Search Results - "Westfall, Thomas C."

Inactivation of Catecholamines by Superoxide Gives New Insights on the Pathogenesis of Septic Shock by Macarthur, Heather, Westfall, Thomas C., Riley, Dennis P., Misko, Thomas P., Salvemini, Daniela

“…A major feature of septic shock is the development of a vascular crisis characterized by nonresponsiveness to sympathetic vasoconstrictor agents and the…”
Get full text

Nerve stimulation induced overflow of neuropeptide Y and modulation by angiotensin II in spontaneously hypertensive rats by Byku, Mirnela, Macarthur, Heather, Westfall, Thomas C

“…The sympathetic nervous system and renin-angiotensin system are both thought to contribute to the development and maintenance of hypertension in experimental…”
Get more information

Cytotoxicity of dopaminochrome in the mesencephalic cell line, MN9D, is dependent upon oxidative stress by Linsenbardt, Andrew J., Wilken, Gerald H., Westfall, Thomas C., Macarthur, Heather

“…Parkinson disease is a specific form of neurodegeneration characterized by a loss of nigra-striatal dopaminergic neurons in the midbrain of humans. The disease…”
Get full text

Neuropeptide Y Induced Attenuation of Catecholamine Synthesis in the Rat Mesenteric Arterial Bed by Westfall, Thomas C, Naes, Linda, Gardner, Alice, Yang, Chun-Lian

“…The effect of neuropeptide Y (NPY) on the basal and nerve stimulation-induced increase in norepinephrine synthesis was studied in the isolated and perfused…”
Get full text

Inhibitory effects of angiotensin-(1-7) on the nerve stimulation-induced release of norepinephrine and neuropeptide Y from the mesenteric arterial bed by Byku, Mirnela, Macarthur, Heather, Westfall, Thomas C

“…Neuropeptide Y (NPY) is a cotransmitter with norepinephrine (NE) and ATP in sympathetic nerves. There is evidence for increased activity of the sympathetic…”
Get more information

Endothelin-induced modulation of neuropeptide Y and norepinephrine release from the rat mesenteric bed by Hoang, Dan, Macarthur, Heather, Gardner, Alice, Westfall, Thomas C

“…The effect of three endothelin (ET) agonists [ET-1, ET-3, and sarafotoxin (STX6C)] on the nerve stimulation-induced release of norepinephrine (NE) and…”
Get more information

Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus by Gamber, Kevin M., Macarthur, Heather, Westfall, Thomas C.

“…Little is known about the mechanism of action behind the orexigenic activity of cannabinoids. Neuropeptide Y (NPY) is one of the most potent orexigenic factors…”
Get full text

Oxidative stress attenuates NO-induced modulation of sympathetic neurotransmission in the mesenteric arterial bed of spontaneously hypertensive rats by Macarthur, Heather, Westfall, Thomas C, Wilken, Gerald H

“…Current evidence suggests that hyperactivity of the sympathetic nervous system and endothelial dysfunction are important factors in the development and…”
Get more information

Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors by Adewale, Adepero Shola, Macarthur, Heather, Westfall, Thomas C

“…The purpose of the present study was to determine whether or not activation of neuropeptide Y (NPY) receptors resulted in an enhancement or attenuation of the…”
Get full text

Interactions of neuropeptide y, catecholamines, and angiotensin at the vascular neuroeffector junction by Westfall, Thomas C, Macarthur, Heather, Byku, Mirnela, Yang, Chun-Lian, Murray, Jessica

“…Work from our laboratory has established that angiotensin II (Ang II) produces a greater enhancement of the nerve stimulation (NS)-induced release (overflow)…”
Get more information

Nitric oxide decreases the biological activity of norepinephrine resulting in altered vascular tone in the rat mesenteric arterial bed by Kolo, Lacy L, Westfall, Thomas C, Macarthur, Heather

“…Nitric oxide (NO) reacts with catecholamines resulting in their deactivation. In this study, we demonstrated that coincubation of NO donors with sympathetic…”
Get more information

Mechanism of dopamine mediated inhibition of neuropeptide Y release from pheochromocytoma cells (PC12 cells) by Cao, Guihua, Gardner, Alice, Westfall, Thomas C.

“…In rat pheochromocytoma (PC12) cells the dopamine D2 receptor agonists apomorphine (APO) and n-propylnorapomorphine (NPA) produced a concentration dependent…”
Get full text

Pharmacological and physiological science is the essence of life itself by Westfall, Thomas C

Get full text

Use of human simulators to better teach the physiology and pharmacology of autonomic and cardiovascular drugs by Westfall, Thomas C

Get full text

Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: Correlation with preserved circulating catecholamines by Macarthur, Heather, Couri, Daniel M, Wilken, Gerald H, Westfall, Thomas C, Lechner, Andrew J, Matuschak, George M, Chen, Zhoumou, Salvemini, Daniela

“…OBJECTIVESWe have shown previously that inactivation of catecholamines by superoxide anions contributes to the loss of vascular reactivity to norepinephrine…”
Get full text

The separation and quantification of aminochromes using high-pressure liquid chromatography with electrochemical detection by Ochs, Scott D., Westfall, Thomas C., Macarthur, Heather

“…There is increasing evidence that oxidative stress plays an important role in the pathogenesis of many neurodegenerative diseases including Parkinson's disease…”
Get full text

Modulation of neurotransmitter release by NO is altered in mesenteric arterial bed of spontaneously hypertensive rats by Kolo, Lacy L, Westfall, Thomas C, Macarthur, Heather

“…Nitric oxide (NO) reacts with catecholamines resulting in their deactivation. In the present study with the use of the perfused mesenteric arterial bed as a…”
Get more information

Neuropeptide-Y-ATP interactions at the vascular sympathetic neuroeffector junction by Westfall, T C, Yang, C L, Curfman-Falvey, M

“…Neuropeptide Y (NPY) and ATP are considered cotransmitters with norepinephrine (NE) in sympathetic neurons innervating some blood vessels, including those of…”
Get more information

Neuropeptide Y induced modulation of dopamine synthesis in the striatum by Adewale, Adepero Shola, Macarthur, Heather, Westfall, Thomas C.

“…The purpose of the present study was to determine whether the activation of NPY receptors alters catecholamines (CA) synthesis in the central nervous system…”
Get full text

Autoreceptor-induced inhibition of neuropeptide Y release from PC-12 cells is mediated by Y2 receptors by Chen, X, DiMaggio, D A, Han, S P, Westfall, T C

“…Pheochromocytoma (PC)-12 cells express Y1, Y2, and Y3 neuropeptide Y (NPY) receptors when differentiated with nerve growth factor (NGF). The present work…”
Get full text