Search Results - "Westerhof, G R"

Bioproduction of p-Hydroxystyrene from Glucose by the Solvent-Tolerant Bacterium Pseudomonas putida S12 in a Two-Phase Water-Decanol Fermentation by Verhoef, Suzanne, Wierckx, Nick, Westerhof, R.G. Maaike, de Winde, Johannes H, Ruijssenaars, Harald J

“…Two solvent-tolerant Pseudomonas putida S12 strains, originally designed for phenol and p-coumarate production, were engineered for efficient production of…”
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Optimization of the solvent-tolerant Pseudomonas putida S12 as host for the production of p-coumarate from glucose by Nijkamp, Karin, Westerhof, R. G. Maaike, Ballerstedt, Hendrik, de Bont, Jan A. M, Wery, Jan

“…A Pseudomonas putida S12 strain was constructed that is able to convert glucose to p-coumarate via the central metabolite l-tyrosine. Efficient production was…”
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Comparison of different busulfan analogues for depletion of hematopoietic stem cells and promotion of donor-type chimerism in murine bone marrow transplant recipients by WESTERHOF, G. Robbin, PLOEMACHER, Rob E, BOUDEWIJN, Adrie, BLOKLAND, Irene, DILLINGH, Jan H, MCGOWN, Alan T, HADFIELD, John A, DAWSON, Martin J, DOWN, Julian D

“…Busulfan (1,4-butanediol dimethanesulfonate, BU) is relatively unique among other standard chemotherapy compounds in its ability to deplete noncycling…”
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Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates by Jansen, G, Westerhof, G R, Jarmuszewski, M J, Kathmann, I, Rijksen, G, Schornagel, J H

“…This study reports the isolation and characterization of a variant of the human CCRF-CEM leukemia cell line that overproduces the carrier protein responsible…”
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Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice by DOWN, J. D, WESTERHOF, G. R, BOUDEWIJN, A, SETROIKROMO, R, PLOEMACHER, R. E

“…Thiotepa (TT) has long been considered for inclusion in clinical bone marrow transplant (BMT) conditioning regimens in an attempt to prevent allograft…”
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Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity by Westerhof, G R, Schornagel, J H, Kathmann, I, Jackman, A L, Rosowsky, A, Forsch, R A, Hynes, J B, Boyle, F T, Peters, G J, Pinedo, H M

“…The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro against human and murine cell…”
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Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors by JANSEN, G, SCHORNAGEL, J. H, WESTERHOF, G. R, RIJKSEN, G, NEWELL, D. R, JACKMAN, A. L

“…N10-Propargyl-5,8-dideazafolic acid (CB3717) and 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI-198,583) are potent folate-based inhibitors of…”
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In vitro activity of novel antifolates against human squamous carcinoma cell lines of the head and neck with inherent resistance to methotrexate by van der Laan, B F, Jansen, G, Kathmann, G A, Westerhof, G R, Schornagel, J H, Hordijk, G J

“…A series of 7 human squamous carcinoma cell lines of the head and neck (HNSCC), grown in standard medium containing high folate concentrations and in…”
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Identification of a membrane-associated folate-binding protein in human leukemic CCRF-CEM cells with transport-related methotrexate resistance by JANSEN, G, WESTERHOF, G. R, KATHMANN, I, RADEMAKER, B. C, RIJKSEN, G, SCHORNAGEL, J. H

“…CEM/MTX cells, a subline of CCRF-CEM cells resistant to methotrexate (MTX) by virtue of impaired transport by the reduced folate/methotrexate transport system,…”
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Synthesis and biological evaluation of a fluorescent analog of folic acid by McAlinden, Terence P, Hynes, John B, Patil, Shirish A, Westerhof, G. Robbin, Jansen, Gerrit, Schornagel, Jan H, Kerwar, Suresh S, Freisheim, James H

“…A fluorescein derivative of the lysine analogue of folic acid, N alpha-pteroyl-N epilson-(4'-fluoresceinthiocarbamoyl)-L-lysine (PLF), was synthesized as a…”
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Measurement of folylpolyglutamate synthetase activity in head and neck squamous carcinoma cell lines and clinical samples using a new rapid separation procedure by Jansen, G, Schornagel, J H, Kathmann, I, Westerhof, G R, Hordijk, G J, van der Laan, B F

“…The activity of folylpolyglutamate synthetase was measured in extracts of head and neck squamous carcinoma cell lines and in surgical specimens utilizing a new…”
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Cytotoxicity of methotrexate and trimetrexate and its reversal by folinic acid in human leukemic CCRF-CEM cells with carrier-mediated and receptor-mediated folate uptake by van der Veer, L J, Westerhof, G R, Rijksen, G, Schornagel, J H, Jansen, G

“…The cytotoxic effects of the antifolates methotrexate (MTX) and trimetrexate (TMQ) were investigated for two human leukemic CCRF-CEM cell lines, one expressing…”
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Identification of a reduced folate/methotrexate carrier in human KB-cells expressing high levels of membrane associated folate binding protein by Westerhof, G R, Schornagel, J H, Rijnboutt, S, Pinedo, H M, Jansen, G

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The reduced folate/methotrexate carrier and a membrane-associated folate binding protein as transport routes for novel antifolates: structure-activity relationships by Jansen, G, Westerhof, G R, Schornagel, J H, Jackman, A L, Boyle, F T

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Interaction of N-hydroxy(sulfo) succinimide active esters with the reduced folate/methotrexate transport system from human leukemic CCRF-CEM cells by Jansen, G, Westerhof, G R, Rijksen, G, Schornagel, J H

“…The membrane impermeant protein cross-linker 3,3'-dithiobissulfosuccinimidyl propionate (DTSSP) is a well-known inhibitor of human erythrocyte band 3-mediated…”
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Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein by Westerhof, G R, Rijnboutt, S, Schornagel, J H, Pinedo, H M, Peters, G J, Jansen, G

“…The role of a membrane-associated folate binding protein (mFBP) in transport of folate analogues was investigated in three epithelial cell lines that were…”
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Maintaining High Levels of Syngeneic Bone Marrow Engraftment While Omitting Cyclophosphamide in Busulfan-Containing Conditioning Regimens by Robbin Westerhof, G., Ploemacher, Rob E., Down, Julian D.

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Expression of a folate binding protein in L1210 cells grown in low folate medium by JANSEN, G, KATHMANN, I, RADEMAKER, B. C, BRAAKHUIS, B. J. M, ROBBIN WESTERHOF, G, RIJKSEN, G, SCHORNAGEL, J. H

“…We have isolated variants of L1210 cells (L1210B) expressing, in addition to the "classical" high affinity/low capacity system for reduced folate uptake, high…”
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Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells : role of Carrier- and receptor-mediated transport systems by WESTERHOF, G. R, JANSEN, G, VAN EMMERIK, N, KATHMANN, I, RIJKSEN, G, JACKMAN, A. L, SHORNAGEL, J. H

“…L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein…”
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Growth-inhibitory effects of 5,10-dideazatetrahydrofolic acid on variant murine L1210 and human CCRF-CEM leukemia cells with different membrane-transport characteristics for (anti)folate compounds by Jansen, G, Westerhof, G R, Kathmann, I, Rijksen, G, Schornagel, J H

“…5,10-Dideazatetrahydrofolic acid (DDATHF) is a potent inhibitor of glycinamide ribonucleotide transformylase, one of the folate-dependent key enzymes in de…”
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