Kissinger, Amy L, Ashe, Bonnie M

“…A thorough analysis of the mechanism of inhibition of human leukocyte elastase (HLE) by a monocyclic beta-lactam and the mechanism of beta-lactam hydrolysis…”
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Chemical, Biochemical, Pharmacokinetic, and Biological Properties of L-680, 833: A Potent, Orally Active Monocyclic β-Lactam Inhibitor of Human Polymorphonuclear Leukocyte Elastase by Doherty, James B., Shah, Shrenik K., Finke, Paul E., Dorn, Conrad P., Hagmann, William K., Hale, Jeffrey J., Kissinger, Amy L., Thompson, Kevan R., Brause, karen, Chandler, Gilbert O., Knight, Wilson B., Maycock, Alan L., Ashe, Bonnie M., Weston, Hazel, Gale, Paul, Mumford, Richard A., Andersen, O. Frederick, Williams, Hollis R., Nolan, Thomas E., Frankenfield, Dale L., Underwood, Dennis, Vyas, Kamlesh P., Kari, Prasad H., Dahlgren, Mary E., Mao, Jennifer, Fletcher, Daniel S., Pa. S. Dellea, Hand, Karen M., Osinga, Donald G., Peterson, Laurence B., Williams, Dorsey T., Metzger, Joseph M., Bonney, Robert J., Humes, John L., Pacholok, Steven P., Hanlon, William A., Opas, Evan, Stolk, Jan, Davies, Philip

“…A series of potent and highly selective time-dependent monocyclic β-lactam inhibitors of human polymorphonuclear leukocyte elastase (PMNE, EC 3.4.21.37) is…”
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Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol by Finke, Paul E, Shah, Shrenik K, Ashe, Bonnie M, Ball, Richard G, Blacklock, Thomas J, Bonney, Robert J, Brause, Karen A, Chandler, Gilbert O, Cotton, Meredith

“…Human leukocyte elastase (HLE) is a serine protease which has been implicated as a causative agent in several pulmonary diseases. The continued modification of…”
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Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters by Doherty, James B, Ashe, Bonnie M, Barker, Peter L, Blacklock, Thomas J, Butcher, John W, Chandler, Gilbert O, Dahlgren, M. Ellen, Davies, Philip, Dorn, Conrad P

“…Time-dependent inhibitors of the enzyme human leukocyte elastase have been developed based on the cephem nucleus. A series of cephalosporin tert-butyl esters…”
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Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides by Finke, Paul E, Ashe, Bonnie M, Knight, Wilson B, Maycock, Alan L, Navia, Manuel A, Shah, Shrenik K, Thompson, Kevan R, Underwood, Dennis J, Weston, Hazel

“…A variety of 7 alpha-methoxycephalosporin ester and amide sulfones were prepared and tested to determine the structure-activity relations for inhibition of…”
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Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins by Shah, Shrenik K, Brause, Karen A, Chandler, Gilbert O, Finke, Paul E, Ashe, Bonnie M, Weston, Hazel, Knight, Wilson B, Maycock, Alan L, Doherty, James B

“…Several 3'-substituted cephalosporin sulfones were synthesized from 3-(hydroxymethyl)cephalosporin, which was prepared by Ti(OiPr)4 hydrolysis of the…”
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Immunity against infection with Trypanosoma cruzi in mice correlates with presence of antibodies against three trypomastigote polypeptides by ZWEERINK, H. J, WESTON, H. D, ANDERSEN, O. F, GARBER, S. S, HAYES, E. C

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