Search Results - "Westergaard, Majken"

SPC3042: a proapoptotic survivin inhibitor by Hansen, Jens Bo, Fisker, Niels, Westergaard, Majken, Kjaerulff, Lene Sønderby, Hansen, Henrik Frydenlund, Thrue, Charlotte Albaek, Rosenbohm, Christoph, Wissenbach, Margit, Orum, Henrik, Koch, Troels

“…The ability to regulate the cellular homeostasis of a higher organism through tight control of apoptosis and cell division is crucial for life. Dysregulation…”
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Modulation of Keratinocyte Gene Expression and Differentiation by PPAR-Selective Ligands and Tetradecylthioacetic Acid by Westergaard, Majken, Henningsen, Jeanette, Kratchmarova, Irina, Kristiansen, Karsten, Svendsen, Morten Lyne, Johansen, Claus, Jensen, Uffe Birk, Schrøder, Henrik Daa, Berge, Rolf Kristian, Iversen, Lars, Bolund, Lars, Kragballe, Knud

“…Peroxisome proliferator-activated receptors (PPARs) are pleiotropic regulators of growth and differentiation of many cell types. We have performed a…”
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1α,25-Dihydroxyvitamin D3 Stimulates Activator Protein 1 DNA-Binding Activity by a Phosphatidylinositol 3-Kinase/Ras/MEK/Extracellular Signal Regulated Kinase 1/2 and c-Jun N-Terminal Kinase 1-Dependent Increase in c-Fos, Fra1, and c-Jun Expression in Human Keratinocytes by Johansen, Claus, Kragballe, Knud, Iversen, Lars, Henningsen, Jeanette, Westergaard, Majken, Kristiansen, Karsten

“…1α,25-Dihydroxyvitamin D3 added to human keratinocytes increases differentiation through an activation of the transcription factor activator protein 1. We have…”
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A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth by Greenberger, Lee M., Horak, Ivan D., Filpula, David, Sapra, Puja, Westergaard, Majken, Frydenlund, Henrik F., Albæk, Charlotte, Schrøder, Henrik, Ørum, Henrik

“…Abstract Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a critical role in angiogenesis, survival, metastasis, drug resistance, and…”
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Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality by Elmén, Joacim, Thonberg, Håkan, Ljungberg, Karl, Frieden, Miriam, Westergaard, Majken, Xu, Yunhe, Wahren, Britta, Liang, Zicai, Ørum, Henrik, Koch, Troels, Wahlestedt, Claes

“…Therapeutic application of the recently discovered small interfering RNA (siRNA) gene silencing phenomenon will be dependent on improvements in molecule…”
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Inverse Regulation of the Nuclear Factor-κB Binding to the p53 and Interleukin-8 κB Response Elements in Lesional Psoriatic Skin by Johansen, Claus, Flindt, Esben, Kragballe, Knud, Henningsen, Jeanette, Westergaard, Majken, Kristiansen, Karsten, Iversen, Lars

“…Nuclear factor-κB (NF-κB) is an inducible nuclear transcription factor regulating a range of cellular processes. An imbalance of the DNA binding activity of…”
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Expression and Localization of Peroxisome Proliferator-Activated Receptors and Nuclear Factor κB in Normal and Lesional Psoriatic Skin by Westergaard, Majken, Henningsen, Jeanette, Rasmussen, Sofie, Kristiansen, Karsten, Johansen, Claus, Svendsen, Morten Lyhne, Jensen, Uffe Birk, Schrøder, Henrik Daa, Staels, Bart, Iversen, Lars, Bolund, Lars, Kragballe, Knud

“…Abnormal epidermal proliferation and differentiation characterize the inflammatory skin disease psoriasis. Here we demonstrate that expression of PPARδ mRNA…”
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Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter by HANSEN, Jens J, BROSS, Peter, WESTERGAARD, Majken, NIELSEN, Marit Nyholm, EIBERG, Hans, BØRGLUM, Anders D, MOGENSEN, Jens, KRISTIANSEN, Karsten, BOLUND, Lars, GREGERSEN, Niels

“…Although the mitochondrial chaperonin Hsp60 and its co-chaperonin Hsp10 have received great attention in the last decade, and it has been proposed that…”
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Expanding the design horizon of antisense oligonucleotides with alpha‐l‐LNA by Frieden, Miriam, Christensen, Signe M., Mikkelsen, Nikolaj D., Rosenbohm, Christoph, Thrue, Charlotte A., Westergaard, Majken, Hansen, Henrik F., Ørum, Henrik, Koch, Troels

“…Oligonucleotides containing Locked Nucleic Acids (LNA) to various extents and at various positions were evaluated for antisense activity, RNase H recruitment,…”
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Survivin mRNA Antagonists Using Locked Nucleic Acid, Potential for Molecular Cancer Therapy by Fisker, Niels, Westergaard, Majken, Hansen, Henrik Frydenlund, Hansen, Jens Bo

“…We have investigated the effects of different locked nucleic acid modified antisense mRNA antagonists against Survivin in a prostate cancer model. These mRNA…”
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A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth by Greenberger, Lee M, Horak, Ivan D, Filpula, David, Sapra, Puja, Westergaard, Majken, Frydenlund, Henrik F, Albaek, Charlotte, Schrøder, Henrik, Ørum, Henrik

“…Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a critical role in angiogenesis, survival, metastasis, drug resistance, and glucose…”
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Inverse Regulation of the Nuclear Factor-B Binding to the p53 and Interleukin-8 B Response Elements in Lesional Psoriatic Skin by Johansen, Claus, Flindt, Esben, Kragballe, Knud, Henningsen, Jeanette, Westergaard, Majken, Kristiansen, Karsten, Iversen, Lars

“…Nuclear factor-B (NF-B) is an inducible nuclear transcription factor regulating a range of cellular processes. An imbalance of the DNA binding activity of NF-B…”
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Inverse regulation of the nuclear factor-kappaB binding to the p53 and interleukin-8 kappaB response elements in lesional psoriatic skin by Johansen, Claus, Flindt, Esben, Kragballe, Knud, Henningsen, Jeanette, Westergaard, Majken, Kristiansen, Karsten, Iversen, Lars

“…Nuclear factor-kappaB (NF-kappaB) is an inducible nuclear transcription factor regulating a range of cellular processes. An imbalance of the DNA binding…”
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SPC2996 - A New Bcl-2 Inhibitor for the Treatment of CLL by Kearney, Phil, Westergaard, Majken, Bo Hansen, Jens, Hansen, Henrik F., Thrue, Charlotte A., Frieden, Miriam, Koch, Troels, Ørum, Henrik

“…The proapoptotic oligonucleotide agent - SPC2996, has been developed by Santaris Pharma A/S, as a specific Bcl-2 mRNA antagonist. SPC2996 was selected from our…”
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siRNA Versus Antisense Locked Nucleic Acids: Stay Single by Kearney, Phil, Westergaard, Majken, Hansen, Henrik F., Staarup, Ellen M., Koch, Troels, Ørum, Henrik, Hansen, Jens Bo

“…Much discussion has centred around the utility and benefits of siRNA in both target validation and as a therapeutic option. This has been driven by significant…”
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1[alpha],25-Dihydroxyvitamin D3 Stimulates Activator Protein 1 DNA-Binding Activity by a Phosphatidylinositol 3-Kinase/Ras/MEK/Extracellular Signal Regulated Kinase 1/2 and c-Jun N-Terminal Kinase 1-Dependent Increase in c-Fos, Fra1, and c-Jun Expression in Human Keratinocytes by Johansen, Claus, Kragballe, Knud, Henningsen, Jeanette, Westergaard, Majken, Kristiansen, Karsten, Iversen, Lars

“…1alpha,25-Dihydroxyvitamin D3 added to human keratinocytes increases differentiation through an activation of the transcription factor activator protein 1. We…”
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1alpha,25-dihydroxyvitamin D3 stimulates activator protein 1 DNA-binding activity by a phosphatidylinositol 3-kinase/Ras/MEK/extracellular signal regulated kinase 1/2 and c-Jun N-terminal kinase 1-dependent increase in c-Fos, Fra1, and c-Jun expression in human keratinocytes by Johansen, Claus, Kragballe, Knud, Henningsen, Jeanette, Westergaard, Majken, Kristiansen, Karsten, Iversen, Lars

“…1alpha,25-Dihydroxyvitamin D3 added to human keratinocytes increases differentiation through an activation of the transcription factor activator protein 1. We…”
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Inverse regulation of the nuclear factor-κB binding to the p53 and lnterleukin-8 κB response elements in lesional psoriatic skin by NICKOLOFF, Brian J, BEN-NERIAH, Yinon, PIKARSKV, Eli, JOHANSEN, Claus, FLINDT, Esben, KRAGBALLE, Knud, HENNINGSEN, Jeanette, WESTERGAARD, Majken, KRISTIANSEN, Karsten, IVERSEN, Lars

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Expression and localization of peroxisome proliferator-activated receptors and nuclear factor kappaB in normal and lesional psoriatic skin by Westergaard, Majken, Henningsen, Jeanette, Johansen, Claus, Rasmussen, Sofie, Svendsen, Morten Lyhne, Jensen, Uffe Birk, Schrøder, Henrik Daa, Staels, Bart, Iversen, Lars, Bolund, Lars, Kragballe, Knud, Kristiansen, Karsten

“…Abnormal epidermal proliferation and differentiation characterize the inflammatory skin disease psoriasis. Here we demonstrate that expression of PPARdelta…”
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Expression and localization of peroxisome proliferator-activated receptors and nuclear factor KB in normal and lesional psoriatic skin by WESTERGAARD, Majken, HENNINGSEN, Jeanette, KRAGBALLE, Knud, KRISTIANSEN, Karsten, JOHANSEN, Claus, RASMUSSEN, Sofic, SVENDSEN, Morten Lyhne, JENSEN, Uffe Birk, SCHRØDER, Henrik Daa, STAELS, Bart, IVERSEN, Lars, BOLUND, Lars

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