Search Results - "Westley, Bruce"

TFF3 is a valuable predictive biomarker of endocrine response in metastatic breast cancer by May, Felicity E B, Westley, Bruce R

“…The stratification of breast cancer patients for endocrine therapies by oestrogen or progesterone receptor expression is effective but imperfect. The present…”
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Insulin-like Growth Factor-Dependent Proliferation and Survival of Triple-Negative Breast Cancer Cells: Implications for Therapy by Davison, Zoë, de Blacquière, Gail E, Westley, Bruce R, May, Felicity E.B

“…Abstract Triple-negative breast cancers have a poor prognosis and are not amenable to endocrine- or HER2-targeted therapies. The prevailing view is that…”
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TFF3 Is a Normal Breast Epithelial Protein and Is Associated with Differentiated Phenotype in Early Breast Cancer but Predisposes to Invasion and Metastasis in Advanced Disease by Ahmed, Ahmed R.H, Griffiths, Andrew B, Tilby, Michael T, Westley, Bruce R, May, Felicity E.B

“…The trefoil protein TFF3 stimulates invasion and angiogenesis in vitro . To determine whether it has a role in breast tumor metastasis and angiogenesis, its…”
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Trefoil factor 1 stimulates both pancreatic cancer and stellate cells and increases metastasis by Arumugam, Thiruvengadam, Brandt, Will, Ramachandran, Vijaya, Moore, Tood T, Wang, Huamin, May, Felicity E, Westley, Bruce R, Hwang, Rosa F, Logsdon, Craig D

“…Trefoil factor 1 (TFF1) is a stable secretory protein expressed widely in the gastrointestinal mucosa that is also expressed in pancreatic ductal…”
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Decreased Expression of Gastrokine 1 and the Trefoil Factor Interacting Protein TFIZ1/GKN2 in Gastric Cancer: Influence of Tumor Histology and Relationship to Prognosis by MOSS, Steven F, LEE, Jin-Woo, RESNICK, Murray B, SABO, Edmond, RUBIN, Anna K, ROMMEL, John, WESTLEY, Bruce R, MAY, Felicity E. B, GAO, John, MEITNER, Patricia A, TAVARES, Rose

“…Purpose: Transcriptional profiling showed decreased expression of gastrokine 1 (GKN1) and the related trefoil factor interacting protein (TFIZ1/GKN2) in…”
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Helicobacter pylori Lipopolysaccharide Interacts With TFF1 in a pH-Dependent Manner by Reeves, Emer P, Ali, Tehmeena, Leonard, Paul, Hearty, Stephen, O'Kennedy, Richard, May, Felicity E.B, Westley, Bruce R, Josenhans, Christine, Rust, Melanie, Suerbaum, Sebastian, Smith, Angeline, Drumm, Brendan, Clyne, Marguerite

“…Background & Aims Little is known about how bacteria establish chronic infections of mucosal surfaces. Helicobacter pylori ( H pylori ), a chronic pathogen…”
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Interaction between TFF1, a Gastric Tumor Suppressor Trefoil Protein, and TFIZ1, a Brichos Domain-Containing Protein with Homology to SP-C by Westley, Bruce R, Griffin, S. Michael, May, Felicity E. B

“…TFF1 is a gastric tumor suppressor that protects gastric epithelial cells from damage but can promote invasive properties of tumor cells. Antibodies were…”
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The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer by May, Felicity E.B., Griffin, S. Michael, Westley, Bruce R.

“…The gastric tumour suppressor trefoil protein TFF1 is present as a covalently bound heterodimer with a previously uncharacterised protein, TFIZ1, in normal…”
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The estrogen‐regulated protein, TFF1, stimulates migration of human breast cancer cells by Prest, Sara J., May, Felicity E. B., Westley, Bruce R.

“…ABSTRACT The human trefoil protein TFF1 is a small cysteine‐rich secreted protein that is frequently expressed in breast tumors under the control of estrogen…”
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Helicobacter pylori Interacts with the Human Single-Domain Trefoil Protein TFF1 by Clyne, Marguerite, Dillon, Paul, Daly, Stephen, O'Kennedy, Richard, Felicity E. B. May, Westley, Bruce R., Drumm, Brendan, Falkow, Stanley

“…Why Helicobacter pylori colonizes only gastric tissue is unknown. It is found on gastric mucus-secreting cells and in the overlying gastric mucus but not deep…”
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Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase‐2 and EGF receptor signaling by Rodrigues, Sylvie, Aken, Elisabeth, Bocxlaer, Saskia, Attoub, Samir, Nguyen, Quang‐Dé, Bruyneel, Erik, Westley, Bruce R., May, Felicity E. B., Thim, Lars, Mareel, Marc, Gespach, Christian, Emami, Shahin

“…ABSTRACT We previously established that the trefoil peptides (TFFs) pS2, spasmolytic polypeptide, and intestinal trefoil factor are involved in cellular…”
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Increased expression of both insulin receptor substrates 1 and 2 confers increased sensitivity to IGF-1 stimulated cell migration by de Blaquière, Gail E, May, Felicity E B, Westley, Bruce R

“…Insulin-like growth factors (IGFs) are thought to promote tumour progression and metastasis in part by stimulating cell migration. Insulin receptor substrate-1…”
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Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor by Chutipongtanate, Somchai, Nakagawa, Yasushi, Sritippayawan, Suchai, Pittayamateekul, Jeeraporn, Parichatikanond, Paisal, Westley, Bruce R, May, Felicity E B, Malasit, Prida, Thongboonkerd, Visith

“…Previous research on proteins that inhibit kidney stone formation has identified a relatively small number of well-characterized inhibitors. Identification of…”
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The estrogen‐regulated protein, TFF1, stimulates migration of human breast cancer cells by Prest, Sara J., May, Felicity E. B., Westley, Bruce R.

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Estrogen regulates vesicle trafficking gene expression in EFF-3, EFM-19 and MCF-7 breast cancer cells by Wright, Paul K, May, Felicity Eb, Darby, Steve, Saif, Rehan, Lennard, Tom Wj, Westley, Bruce R

“…Estrogens are critical mediators of breast tumorigenesis. This occurs via the action of estrogens on the estrogen receptor (ER), which regulates the…”
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Increased TFF1 trefoil protein expression in Opisthorchis viverrini-associated cholangiocarcinoma is important for invasive promotion by Thuwajit, Peti, Chawengrattanachot, Watinee, Thuwajit, Chanitra, Sripa, Banchob, May, Felicity E. B., Westley, Bruce R., Tepsiri, Nisana N., Paupairoj, Anucha, Chau-in, Siri

“…Aims:  Cholangiocarcinoma (CCA) is a poor prognosis cancer that presents with metastatic disease. This cancer expresses MUC5AC, a mucin which normally…”
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Induction of scattering and cellular invasion by trefoil peptides in src‐ and RhoA‐transformed kidney and colonic epithelial cells by EMAMI, SHAHIN, FLOCH, NATHALIE LE, BRUYNEEL, ERIK, THIM, LARS, MAY, FELICITY, WESTLEY, BRUCE, RIO, MARIE‐CHRISTINE, MAREEL, MARC, GESPACH, CHRISTIAN

“…ABSTRACT Trefoil factors (TFFs) are protease‐resistant peptides that promote epithelial cell migration and mucosal restitution during inflammatory conditions…”
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Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells by RODRIGUES, Sylvie, ATTOUB, Samir, GESPACH, Christian, NGUYEN, Quang-Dé, BRUYNEEL, Erik, RODRIGUE, Christelle M, WESTLEY, Bruce R, MAY, Felicity E. B, THIM, Lars, MAREEL, Marc, EMAMI, Shahin

“…Trefoil peptides (TFFs) are now considered as scatter factors, proinvasive and angiogenic agents acting through cyclooxygenase-2 (COX-2)- and thromboxane A2…”
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Solution Structure of the Disulfide-Linked Dimer of Human Intestinal Trefoil Factor (TFF3):  The Intermolecular Orientation and Interactions Are Markedly Different from Those of Other Dimeric Trefoil Proteins by Muskett, Frederick W, May, Felicity E. B, Westley, Bruce R, Feeney, James

“…The trefoil protein TFF3 forms a homodimer (via a disulfide linkage) that is thought to have increased biological activity over the monomer. The solution…”
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Activation of cellular invasion by trefoil peptides and src is mediated by cyclooxygenase‐ and thromboxane A2 receptor‐dependent signaling pathways by Rodrigues, Sylvie, Nguyen, Quang-Dé, Faivre, Sandrine, Bruyneel, Erik, Thim, Lars, Westley, Bruce, May, Felicity, Flatau, Gilles, Mareel, Marc, Gespach, Christian, Emami, Shahin

“…ABSTRACT We have investigated the possible functional relationships between cellular invasion pathways induced by trefoil factors (TFFs), src, and the…”
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