Search Results - "Westermark, Ulrica"

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells by Zirath, Hanna, Frenzel, Anna, Oliynyk, Ganna, Segerström, Lova, Westermark, Ulrica K., Larsson, Karin, Persson, Matilda Munksgaard, Hultenby, Kjell, Lehtiö, Janne, Einvik, Christer, Påhlman, Sven, Kogner, Per, Jakobsson, Per-Johan, Henriksson, Marie Arsenian

“…The MYC genes are the most frequently activated oncogenes in human tumors and are hence attractive therapeutic targets. MYCN amplification leads to poor…”
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The MYCN oncogene and differentiation in neuroblastoma by Westermark, Ulrica K, Wilhelm, Margareta, Frenzel, Anna, Henriksson, Marie Arsenian

“…Abstract Childhood neuroblastoma exhibits a heterogeneous clinical behavior ranging from low-risk tumors with the ability to spontaneously differentiate and…”
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Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase by Kass, Elizabeth M., Helgadottir, Hildur R., Chen, Chun-Chin, Barbera, Maria, Wang, Raymond, Westermark, Ulrica K., Ludwig, Thomas, Moynahan, Mary Ellen, Jasin, Maria

“…Homology-directed repair (HDR) is a critical pathway for the repair of DNA double-strand breaks (DSBs) in mammalian cells. Efficient HDR is thought to be…”
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Regulation of Nuclear Hormone Receptors by MYCN-Driven miRNAs Impacts Neural Differentiation and Survival in Neuroblastoma Patients by Ribeiro, Diogo, Klarqvist, Marcus D.R., Westermark, Ulrica K., Oliynyk, Ganna, Dzieran, Johanna, Kock, Anna, Savatier Banares, Carolina, Hertwig, Falk, Johnsen, John Inge, Fischer, Matthias, Kogner, Per, Lovén, Jakob, Arsenian Henriksson, Marie

“…MYCN amplification and MYC signaling are associated with high-risk neuroblastoma with poor prognosis. Treating these tumors remains challenging, although…”
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Hypoxia-induced down-regulation of BRCA1 expression by E2Fs by BINDRA, Ranjit S, GIBSON, Shannon L, MENG, Alice, WESTERMARK, Ulrica, JASIN, Maria, PIERCE, Andrew J, BRISTOW, Robert G, CLASSON, Marie K, GLAZER, Peter M

“…Decreased BRCA1 expression in the absence of genetic mutation is observed frequently in sporadic cancers of the breast and other sites, although little is…”
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First application of liquid-metal-jet sources for small-animal imaging: High-resolution CT and phase-contrast tumor demarcation by Larsson, Daniel H., Lundström, Ulf, Westermark, Ulrica K., Arsenian Henriksson, Marie, Burvall, Anna, Hertz, Hans M.

“…Purpose: Small-animal studies require images with high spatial resolution and high contrast due to the small scale of the structures. X-ray imaging systems for…”
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Intravenous delivery of a chemically modified sulfamidase efficiently reduces heparan sulfate storage and brain pathology in mucopolysaccharidosis IIIA mice by Gustavsson, Susanne, Ohlin Sjöström, Elisabet, Tjernberg, Agneta, Janson, Juliette, Westermark, Ulrica, Andersson, Tommy, Makower, Åsa, Arnelöf, Erik, Andersson, Gudrun, Svartengren, Jan, Ekholm, Carina, Svensson Gelius, Stefan

“…Mucopolysaccharidosis type IIIA (MPS IIIA) is a lysosomal storage disorder (LSD) characterized by severe central nervous system (CNS) degeneration. The disease…”
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Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome by Hendrikse, Natalie M., Sandegren, Anna, Andersson, Tommy, Blomqvist, Jenny, Makower, Åsa, Possner, Dominik, Su, Chao, Thalén, Niklas, Tjernberg, Agneta, Westermark, Ulrica, Rockberg, Johan, Svensson Gelius, Stefan, Syrén, Per-Olof, Nordling, Erik

“…We show the successful application of ancestral sequence reconstruction to enhance the activity of iduronate-2-sulfatase (IDS), thereby increasing its…”
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BARD1 Participates with BRCA1 in Homology-Directed Repair of Chromosome Breaks by Westermark, Ulrica K., Reyngold, Marsha, Olshen, Adam B., Baer, Richard, Jasin, Maria, Moynahan, Mary Ellen

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RAD51 can inhibit PDGF-B-induced gliomagenesis and genomic instability by Westermark, Ulrica K., Lindberg, Nanna, Roswall, Pernilla, Bråsäter, Daniel, Helgadottir, Hildur R., Hede, Sanna-Maria, Zetterberg, Anders, Jasin, Maria, Nistér, Monica, Uhrbom, Lene

“…Faithful replication and DNA repair are vital for maintenance of genome integrity. RAD51 is a central protein in homologous recombination repair and during…”
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C/EBP is an essential component of PDGFRA transcription in MG-63 cells by Afink, Gijs, Westermark, Ulrica K, Lammerts, Ellen, Nistér, Monica

“…Interleukin-1β (IL-1β) is a potent inhibitor of platelet-derived growth factor α receptor (PDGFRα) expression in MG-63 cells. Its effect is mediated at the…”
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A rapid intracellular enrichment of alkylating payload is essential for melphalan flufenamide potency and mechanism of action by Westermark, Ulrica, Diao, Yumei, Fasth, Karl-Johan, Färnegårdh, Mathias, Färnegårdh, Katarina, Hammer, Kristin, Lehmann, Fredrik, Acs, Klara, Svensson Gelius, Stefan

“…Despite decades of development of treatments and the successful application of targeted therapies for multiple myeloma, clinical challenges remain for patients…”
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MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling by Dzieran, Johanna, Garcia, Aida Rodriguez, Westermark, Ulrica Kristina, Henley, Aine Brigette, Sánchez, Elena Eyre, Träger, Catarina, Johansson, Henrik Johan, Lehtiö, Janne, Arsenian-Henriksson, Marie

“…Neuroblastoma (NB) is a remarkably heterogenic childhood tumor of the sympathetic nervous system with clinical behavior ranging from spontaneous regression to…”
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Abstract B43: MYCN-amplified neuroblastoma maintain an undifferentiated phenotype through interference with estrogen and NGF signaling by Dzieran, Johanna, Westermark, Ulrica K., Henriksson, Marie Arsenian

“…Abstract Neuroblastoma is the most common extracranial solid tumor of childhood. It is a highly heterogenic cancer of the sympathetic nervous system and…”
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Abstract B46: MYCN regulates nuclear hormone receptors and impairs differentiation and survival in neuroblastoma by Ribeiro, Diogo, Westermark, Ulrica, Klarqvist, Marcus, Lovén, Jakob, Henriksson, Marie Arsenian

“…Abstract Neuroblastoma is the most common extra-cranial solid tumor in children and arises from neural crest cells involved in the development of sympathetic…”
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First application of liquid-metal-jet sources for small-animal imaging: High-resolution CT and phase-contrast tumor demarcation: First application of liquid-metal-jet sources for small-animal imaging by Larsson, Daniel H., Lundström, Ulf, Westermark, Ulrica K., Arsenian Henriksson, Marie, Burvall, Anna, Hertz, Hans M.

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X-ray phase contrast with injected gas for tumor microangiography by Lundström, U, Westermark, U K, Larsson, D H, Burvall, A, Arsenian Henriksson, M, Hertz, H M

“…We show that the microvasculature of mouse tumors can be visualized using propagation-based phase-contrast x-ray imaging with gas as the contrast agent. The…”
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RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability by Westermark, Ulrica K, Lindberg, Nanna, Roswall, Pernilla, Bråsäter, Daniel, Helgadottir, Hildur R, Hede, Sanna, Zetterberg, Anders, Jasin, Maria, Nistér, Monica, Uhrbom, Lene

“…Faithful replication and DNA repair are vital for maintenance of genome integrity. RAD51 is a central protein in homologous recombination repair and during…”
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DNA Repair by HDR in Experimental Tumorigenesis by Westermark, Ulrica

“…The aim of this thesis was to further understand how defects in the homology-directed repair (HDR) pathway affect tumor formation and development. To study…”
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Expression of transforming‐growth‐factor (TGF)‐β receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF‐β1 by Piek, Ester, Westermark, Ulrica, Kastemar, Marianne, Heldin, Carl‐Henrik, van Zoelen, E. Joop, Nistér, Monica, Ten Dijke, Peter

“…A panel of 6 human glioma cell lines was examined for TGF‐β1 responsiveness. U‐178 MG and U‐251 MG AgCl1 were significantly inhibited by TGF‐β1, while U‐343…”
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