Search Results - "Westfield, Lisa"

Allosteric activation of ADAMTS13 by von Willebrand factor by Muia, Joshua, Zhu, Jian, Gupta, Garima, Haberichter, Sandra L., Friedman, Kenneth D., Feys, Hendrik B., Deforche, Louis, Vanhoorelbeke, Karen, Westfield, Lisa A., Roth, Robyn, Tolia, Niraj Harish, Heuser, John E., Sadler, J. Evan

“…Significance The blood protein von Willebrand factor (VWF) is required for platelets to stop bleeding at sites of injury, and the metalloprotease ADAMTS13…”
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Adjuvant low-dose rituximab and plasma exchange for acquired TTP by Zwicker, Jeffrey I., Muia, Joshua, Dolatshahi, Leili, Westfield, Lisa A., Nieters, Patricia, Rodrigues, Anita, Hamdan, Ayad, Antun, Ana G., Metjian, Ara, Sadler, J. Evan

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Exploring the “minimal” structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering by Zhu, Jian, Muia, Joshua, Gupta, Garima, Westfield, Lisa A., Vanhoorelbeke, Karen, Tolia, Niraj H., Sadler, J. Evan

“…Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains, followed by…”
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Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation by Muia, Joshua, Zhu, Jian, Greco, Suellen C., Vanhoorelbeke, Karen, Gupta, Garima, Westfield, Lisa A., Sadler, J. Evan

“…The metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats member 13) prevents microvascular thrombosis by cleaving von…”
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Unfolding the A2 Domain of Von Willebrand Factor with the Optical Trap by Ying, Junyi, Ling, Yingchen, Westfield, Lisa A., Sadler, J. Evan, Shao, Jin-Yu

“…Von Willebrand factor (VWF) is a multimeric plasma glycoprotein involved in both hemostasis and thrombosis. VWF conformational changes, especially unfolding of…”
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Rearranging Exosites in Noncatalytic Domains Can Redirect the Substrate Specificity of ADAMTS Proteases by Gao, Weiqiang, Zhu, Jian, Westfield, Lisa A., Tuley, Elodee A., Anderson, Patricia J., Sadler, J. Evan

“…ADAMTS proteases typically employ some combination of ancillary C-terminal disintegrin-like, thrombospondin-1, cysteine-rich, and spacer domains to bind…”
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Phylogenetic and Functional Analysis of Histidine Residues Essential for pH-dependent Multimerization of von Willebrand Factor by Dang, Luke T., Purvis, Angie R., Huang, Ren-Huai, Westfield, Lisa A., Sadler, J. Evan

“…von Willebrand factor (VWF) is a multimeric plasma protein that mediates platelet adhesion to sites of vascular injury. The hemostatic function of VWF depends…”
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Incomplete Embryonic Lethality and Fatal Neonatal Hemorrhage Caused by Prothrombin Deficiency in Mice by Xue, Jiachun, Wu, Qingyu, Westfield, Lisa A., Tuley, Elodee A., Lu, Deshun, Zhang, Qing, Shim, Kyuhwan, Zheng, Xinglong, Sadler, J. Evan

“…Deficiency of blood coagulation factor V or tissue factor causes the death of mouse embryos by 10.5 days of gestation, suggesting that part of the blood…”
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A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury by Shim, Kyuhwan, Zhu, Hongfa, Westfield, Lisa A., Sadler, J. Evan

“…Mutations in human prothrombin that generate a stable form of meizothrombin or meizothrombin(desF1) cause dysprothrombinemia in both the homozygous and…”
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Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction by Mancuso, David J, Tuley, Elodee A, Westfield, Lisa A, Lester-Mancuso, Teresa L, Le Beau, Michelle M, Sorace, James M, Sadler, J. Evan

“…Structural analysis of the von Willebrand factor gene located on chromosome 12 is complicated by the presence of a partial unprocessed pseudogene on chromosome…”
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Efficacy of Adjuvant Low Dose Rituximab and Plasma Exchange for Acquired TTP with Severe ADAMTS13 Deficiency — Results of the ART Study by Sadler, J. Evan, Muia, Joshua, Dolatshahi, Leili, Westfield, Lisa A., Nieters, Patricia, Rodrigues, Anita, Antun, Ana G., Metjian, Ara, Zwicker, Jeffrey I.

“…▪ Introduction:Acquired thrombotic thrombocytopenic purpura (TTP) is caused by autoantibodies against ADAMTS13 that prevent the cleavage of von Willebrand…”
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Phylogenetic Analysis Identifies a Subset of ADAMTS13 Domains That Are Highly Conserved and Essential for Allosteric Regulation by Muia, Joshua, Zhu, Jian, Greco, Suellen, Vanhoorelbeke, Karen, Deforche, Louis, Westfield, Lisa, Tyagi, Garima, Sadler, J. Evan

“…Introduction: Human ADAMTS13 has metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C) and spacer (S) domains (proximal domains),…”
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A Folded ADAMTS13 Conformation Identified By Small-Angle X-Ray Scattering Can Account for Allosteric Regulation By Distal Thrombospondin-1 and CUB Domains by Zhu, Jian, Muia, Joshua, Tolia, Niraj H., Westfield, Lisa A, Sadler, J. Evan

“…Introduction: ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C) and spacer (S) domains,…”
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Distinct Functions of pH-Sensing Histidine Residues in the Multimer Assembly and Storage of Von Willebrand Factor in Weibel-Palade Bodies by Huang, Jing, Westfield, Lisa A, Sadler, J. Evan

“…Abstract 3311 The hemostatic function of von Willebrand factor (VWF) depends on the formation of disulfide-linked multimers. We have previously shown that…”
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Molecular mechanism and classification of von Willebrand disease by Sadler, J E, Matsushita, T, Dong, Z, Tuley, E A, Westfield, L A

“…The characterization of mutations in von Willebrand disease provides useful insight into the synthesis, structure, and function of von Willebrand factor. This…”
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Severe Type III von Willebrand's Disease Caused by Deletion of Exon 42 of the von Willebrand Factor Gene: Family Studies That Identify Carriers of the Condition and a Compound Heterozygous Individual by Peake, Ian R., Liddell, Malcolm B., Moodie, Patricia, Standen, Graham, Mancuso, David J., Tuley, Elodee A., Westfield, Lisa A., Sorace, James M., Sadler, J. Evan, Verweij, Cornelis L., Bloom, Arthur L.

“…Southern blotting was performed with cDNA probes for the human von Willebrand factor (vWF) gene on six patients with severe type III von Willebrand's disease…”
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Molecular biology of von Willebrand factor by Sadler, J E, Mancuso, D J, Randi, A M, Tuley, E A, Westfield, L A

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