Search Results - "Westaway, D."

Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis by Maulik, M., Westaway, D., Jhamandas, J. H., Kar, S.

“…Alzheimer’s disease (AD) is a complex multifactorial neurodegenerative disorder believed to be initiated by accumulation of amyloid β (Aβ)-related peptides…”
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Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease by Amtul, Z, Wang, L, Westaway, D, Rozmahel, R.F

“…Abstract Estrogen (17β-estradiol) plays key regulatory roles in a variety of physiological and biological processes. Several lines of evidence also support its…”
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The Effects of N-terminal Mutations on β-amyloid Peptide Aggregation and Toxicity by Foroutanpay, B.V., Kumar, J., Kang, S.G., Danaei, N., Westaway, D., Sim, V.L., Kar, S.

“…•Rodents may not develop Alzheimer disease due to sequence differences in β-amyloid.•Humanizing rat β-amyloid reduced fibril but preserved oligomer…”
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Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against β‐amyloid‐toxicity by Wang, Y., Wu, Q., Anand, B. G., Karthivashan, G., Phukan, G., Yang, J., Thinakaran, G., Westaway, D., Kar, S.

“…Background Evidence suggests that amyloid β (Aβ) peptides play an important role in the degeneration of neurons during the development of Alzheimer's disease…”
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Pramlintide Antagonizes Beta Amyloid (Aβ)- and Human Amylin-Induced Depression of Hippocampal Long-Term Potentiation by Kimura, R., MacTavish, D., Yang, J., Westaway, D., Jhamandas, Jack H.

“…Accumulation of amyloid-β peptide (Aβ) is a pathological hallmark of Alzheimer’s disease (AD). We have previously demonstrated that electrophysiological and…”
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Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model by Steele, J W, Lachenmayer, M L, Ju, S, Stock, A, Liken, J, Kim, S H, Delgado, L M, Alfaro, I E, Bernales, S, Verdile, G, Bharadwaj, P, Gupta, V, Barr, R, Friss, A, Dolios, G, Wang, R, Ringe, D, Fraser, P, Westaway, D, St George-Hyslop, P H, Szabo, P, Relkin, N R, Buxbaum, J D, Glabe, C G, Protter, A A, Martins, R N, Ehrlich, M E, Petsko, G A, Yue, Z, Gandy, S

“…Latrepirdine (Dimebon) is a pro-neurogenic, antihistaminic compound that has yielded mixed results in clinical trials of mild to moderate Alzheimer's disease,…”
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Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4-10 and inhibit cytotoxicity and fibrillogenesis by McLaurin, J, Przybylski, M, Cecal, R, Kierstead, M.E, Tian, X, Phinney, A.L, Manea, M, French, J.E, Lambermon, M.H.L, Darabie, A.A, Brown, M.E, Janus, C, Chishti, M.A, Horne, P, Westaway, D, Fraser, P.E, Mount, H.T.J, St George-Hyslop, P

“…Immunization of transgenic mouse models of Alzheimer disease using amyloid-beta peptide (Abeta) reduces both the Alzheimer disease-like neuropathology and the…”
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Focally Elevated Creatine Detected in Amyloid Precursor Protein (APP) Transgenic Mice and Alzheimer Disease Brain Tissue by Gallant, Meghan, Rak, Margaret, Szeghalmi, Adriana, Del Bigio, Marc R., Westaway, David, Yang, Jin, Julian, Robert, Gough, Kathleen M.

“…The creatine/phosphocreatine system, regulated by creatine kinase, plays an important role in maintaining energy balance in the brain. Energy metabolism and…”
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Minimizing the source of nociception and its concurrent effect on sensory hypersensitivity: an exploratory study in chronic whiplash patients by Schneider, Geoff M, Smith, Ashley D, Hooper, Allen, Stratford, Paul, Schneider, Kathryn J, Westaway, Michael D, Frizzell, Bevan, Olson, Lee

“…The cervical zygapophyseal joints may be a primary source of pain in up to 60% of individuals with chronic whiplash associated disorders (WAD) and may be a…”
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Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP + PS1 transgenic mouse brains by Amritraj, A, Hawkes, C, Phinney, A.L, Mount, H.T, Scott, C.D, Westaway, D, Kar, S

“…Abstract The insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor participates in the trafficking of lysosomal enzymes from the trans-Golgi…”
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Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin ,a component of the presenilin protein complex by St George-Hyslop, P, Nishimura, M, Yu, G, Levesque, G, Zhang, D.M, Ruel, L, Chen, F, Milman, P, Holmes, E, Liang, Y, Kawarai, T, Jo, E, Supala, A, Rogaeva, E, Xu, D -M, Janus, C, Levesque, L, Bi, Q, Duthie, M, Rozmahel, R, Mattila, K, Lannfelt, L, Westaway, D, Mount, H.T.J, Woodgett, J, Fraser, P.E

“…The presenilin proteins are components of high-molecular-weight protein complexes in the endoplasmic reticulum and Golgi apparatus that also contain…”
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The patient-specific functional scale: validation of its use in persons with neck dysfunction by Westaway, M D, Stratford, P W, Binkley, J M

“…Self-report measures of disability are being used more frequently to assess patients' outcomes in clinical practice. This study examines the reliability,…”
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Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes by Janus, C, D’Amelio, S, Amitay, O, Chishti, M.A, Strome, R, Fraser, P, Carlson, G.A, Roder, J.C, St. George–Hyslop, P, Westaway, D

“…Dominant mutations in the Presenilin 1 gene are linked to an aggressive, early-onset form of familial Alzheimer’s Disease (FAD). Spatial memory of transgenic…”
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Presenilin-1 Regulates the Neuronal Threshold to Excitotoxicity Both Physiologically and Pathologically by Grilli, M., Diodato, E., Lozza, G., Brusa, R., Casarini, M., Uberti, D., Rozmahel, R., Westaway, D., St George-Hyslop, P., Memo, M., Ongini, E.

“…A direct pathophysiological role of Familial Alzheimer's Disease (FAD)-associated Presenilin 1 (PS1) mutations in neuronal vulnerability remains a…”
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Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie by WESTAWAY, D, ZULIANI, V, COOPER, C. M, DA COSTA, M, NEUMAN, S, JENNY, A. L, DETWILER, L, PRUSINER, S. B

“…Natural scrapie has been viewed both as a recessive trait and as a contagious disease modulated by a host locus. To address this conundrum, we determined the…”
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Normal brain development in PS1 hypomorphic mice with markedly reduced γ-secretase cleavage of βAPP by ROZMAHEL, R, HUANG, J, SCHMIDT, S. D, MERCKEN, M, BERGERON, C, WESTAWAY, D, ST GEORGE-HYSLOP, P, CHEN, F, LIANG, Y, NGUYEN, V, IKEDA, M, LEVESQUE, G, YU, G, NISHIMURA, M, MATHEWS, P

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Object Recognition Memory and Cholinergic Parameters in Mice Expressing Human Presenilin 1 Transgenes by Vaucher, E., Fluit, P., Chishti, M.A., Westaway, D., Mount, H.T.J., Kar, S.

“…Most autosomal dominant forms of Alzheimer disease (AD) are related to missense mutations in the human presenilin (PS) 1 gene. Although the underlying…”
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Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene by Basler, K, Oesch, B, Scott, M, Westaway, D, Wälchli, M, Groth, D F, McKinley, M P, Prusiner, S B, Weissmann, C

“…PrP 27-30 is the major protein in purified preparations of scrapie agent. An almost complete PrP cDNA was used to select PrP-related genomic clones from normal…”
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The International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society grading system has limited prognostic significance in advanced resected pulmonary adenocarcinoma by Westaway, Darin D., Toon, Christopher W., Farzin, Mahtab, Sioson, Loretta, Watson, Nicole, Brady, Peter W., Marshman, David, Mathur, Manu M., Gill, Anthony J.

“…The International Association for the Study of Lung Cancer, the American Thoracic Society and the European Respiratory Society (IASLC/ATS/ERS) system which…”
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Prion Isolate Specified Allotypic Interactions between the Cellular and Scrapie Prion Proteins in Congenic and Transgenic Mice by Carlson, George A., Ebeling, Christine, Yang, Shu-Lian, Telling, Glenn, Torchia, Marilyn, Groth, Darlene, Westaway, David, DeArmond, Stephen J., Prusiner, Stanley B.

“…Different prion isolates, often referred to as "strains," present an enigma because considerable evidence argues that prions are devoid of nucleic acid. To…”
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