Prognosis of Solitary Fibrous Tumors: A Multicenter Study

Background Solitary fibrous tumors (SFTs) are rare mesenchymal tumors, and data regarding outcome and prognostic factors are scarce. We report the outcome and analysis of prognostic factors of a retrospective multicenter cohort study for patients treated for SFTs. Methods Retrospective analysis was...

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Bibliographic Details
Published in:	Annals of surgical oncology Vol. 20; no. 13; pp. 4090 - 4095
Main Authors:	van Houdt, Winan J., Westerveld, Charlotte M. A., Vrijenhoek, Joyce E. P., van Gorp, Joost, van Coevorden, Frits, Verhoef, Cornelis, van Dalen, Thijs
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-12-2013 Springer Nature B.V
Subjects:	Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Bone and Soft Tissue Sarcomas Female Follow-Up Studies Humans Immunoenzyme Techniques Male Medicine Medicine & Public Health Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Neoplasm Staging Oncology Prognosis Retrospective Studies Soft Tissue Neoplasms - mortality Soft Tissue Neoplasms - pathology Soft Tissue Neoplasms - surgery Solitary Fibrous Tumors - mortality Solitary Fibrous Tumors - pathology Solitary Fibrous Tumors - surgery Surgery Surgical Oncology Survival Rate Young Adult Local Recurrence Solitary Fibrous Tumor Epithelial Membrane Antigen Smooth Muscle Actin Metastasis Formation
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Summary:	Background Solitary fibrous tumors (SFTs) are rare mesenchymal tumors, and data regarding outcome and prognostic factors are scarce. We report the outcome and analysis of prognostic factors of a retrospective multicenter cohort study for patients treated for SFTs. Methods Retrospective analysis was performed of patients treated for SFTs between 1995 and 2012. Clinical and histopathological features were analyzed for prognostic value. Endpoints were set at local recurrence, metastasis formation, or death. Survival was analyzed using Kaplan–Meier and Cox proportional hazards analyses. Results A total of 81 patients underwent surgical resection of a SFT with curative intent. During follow-up, 21 patients developed distant metastases, while 18 patients developed local recurrence. The 5-year overall survival was 84 %. The local recurrence rate and the metastasis rate at 5 years were 29 and 34 %, respectively. Of all factors analyzed, positive resection margin significantly correlated with local recurrence [hazard ratio (HR) 4.8; 95 % confidence interval (95 % CI) 1.5–14.9]. Tumor size >10 cm (HR 4.4; 95 % CI 1.7–11.5) and high mitosis rate (HR 3.3; 95 % CI 1.06–10.3) significantly correlated with higher incidence of metastases. The combination of tumors >10 cm and high mitosis rate significantly correlated with higher incidence of metastases (HR 4.8; 95 % CI 1.4–16.2) and showed a trend toward worse overall survival (HR 5.7; 95 % CI 0.95–34.7). Conclusions A substantial portion of patients with a SFT developed local recurrence or metastases. Local recurrence is significantly higher in patients with positive resection margins; metastasis frequency is significantly higher in patients with tumors >10 cm and tumors with a high mitosis rate.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1068-9265 1534-4681
DOI:	10.1245/s10434-013-3242-9