Search Results - "Westendorp, Rudi G.J"

Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population by Ling, Carolina H.Y, de Craen, Anton J.M, Slagboom, Pieternella E, Gunn, Dave A, Stokkel, Marcel P.M, Westendorp, Rudi G.J, Maier, Andrea B

“…Summary Background & aims Body composition measurement is a valuable tool for assessing nutritional status and physical fitness in a variety of clinical…”
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Resting heart rate, heart rate variability and functional decline in old age by Ogliari, Giulia, Mahinrad, Simin, Stott, David J, Jukema, J Wouter, Mooijaart, Simon P, Macfarlane, Peter W, Clark, Elaine N, Kearney, Patricia M, Westendorp, Rudi G J, de Craen, Anton J M, Sabayan, Behnam

“…Heart rate and heart rate variability, markers of cardiac autonomic function, have been linked with cardiovascular disease. We investigated whether heart rate…”
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Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations by Beenakker, Karel G.M., Westendorp, Rudi G.J., de Craen, Anton J.M., Chen, Sijia, Raz, Yotam, Ballieux, Bart E.P.B., Nelissen, Rob G.H.H., Later, Alexander F.L., Huizinga, Tom W., Slagboom, Pieternella E., Boomsma, Dorret I., Maier, Andrea B.

“…The incidence of bacterial infections and sepsis, as well as the mortality risk from sepsis, is sex specific. These clinical findings have been attributed to…”
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Gene dose of apolipoprotein E and age-related hearing loss by Kurniawan, Clara, Westendorp, Rudi G.J, de Craen, Anton J.M, Gussekloo, Jacobijn, de Laat, Jan, van Exel, Eric

“…Abstract Next to outer hair cell dysfunction, age-related hearing loss may be explained by apolipoprotein E (APOE) genotype. In the Leiden 85-plus Study, a…”
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Framingham Stroke Risk Score and Cognitive Impairment for Predicting First-Time Stroke in the Oldest Old by Sabayan, Behnam, Gussekloo, Jacobijn, de Ruijter, Wouter, Westendorp, Rudi G.J, de Craen, Anton J.M

“…BACKGROUND AND PURPOSE—Predictive value of the conventional risk factors for stroke attenuates with age. Cognitive impairment has been implicated as a…”
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Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly by Akao, Hironobu, Polisecki, Eliana, Kajinami, Kouji, Trompet, Stella, Robertson, Michele, Ford, Ian, Jukema, J. Wouter, de Craen, Anton J.M, Westendorp, Rudi G.J, Shepherd, James, Packard, Christopher, Buckley, Brendan M, Schaefer, Ernst J

“…Abstract Our goal was to determine whether genetic variation at genes affecting statin metabolism or targets of statin therapy would influence low density…”
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C-reactive protein and prediction of coronary heart disease and global vascular events in the prospective study of pravastatin in the elderly at risk (PROSPER) by SATTAR, Naveed, MURRAY, Heather M, WOUTER JUKEMA, J, KAMPER, Adriaan M, MACFARLANE, Peter W, MURPHY, Michael B, PACKARD, Chris J, PERRY, Ivan J, STOTT, David J, SWEENEY, Brian J, TWOMEY, Cillian, WESTENDORP, Rudi G. J, MCCONNACHIE, Alex, SHEPHERD, James, BLAUW, Gerard J, BOLLEN, Edward L. E. M, BUCKLEY, Brendan M, COBBE, Stuart M, FORD, Ian, GAW, Allan, HYLAND, Michael

“…The role of C-reactive protein (CRP) in predicting vascular events and response to statin therapy remains uncertain. Additional large prospective studies are…”
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KIF6 , LPA , TAS2R50 , and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly by Akao, Hironobu, Polisecki, Eliana, Kajinami, Kouji, Trompet, Stella, Robertson, Michele, Ford, Ian, Jukema, J. Wouter, de Craen, Anton J.M, Westendorp, Rudi G.J, Shepherd, James, Packard, Christopher, Buckley, Brendan M, Schaefer, Ernst J

“…Abstract Single nucleotide polymorphisms (SNPs) at the KIF6 (kinesin like protein 6, rs20455 or 719Arg), LPA (lipoprotein(a), rs3798220), TAS2R50 (taste…”
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Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER by Polisecki, Eliana, Muallem, Hind, Maeda, Nobuyo, Peter, Inga, Robertson, Michele, McMahon, Alex D, Ford, Ian, Packard, Christopher, Shepherd, James, Jukema, J. Wouter, Westendorp, Rudi G.J, de Craen, Anton J.M, Buckley, Brendan M, Ordovas, Jose M, Schaefer, Ernst J

“…Abstract Our purpose was to evaluate associations of single nucleotide polymorphisms (SNPs) at the low density lipoprotein (LDL) receptor (LDLR C44857T, minor…”
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Genetic Variation in Pentraxin (PTX) 3 Gene Associates with PTX3 Production and Fertility in Women by May, Linda, Kuningas, Maris, Bodegom, David van, Meij, Hans J, Frolich, Marijke, Slagboom, P. Eline, Mantovani, Alberto, Westendorp, Rudi G.J

“…Pentraxin 3 (PTX3) plays an important role in innate immune responses and in female fertility, as discovered with studies in mice. However, the role of PTX3 in…”
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Relation between replicative senescence of human fibroblasts and life history characteristics by Maier, Andrea B, Westendorp, Rudi G.J

“…Abstract Replicative ageing of fibroblasts in vitro has often been used as a model for organismal ageing. The general assumption that the ageing process is…”
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Are we becoming less disposable? by Westendorp, Rudi G J

“…Evolution has programmed us for early survival and reproduction but has left us vulnerable to disease in old age. In our present affluent environment, we are…”
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Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the prospective study of pravastatin in the elderly at risk (PROSPER) by PACKARD, Chris J, FORD, Ian, HYLAND, Michael, JUKEMA, J. Wouter, KAMPER, Adriaan M, MACFARLANE, Peter W, PERRY, Ivan J, STOTT, David J, SWEENEY, Brian J, TWOMEY, Cillian, WESTENDORP, Rudi G. J, ROBERTSON, Michele, SHEPHERD, James, BLAUW, Gerard J, MURPHY, Michael B, BOLLEN, Edward L. E. M, BUCKLEY, Brendan M, COBBE, Stuart M, GAW, Allan

“…Statins are important in vascular disease prevention in the elderly. However, the best method of selecting older patients for treatment is uncertain. We…”
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The design of a prospective study of pravastatin in the elderly at risk (PROSPER) by Shepherd, James, Blauw, Gerard Jan, Murphy, Michael B, Cobbe, Stuart M, Bollen, Edward L.E.M, Buckley, Brendan M, Ford, Ian, Jukema, J.Wouter, Hyland, Michael, Gaw, Allan, Lagaay, A.Margot, Perry, Ivan J, Macfarlane, Peter W, Meinders, A.Edo, Sweeney, Brian J, Packard, Chris J, Westendorp, Rudi G.J, Twomey, Cillian, Stott, David J

“…The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) is a randomized, double-blind, placebo-controlled trial designed to test the hypothesis…”
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Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old by Taekema, Diana G., Gussekloo, Jacobijn, Maier, Andrea B., Westendorp, Rudi G. J., de Craen, Anton J. M.

“…Background: muscle wasting is associated with a detrimental outcome in older people. Muscle strength measurements could be useful as part of a clinical…”
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Successful ageing: A study of the literature using citation network analysis by Kusumastuti, Sasmita, Derks, Marloes G.M, Tellier, Siri, Di Nucci, Ezio, Lund, Rikke, Mortensen, Erik Lykke, Westendorp, Rudi G.J

“…Highlights • This novel, hypothesis-free and quantitative analysis of citation networks explores the literature on successful ageing. • From 1902 through 2015,…”
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Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study by Ling, Carolina H Y, Taekema, Diana, de Craen, Anton J M, Gussekloo, Jacobijn, Westendorp, Rudi G J, Maier, Andrea B

“…Poor muscular strength has been shown to be associated with increased morbidity and mortality in diverse samples of middle-aged and elderly people. However,…”
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Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults: The Danish Nurse cohort by Liu, Shuo, Lim, Youn-Hee, Pedersen, Marie, Jørgensen, Jeanette T., Amini, Heresh, Cole-Hunter, Thomas, Mehta, Amar J., So, Rina, Mortensen, Laust H., Westendorp, Rudi G.J., Loft, Steffen, Bräuner, Elvira V., Ketzel, Matthias, Hertel, Ole, Brandt, Jørgen, Jensen, Steen S., Christensen, Jesper H., Sigsgaard, Torben, Geels, Camilla, Frohn, Lise M., Brborić, Maja, Radonić, Jelena, Sekulic, Maja Turk, Bønnelykke, Klaus, Backalarz, Claus, Simonsen, Mette K., Andersen, Zorana J.

“…•Long-term exposure to air pollution can increase the risk of asthma in adults.•Road traffic noise is not independently associated with adult-asthma…”
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The number of p16INK4a positive cells in human skin reflects biological age by Waaijer, Mariëtte E.C., Parish, William E., Strongitharm, Barbara H., van Heemst, Diana, Slagboom, Pieternella E., de Craen, Anton J.M., Sedivy, John M., Westendorp, Rudi G.J., Gunn, David A., Maier, Andrea B.

“…Summary Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells…”
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Are skin senescence and immunosenescence linked within individuals? by Waaijer, Mariëtte E. C., Goldeck, David, Gunn, David A., Heemst, Diana, Westendorp, Rudi G. J., Pawelec, Graham, Maier, Andrea B.

“…With advancing age, many organs exhibit functional deterioration. The age‐associated accumulation of senescent cells is believed to represent one factor…”
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