Search Results - "Westin Eriksson, Annika"

Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases by Perry, Matthew W. D, Abdulai, Raolat, Mogemark, Mickael, Petersen, Jens, Thomas, Matthew J, Valastro, Barbara, Westin Eriksson, Annika

“…Phosphoinositol 3-kinases (PI3Ks) γ and δ are key enzymes in hematopoietic cells and have been seen as high-value targets for the treatment of diseases with…”
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Discovery and Early Clinical Development of an Inhibitor of 5‑Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease by Pettersen, Daniel, Broddefalk, Johan, Emtenäs, Hans, Hayes, Martin A, Lemurell, Malin, Swanson, Marianne, Ulander, Johan, Whatling, Carl, Amilon, Carl, Ericsson, Hans, Westin Eriksson, Annika, Granberg, Kenneth, Plowright, Alleyn T, Shamovsky, Igor, Dellsèn, Anita, Sundqvist, Monica, Någård, Mats, Lindstedt, Eva-Lotte

“…5-Lipoxygenase activating protein (FLAP) inhibitors attenuate 5-lipoxygenase pathway activity and reduce the production of proinflammatory and vasoactive…”
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Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors by Pemberton, Nils, Mogemark, Mickael, Arlbrandt, Susanne, Bold, Peter, Cox, Rhona J, Gardelli, Cristina, Holden, Neil S, Karabelas, Kostas, Karlsson, Johan, Lever, Sarah, Li, Xueshan, Lindmark, Helena, Norberg, Monica, Perry, Matthew W. D, Petersen, Jens, Rodrigo Blomqvist, Sandra, Thomas, Matthew, Tyrchan, Christian, Westin Eriksson, Annika, Zlatoidsky, Pavol, Öster, Linda

“…In this paper, we describe the discovery and optimization of a new chemotype of isoform selective PI3Kγ inhibitors. Starting from an HTS hit, potency and…”
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Novel Chemical Series of 5‑Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease by Lemurell, Malin, Ulander, Johan, Emtenäs, Hans, Winiwarter, Susanne, Broddefalk, Johan, Swanson, Marianne, Hayes, Martin A, Prieto Garcia, Luna, Westin Eriksson, Annika, Meuller, Johan, Cassel, Johan, Saarinen, Gabrielle, Yuan, Zhong-Qing, Löfberg, Christian, Karlsson, Staffan, Sundqvist, Monica, Whatling, Carl

“…5-Lipoxygenase (5-LO)-activating protein (FLAP) inhibitors have proven to attenuate 5-LO pathway activity and leukotriene production in human clinical trials…”
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Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma by Perry, Matthew W. D, Björhall, Karin, Bold, Peter, Brűlls, Mikael, Börjesson, Ulf, Carlsson, Johan, Chang, Hui-Fang Amy, Chen, Yunhua, Eriksson, Anders, Fihn, Britt-Marie, Fransson, Rebecca, Fredlund, Linda, Ge, Hongbin, Huang, Haijuan, Karabelas, Kostas, Lamm Bergström, Eva, Lever, Sarah, Lindmark, Helena, Mogemark, Mickael, Nikitidis, Antonios, Palmgren, Anna-Pia, Pemberton, Nils, Petersen, Jens, Rodrigo Blomqvist, Mio, Smith, Reed W, Thomas, Matthew J, Ullah, Victoria, Tyrchan, Christian, Wennberg, Tiiu, Westin Eriksson, Annika, Yang, Wenzhen, Zhao, Shuchun, Öster, Linda

“…Starting from our previously described PI3Kγ inhibitors, we describe the exploration of structure–activity relationships that led to the discovery of highly…”
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Are GPR81 agonists associated with cardiovascular effects? by Benjamin, Amanda, Collins, Teresa, Fjellström, Ola, Lengel, David, Thalén, Pia, Wahlund, Göran, Wallenius, Kristina, Eriksson, Annika Westin

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Effect of broad-spectrum matrix metalloproteinase inhibition on atherosclerotic plaque stability by JOHNSON, Jason L, FRITSCHE-DANIELSON, Regina, BEHRENDT, Margareta, WESTIN-ERIKSSON, Annika, WENNBO, Hakan, HERSLOF, Margareta, ELEBRING, Marie, GEORGE, Sarah J, MCPHEAT, William L, JACKSON, Christopher L

“…Matrix metalloproteinases (MMPs) form a large family of enzymes that collectively can degrade all components of the extracellular matrix, and there is…”
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Site-specific antiatherogenic effect of N,N'-diacetyl-L-cystine in apoE;LDLr(−/−) mice by Westin Eriksson, Annika, Pettersson, Knut

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Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice by Witting, Paul K., Pettersson, Knut, Östlund-Lindqvist, Anne-Margret, Westerlund, Christer, Eriksson, Annika Westin, Stocker, Roland

“…Antioxidants can inhibit atherosclerosis in animals, though it is not clear whether this is due to the inhibition of aortic lipoprotein lipid (per)oxidation…”
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1.P.91 Atherosclerosis in the aorta of combined apoE/LDLr deficient mice: Interaction between lesion site and gender by Eriksson, Annika Westin, Pettersson, Knut

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1.P.115 Effects of probucol on aortic and coronary atherosclerosis in young, adolescent and old WHHL rabbits by Wågberg, Maria, Eriksson, Annika Westin, Pettersson, Knut

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