Search Results - "Westermann, Frank"

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis by Vandesompele, Jo, Young, Jennifer, Weinberg, Robert A, Muth, Daniel, Westermann, Frank, Prabhala, Harsha, Speleman, Frank, Pan, Elizabeth, Onder, Tamer T, Mestdagh, Pieter, Reinhardt, Ferenc, Teruya-Feldstein, Julie, Valastyan, Scott, Ma, Li

“…miRNAs can both promote and repress tumorigenesis, and directly control epithelial–mesenchymal transition (EMT). miR-9 (which is upregulated in breast cancer…”
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China's capital flight: Pre- and post-crisis experiences by Cheung, Yin-Wong, Steinkamp, Sven, Westermann, Frank

“…•We study the World Bank residual and trade misinvoicing measures of capital flight.•China's capital flight and its determinants are affected by the crisis in…”
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1p36 tumor suppression--a matter of dosage? by Henrich, Kai-Oliver, Schwab, Manfred, Westermann, Frank

“…A broad range of human malignancies is associated with nonrandom 1p36 deletions, suggesting the existence of tumor suppressors encoded in this region. Evidence…”
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HIF and MYC signaling in adrenal neoplasms of the neural crest: implications for pediatrics by Bechmann, Nicole, Westermann, Frank, Eisenhofer, Graeme

“…Pediatric neural crest-derived adrenal neoplasms include neuroblastoma and pheochromocytoma. Both entities are associated with a high degree of clinical…”
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Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition by Henssen, Anton, Althoff, Kristina, Odersky, Andrea, Beckers, Anneleen, Koche, Richard, Speleman, Frank, Schäfers, Simon, Bell, Emma, Nortmeyer, Maike, Westermann, Frank, De Preter, Katleen, Florin, Alexandra, Heukamp, Lukas, Spruessel, Annika, Astrahanseff, Kathy, Lindner, Sven, Sadowski, Natalie, Schramm, Alexander, Astorgues-Xerri, Lucile, Riveiro, Maria E, Eggert, Angelika, Cvitkovic, Esteban, Schulte, Johannes H

“…Targeting BET proteins was previously shown to have specific antitumoral efficacy against MYCN-amplified neuroblastoma. We here assess the therapeutic efficacy…”
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Transcriptome 3′end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma by Ogorodnikov, Anton, Levin, Michal, Tattikota, Surendra, Tokalov, Sergey, Hoque, Mainul, Scherzinger, Denise, Marini, Federico, Poetsch, Ansgar, Binder, Harald, Macher-Göppinger, Stephan, Probst, Hans Christian, Tian, Bin, Schaefer, Michael, Lackner, Karl J., Westermann, Frank, Danckwardt, Sven

“…Diversification at the transcriptome 3′end is an important and evolutionarily conserved layer of gene regulation associated with differentiation and…”
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Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients by Fey, Dirk, Halasz, Melinda, Dreidax, Daniel, Kennedy, Sean P, Hastings, Jordan F, Rauch, Nora, Munoz, Amaya Garcia, Pilkington, Ruth, Fischer, Matthias, Westermann, Frank, Kolch, Walter, Kholodenko, Boris N, Croucher, David R

“…Signaling pathways control cell fate decisions that ultimately determine the behavior of cancer cells. Therefore, the dynamics of pathway activity may contain…”
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Genome wide DNA methylation analysis identifies novel molecular subgroups and predicts survival in neuroblastoma by Lalchungnunga, H., Hao, Wen, Maris, John M., Asgharzadeh, Shahab, Henrich, Kai-Oliver, Westermann, Frank, Tweddle, Deborah A., Schwalbe, Edward C., Strathdee, Gordon

“…Background Neuroblastoma is the most common malignancy in infancy, accounting for 15% of childhood cancer deaths. Outcome for the high-risk disease remains…”
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Histone Deacetylase 8 in Neuroblastoma Tumorigenesis by Oehme, Ina, Deubzer, Hedwig E, Wegener, Dennis, Pickert, Diana, Linke, Jan-Peter, Hero, Barbara, Kopp-Schneider, Annette, Westermann, Frank, Ulrich, Scott M, von Deimling, Andreas, Fischer, Matthias, Witt, Olaf

“…Purpose: The effects of pan–histone deacetylase (HDAC) inhibitors on cancer cells have shown that HDACs are involved in fundamental tumor biological processes…”
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Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas by Henrich, Kai-Oliver, Bender, Sebastian, Saadati, Maral, Dreidax, Daniel, Gartlgruber, Moritz, Shao, Chunxuan, Herrmann, Carl, Wiesenfarth, Manuel, Parzonka, Martha, Wehrmann, Lea, Fischer, Matthias, Duffy, David J, Bell, Emma, Torkov, Alica, Schmezer, Peter, Plass, Christoph, Höfer, Thomas, Benner, Axel, Pfister, Stefan M, Westermann, Frank

“…The broad clinical spectrum of neuroblastoma ranges from spontaneous regression to rapid progression despite intensive multimodal therapy. This diversity is…”
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Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes by Cobos, Francisco Avila, Panah, Mohammad Javad Najaf, Epps, Jessica, Long, Xiaochen, Man, Tsz-Kwong, Chiu, Hua-Sheng, Chomsky, Elad, Kiner, Evgeny, Krueger, Michael J, di Bernardo, Diego, Voloch, Luis, Molenaar, Jan, van Hooff, Sander R, Westermann, Frank, Jansky, Selina, Redell, Michele L, Mestdagh, Pieter, Sumazin, Pavel

“…RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, scnRNA-seq for short),…”
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Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression by Layer, Julian P., Kronmüller, Marie T., Quast, Thomas, Boorn-Konijnenberg, Debby van den, Effern, Maike, Hinze, Daniel, Althoff, Kristina, Schramm, Alexander, Westermann, Frank, Peifer, Martin, Hartmann, Gunther, Tüting, Thomas, Kolanus, Waldemar, Fischer, Matthias, Schulte, Johannes, Hölzel, Michael

“…Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-cell infiltration and the number of neoantigens caused by…”
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MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma by Lodrini, Marco, Oehme, Ina, Schroeder, Christina, Milde, Till, Schier, Marie C, Kopp-Schneider, Annette, Schulte, Johannes H, Fischer, Matthias, De Preter, Katleen, Pattyn, Filip, Castoldi, Mirco, Muckenthaler, Martina U, Kulozik, Andreas E, Westermann, Frank, Witt, Olaf, Deubzer, Hedwig E

“…MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive…”
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FSTL5 Is a Marker of Poor Prognosis in Non-WNT/Non-SHH Medulloblastoma by Remke, Marc, Hielscher, Thomas, Korshunov, Andrey, Northcott, Paul A, Bender, Sebastian, Kool, Marcel, Westermann, Frank, Benner, Axel, Cin, Huriye, Ryzhova, Marina, Sturm, Dominik, Witt, Hendrik, Haag, Daniel, Toedt, Grischa, Wittmann, Andrea, Schöttler, Anna, von Bueren, André O, von Deimling, Andreas, Rutkowski, Stefan, Scheurlen, Wolfram, Kulozik, Andreas E, Taylor, Michael D, Lichter, Peter, Pfister, Stefan M

“…Integrated genomics approaches have revealed at least four distinct biologic variants of medulloblastoma: WNT (wingless), SHH (sonic hedgehog), group C, and…”
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Customized Oligonucleotide Microarray Gene Expression–Based Classification of Neuroblastoma Patients Outperforms Current Clinical Risk Stratification by OBERTHUER, André, BERTHOLD, Frank, SCHWAB, Manfred, BRORS, Benedikt, WESTERMANN, Frank, FISCHER, Matthias, WARNAT, Patrick, HERO, Barbara, KAHLERT, Yvonne, SPITZ, Rudiger, ERNESTUS, Karen, KONIG, Rainer, HAAS, Stefan, EILS, Roland

“…To develop a gene expression-based classifier for neuroblastoma patients that reliably predicts courses of the disease. Two hundred fifty-one neuroblastoma…”
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Rapid In Vivo Validation of HDAC Inhibitor-Based Treatments in Neuroblastoma Zebrafish Xenografts by Wrobel, Jagoda K, Najafi, Sara, Ayhan, Simay, Gatzweiler, Charlotte, Krunic, Damir, Ridinger, Johannes, Milde, Till, Westermann, Frank, Peterziel, Heike, Meder, Benjamin, Distel, Martin, Witt, Olaf, Oehme, Ina

“…The survival rate among children with relapsed neuroblastomas continues to be poor, and thus new therapeutic approaches identified by reliable preclinical drug…”
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Neuroblastoma: biology and molecular and chromosomal pathology by Schwab, Manfred, Westermann, Frank, Hero, Barbara, Berthold, Frank

“…Neuroblastoma is the most frequently occurring solid tumour in children, with an incidence of 1.3 cases per 100000 children aged 0-14 years. Despite many…”
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Programming a Ferroptosis‐to‐Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy by Vinik, Yaron, Maimon, Avi, Dubey, Vinay, Raj, Harsha, Abramovitch, Ifat, Malitsky, Sergey, Itkin, Maxim, Ma'ayan, Avi, Westermann, Frank, Gottlieb, Eyal, Ruppin, Eytan, Lev, Sima

“…Ferroptosis and apoptosis are key cell‐death pathways implicated in several human diseases including cancer. Ferroptosis is driven by iron‐dependent lipid…”
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Folate Repletion after Deficiency Induces Irreversible Genomic and Transcriptional Changes in Human Papillomavirus Type 16 (HPV16)-Immortalized Human Keratinocytes by Savini, Claudia, Yang, Ruwen, Savelyeva, Larisa, Göckel-Krzikalla, Elke, Hotz-Wagenblatt, Agnes, Westermann, Frank, Rösl, Frank

“…Supplementation of micronutrients like folate is a double-edged sword in terms of their ambivalent role in cell metabolism. Although several epidemiological…”
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Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma by George, Sally L, Lorenzi, Federica, King, David, Hartlieb, Sabine, Campbell, James, Pemberton, Helen, Toprak, Umut H, Barker, Karen, Tall, Jennifer, da Costa, Barbara Martins, van den Boogaard, Marlinde L, Dolman, M Emmy M, Molenaar, Jan J, Bryant, Helen E, Westermann, Frank, Lord, Christopher J, Chesler, Louis

“…In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of…”
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