Search Results - "Wester, M R"

CYP2C19 Participates in Tolbutamide Hydroxylation by Human Liver Microsomes by WESTER, M. R, LASKER, J. M, JOHNSON, E. F, RAUCY, J. L

“…Tolbutamide is a sulfonylurea-type oral hypoglycemic agent whose action is terminated by hydroxylation of the tolylsulfonyl methyl moiety catalyzed by…”
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Identification of Human CYP2C19 Residues that Confer S-Mephenytoin 4‘-Hydroxylation Activity to CYP2C9 by Tsao, Cheng-Chung, Wester, Michael R, Ghanayem, Burhan, Coulter, Sherry J, Chanas, Brian, Johnson, Eric F, Goldstein, Joyce A

“…CYP2C19 is selective for the 4‘-hydroxylation of S-mephenytoin while the highly similar CYP2C9 has little activity toward this substrate. To identify critical…”
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Rabbit Pregnane X Receptor Is Activated by Rifampicin by SAVAS, U, WESTER, M. R, GRIFFIN, K. J, JOHNSON, E. F

“…Reverse transcriptase-polymerase chain reaction was used to amplify a partial cDNA from rabbit lung mRNA that shared 77% protein sequence identity with the…”
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Human Lymphocyte Cytochrome P450 2E1, a Putative Marker for Alcohol-Mediated Changes in Hepatic Chlorzoxazone Activity by RAUCY, J. L, SCHULTZ, E. D, WESTER, M. R, ARORA, S, JOHNSTON, D. E, OMDAHL, J. L, CARPENTER, S. P

“…Cytochrome P450 (CYP) 2E1 is implicated in a variety of chemically initiated hepatotoxicities, including alcoholic liver disease. These pathological conditions…”
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Interleukin-6 and Interleukin-1 Production in Acute Leukemia With Monocytoid Differentiation by van der Schoot, C. Ellen, Jansen, Patty, Poorter, Mirella, Wester, Mieke R., von dem Borne, Albert E.G. Kr, Aarden, Lucien A., van Oers, Rien H.J.

“…Several authors have reported the in vitro production of colony-stimulating factors (CSF) and interleukin-1 (IL-1) by the neoplastic cells from patients with…”
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Characterization of CYP2C19 and CYP2C9 from Human Liver: Respective Roles in Microsomal Tolbutamide,S-Mephenytoin, and Omeprazole Hydroxylations by Lasker, Jerome M., Wester, Michael R., Aramsombatdee, Eileen, Raucy, Judy L.

“…Individuals with drug metabolism polymorphisms involving CYP2C enzymes exhibit deficient oxidation of important therapeutic agents, includingS-mephen-ytoin,…”
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Efficiency of white cell filtration and a freeze-thaw procedure for removal of HIV-infected cells from blood by Bruisten, S M, Tersmette, M, Wester, M R, Vos, A H, Koppelman, M H, Huisman, J G

“…Strategies for diminishing the risk of blood transfusion-associated transmission of HIV-1 were evaluated. HIV-1-infected peripheral blood mononuclear cells…”
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Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles by Spatzenegger, M, Wang, Q, He, Y Q, Wester, M R, Johnson, E F, Halpert, J R

“…The molecular basis for reversible inhibition of rabbit CYP2B4 and CYP2B5 and rat CYP2B1 by phenylimidazoles was assessed with active-site mutants and new…”
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A new radioimmunoassay for the detection of small amounts of white cells and platelets in red cell concentrates: implications for blood transfusion by Webster, M R, Prins, H K, Huisman, J G

“…In the procedure for quality control of red cell concentrates, made white cell (WBC)-poor by filtration, the particle-counting technique was found to be…”
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Confirmation of HIV seropositivity: comparison of a novel radioimmunoprecipitation assay to immunoblotting and virus culture by Tersmette, M, Lelie, P N, van der Poel, C L, Wester, M R, de Goede, R E, Lange, J M, Miedema, F, Huisman, J G

“…A recently developed radioimmunoprecipitation assay, using 125I-labeled human immunodeficiency virus (HIV) viral proteins enriched for glycoproteins gp120env,…”
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Characterization of a human plasmacytoma line by Weinreich, S S, von dem Borne, A E, van Lier, R A, Feltkamp, C A, Slater, R M, Wester, M R, Zeijlemaker, W P

“…The TH line was established by bringing tumour cells from a multiple myeloma patient into suspension culture and subsequently cloning them by limiting…”
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Predicted Chemical Warfare Agent VX Toxicity to Uniformed Soldier Using Parathion in Vitro Human Skin Exposure and Absorption by Wester, Rebecca M., Tanojo, Hanafi, Maibach, Howard I., Wester, Ronald C.

“…Chemical warfare agents (CWA) are easily and inexpensively produced and are a significant threat to military forces and the public. Most well-known CWAs are…”
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Re: Patient advance directives by Wester, R M

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The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-Å Resolution by Wester, Michael R, Yano, Jason K, Schoch, Guillaume A, Yang, Christine, Griffin, Keith J, Stout, C David, Johnson, Eric F

“…The structure of human P450 2C9 complexed with flurbiprofen was determined to 2.0 Å by x-ray crystallography. In contrast to other structurally characterized…”
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Epidural block anesthesia for cordotomy by KRUMPERMAN, L W, MURTAGH, F, WESTER, M R

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EFFECT OF RESERPINE ON CARDIAC FUNCTION DURING THIOPENTAL-CYCLOPROPANE ANESTHESIA IN THE DOG by RUSY, B F, WITHERSPOON, C D, MONTANER, C G, FREEMAN, E, MACHADO, R A, WESTER, M R, KRUMPERMAN, L W

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Anesthesia and analgesia by WESTER, M R, KRUMPERMAN, L W

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Immediate cardiovascular and respiratory adjustments to pneumonectomy by LONG, J H, WESTER, M R, OPPENHEIMER, M J

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Purification and crystallization of N-terminally truncated forms of microsomal cytochrome P450 2C5 by Wester, Michael R, Stout, C David, Johnson, Eric F

“…Engineering more soluble forms of P450 2C5 has contributed to the crystallization of the enzyme. When detergents are used in both crystallization and…”
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Lateral position mattress by WESTER, M R

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