Search Results - "West, Mallory L."

Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation by Jenq, Robert R, Ubeda, Carles, Taur, Ying, Menezes, Clarissa C, Khanin, Raya, Dudakov, Jarrod A, Liu, Chen, West, Mallory L, Singer, Natalie V, Equinda, Michele J, Gobourne, Asia, Lipuma, Lauren, Young, Lauren F, Smith, Odette M, Ghosh, Arnab, Hanash, Alan M, Goldberg, Jenna D, Aoyama, Kazutoshi, Blazar, Bruce R, Pamer, Eric G, van den Brink, Marcel R M

“…Despite a growing understanding of the link between intestinal inflammation and resident gut microbes, longitudinal studies of human flora before initial onset…”
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Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease by Hanash, Alan M., Dudakov, Jarrod A., Hua, Guoqiang, O’Connor, Margaret H., Young, Lauren F., Singer, Natalie V., West, Mallory L., Jenq, Robert R., Holland, Amanda M., Kappel, Lucy W., Ghosh, Arnab, Tsai, Jennifer J., Rao, Uttam K., Yim, Nury L., Smith, Odette M., Velardi, Enrico, Hawryluk, Elena B., Murphy, George F., Liu, Chen, Fouser, Lynette A., Kolesnick, Richard, Blazar, Bruce R., van den Brink, Marcel R.M.

“…Little is known about the maintenance of intestinal stem cells (ISCs) and progenitors during immune-mediated tissue damage or about the susceptibility of…”
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Interleukin-22 Drives Endogenous Thymic Regeneration in Mice by Dudakov, Jarrod A., Hanash, Alan M., Jenq, Robert R., Young, Lauren F., Ghosh, Arnab, Singer, Natalie V., West, Mallory L., Smith, Odette M., Holland, Amanda M., Tsai, Jennifer J., Boyd, Richard L., van den Brink, Marcel R. M.

“…Endogenous thymic regeneration is a crucial function that allows for renewal of immune competence after stress, infection, or immunodepletion. However, the…”
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Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells by Hubbard-Lucey, Vanessa M., Shono, Yusuke, Maurer, Katie, West, Mallory L., Singer, Natalie V., Ziegler, Carly G.K., Lezcano, Cecilia, Motta, Ana Carolina Fragoso, Schmid, Karin, Levi, Samuel M., Murphy, George F., Liu, Chen, Winkler, Jeffrey D., Amaravadi, Ravi K., Rogler, Gerhard, Dickinson, Anne M., Holler, Ernst, van den Brink, Marcel R.M., Cadwell, Ken

“…Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with…”
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Sex steroid blockade enhances thymopoiesis by modulating Notch signaling by Velardi, Enrico, Tsai, Jennifer J, Holland, Amanda M, Wertheimer, Tobias, Yu, Vionnie W C, Zakrzewski, Johannes L, Tuckett, Andrea Z, Singer, Natalie V, West, Mallory L, Smith, Odette M, Young, Lauren F, Kreines, Fabiana M, Levy, Emily R, Boyd, Richard L, Scadden, David T, Dudakov, Jarrod A, van den Brink, Marcel R M

“…Paradoxical to its importance for generating a diverse T cell repertoire, thymic function progressively declines throughout life. This process has been at…”
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The central nervous system is a target of acute graft versus host disease in mice by Hartrampf, Steffen, Dudakov, Jarrod A., Johnson, Linda K., Smith, Odette M., Tsai, Jennifer, Singer, Natalie V., West, Mallory L., Hanash, Alan M., Albert, Michael H., Liu, Bingfang, Toth, Miklos, van den Brink, Marcel R.M.

“…Despite significant advances in prevention and management, graft versus host disease (GVHD) is still a leading complication after allogeneic hematopoietic stem…”
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Nrf2 regulates haematopoietic stem cell function by Tsai, Jennifer J., Dudakov, Jarrod A., Takahashi, Koichi, Shieh, Jae-Hung, Velardi, Enrico, Holland, Amanda M., Singer, Natalie V., West, Mallory L., Smith, Odette M., Young, Lauren F., Shono, Yusuke, Ghosh, Arnab, Hanash, Alan M., Tran, Hien T., Moore, Malcolm A. S., van den Brink, Marcel R. M.

“…Van den Brink and colleagues show that Nrf2, a regulator of the oxidative stress response, is required for several aspects of haematopoietic stem cell…”
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A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity by Shono, Yusuke, Tuckett, Andrea Z, Ouk, Samedy, Liou, Hsiou-Chi, Altan-Bonnet, Grégoire, Tsai, Jennifer J, Oyler, Jennifer E, Smith, Odette M, West, Mallory L, Singer, Natalie V, Doubrovina, Ekaterina, Pankov, Dmitry, Undhad, Chandresh V, Murphy, George F, Lezcano, Cecilia, Liu, Chen, O'Reilly, Richard J, van den Brink, Marcel R M, Zakrzewski, Johannes L

“…Preventing unfavorable GVHD without inducing broad suppression of the immune system presents a major challenge of allogeneic hematopoietic stem cell…”
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Extrathymic development of murine T cells after bone marrow transplantation by Holland, Amanda M, Zakrzewski, Johannes L, Tsai, Jennifer J, Hanash, Alan M, Dudakov, Jarrod A, Smith, Odette M, West, Mallory L, Singer, Natalie V, Brill, Jessie, Sun, Joseph C, van den Brink, Marcel R M

“…Restoring T cell competence is a significant clinical challenge in patients whose thymic function is severely compromised due to age or cytoreductive…”
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PLZF Confers Effector Functions to Donor T Cells That Preserve Graft-versus-Tumor Effects while Attenuating GVHD by GHOSH, Arnab, HOLLAND, Amanda M, TSAI, Jennifer J, JENQ, Robert R, PENACK, Olaf, HANASH, Alan M, LEZCANO, Cecilia, MURPHY, George F, CHEN LIU, SADELAIN, Michel, SAUER, Martin G, SANT'ANGELO, Derek, DOGAN, Yildirim, VAN DEN BRINK, Marcel R. M, YIM, Nury L, RAO, Uttam K, YOUNG, Lauren F, WEST, Mallory L, SINGER, Natalie V, HAE LEE, NA, Ii-Kang

“…Efforts to limit GVHD mediated by alloreactive donor T cells after allogeneic bone marrow transplantation are limited by a concomitant decrease in…”
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Sex Steroid Blockade Enhances Thymopoiesis By Modulating Notch Signaling by Velardi, Enrico, Tsai, Jennifer J, Holland, Amanda M., Singer, Natalie V, West, Mallory L, Smith, Odette M, Young, Lauren F., Kreines, Fabiana M, Levy, Emily R, Boyd, Richard, van den Brink, Marcel R.M., Dudakov, Jarrod A

“…Thymopoiesis is a complex process dependent on precise signals from the supporting thymic stromal microenvironment that orchestrates the progression of…”
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Inhibition of c-Rel Activity Prevents Graft-Versus-Host Disease without Compromising Tumor Immunity by Shono, Yusuke, Tuckett, Andrea Z, Liou, Hsiou-Chi, Altan-Bonnet, Gregoire, Tsai, Jennifer J, Smith, Odette M, West, Mallory L, Singer, Natalie V, van den Brink, Marcel R.M, Zakrzewski, Johannes L

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Age-Related Thymic Involution Triggers Intrinsic Regeneration Pathways but They Remain Ineffective for Its Renewal by Dudakov, Jarrod A, Hanash, Alan M, Singer, Natalie V, West, Mallory L, Young, Lauren F., Jenq, Robert R, Boyd, Richard L, Van Den Brink, Marcel

“…Abstract 1043 Thymopoiesis is a highly complex process involving cross-talk interactions between developing thymocytes and the supporting non-hematopoietic…”
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Autophagy GeneAtg16l1Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells by Hubbard-Lucey, van essa M, Shono, Yusuke, Maurer, Katie, West, Mallory L, Singer, Natalie V, Ziegler, Carly GK, Lezcano, Cecilia, Motta, Ana Carolina Fragoso, Schmid, Karin, Levi, Samuel M, Murphy, George F, Liu, Chen, Winkler, Jeffrey D, Amaravadi, Ravi K, Rogler, Gerhard, Dickinson, Anne M, Holler, Ernst, van  den Brink, Marcel RM, Cadwell, Ken

“…Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with…”
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Extrathymic development of murine T cells after bone marrow transplantation by Holland, Amanda M, Zakrzewski, Johannes L, Tsai, Jennifer J, Hanash, Alan M, Dudakov, Jarrod A, Smith, Odette M, West, Mallory L, Singer, Natalie V, Brill, Jessie, Sun, Joseph C, van den Brink, Marcel R.M

“…Restoring T cell competence is a significant clinical challenge in patients whose thymic function is severely compromised due to age or cytoreductive…”
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Inhibition of c-Rel Signaling: A Novel Small Molecule-Based Therapy Diminishing T Cell Alloactivation While Preserving Anti-Tumor Activity by Shono, Yusuke, Tuckett, Andrea, Liou, Hsiou-Chi, Atlan-Bonnet, Gregoire, Tsai, Jennifer J., Smith, Odette M., West, Mallory L., Singer, Natalie V., van den Brink, Marcel R.M., Zakrzewski, Johannes

“…Abstract 454 Allogeneic hematopoietic stem cell transplantation (HSCT) was initially developed as a rescue from therapy-related bone marrow failure following…”
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PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating graft-versus-host-disease by Ghosh, Arnab, Holland, Amanda M., Dogan, Yildirim, Yim, Nury L., Rao, Uttam K., Young, Lauren F., West, Mallory L., Singer, Natalie V., Lee, Hae, Na, Il-Kang, Tsai, Jennifer J., Jenq, Robert R., Penack, Olaf, Hanash, Alan M., Lezcano, Cecilia, Murphy, George, Liu, Chen, Sadelain, Michel, Sauer, Martin G., Sant’Angelo, Derek, van den Brink, Marcel R.M.

“…Efforts to limit graft-versus-host disease (GVHD) mediated by alloreactive donor T cells after allogeneic bone marrow transplantation (allo-BMT) are limited by…”
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Over-Expression of TRAIL on Donor T Cells Enhances GVT and Suppresses Gvhd Via Elimination of Alloreactive T Cells and Host APC by Ghosh, Arnab, Dogan, Yildirim, Holland, Amanda M., Smith, Odette M, Young, Lauren F., West, Mallory L, Singer, Natalie V, Jenq, Robert R, Na, Il-Kang, Penack, Olaf, Hanash, Alan M, Sauer, Martin G., Sadelain, Michel, van den Brink, Marcel R.M.

“…Abstract 817 Strategies to suppress GVHD are often associated with broader suppression of the immune system leading to a compromised GVT effect. Using…”
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The Central Nervous System Is a Target Organ of Acute Graft-Versus-Host Disease by Hartrampf, Steffen, Dudakov, Jarrod A, Johnson, Linda K, Smith, Odette M, Tsai, Jennifer J, Hanash, Alan M, Singer, Natalie V, West, Mallory L, Liu, Bing F, Toth, Miklos, van den Brink, Marcel R.M.

“…Abstract 1895 One of the major limitations of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is graft-versus-host disease (GVHD), which is a…”
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Innate Lymphoid Cell-Derived IL-22 Mediates Endogenous Thymic Repair Under the Control of IL-23 by Dudakov, Jarrod A, Hanash, Alan M, Young, Lauren F., Singer, Natalie V, West, Mallory L, Jenq, Robert R, Smith, Odette M, Holland, Amanda M, Boyd, Richard L, van den Brink, Marcel R.M.

“…Abstract 143 Despite being exquisitely sensitive to insult, the thymus is remarkably resilient in young healthy animals. Endogenous regeneration of the thymus…”
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