Search Results - "West, Kirk L."

Nuclear F-actin assembly on damaged chromatin is regulated by DYRK1A and Spir1 phosphorylation by Li, Junshi, Xiong, Nan, West, Kirk L, Leung, Manton, Ching, Yick Pang, Huang, Jun, Yuan, Jian, Yu, Cheng-Han, Leung, Justin, Huen, Michael

“…Abstract Nuclear actin-based movements support DNA double-strand break (DSB) repair. However, molecular determinants that promote filamentous actin (F-actin)…”
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Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma by Shields, Bradley D, Koss, Brian, Taylor, Erin M, Storey, Aaron J, West, Kirk L, Byrum, Stephanie D, Mackintosh, Samuel G, Edmondson, Rick, Mahmoud, Fade, Shalin, Sara C, Tackett, Alan J

“…Identifying controlling features of responsiveness to checkpoint blockade therapies is an urgent goal in oncology research. Our group and others have…”
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Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination by Kelliher, Jessica L., West, Kirk L., Gong, Qingguo, Leung, Justin W. C.

“…Histone ubiquitination plays an important role in the DNA damage response (DDR) pathway. RNF168 catalyzes H2A and H2AX ubiquitination on lysine 13/15 (K13/K15)…”
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Proteomic characterization of the arsenic response locus in S. cerevisiae by West, Kirk L., Byrum, Stephanie D., Mackintosh, Samuel G., Edmondson, Rick D., Taverna, Sean D., Tackett, Alan J.

“…Arsenic exposure is a global health problem. Millions of people encounter arsenic through contaminated drinking water, consumption, and inhalation. The arsenic…”
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LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation by West, Kirk L, Kelliher, Jessica L, Xu, Zhanzhan, An, Liwei, Reed, Megan R, Eoff, Robert L, Wang, Jiadong, Huen, Michael S Y, Leung, Justin W C

“…Abstract The tumor suppressor protein 53BP1 plays key roles in response to DNA double-strand breaks (DSBs) by serving as a master scaffold at the damaged…”
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Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin by Dong, Chao, West, Kirk L., Tan, Xin Yi, Li, Junshi, Ishibashi, Toyotaka, Yu, Cheng-han, Sy, Shirley M. H., Leung, Justin W. C., Huen, Michael S. Y.

“…DNA double-strand breaks (DSBs) trigger transient pausing of nearby transcription, an emerging ATM-dependent response that suppresses chromosomal instability…”
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DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA by Gao, Jun, Byrd, Alicia K, Zybailov, Boris L, Marecki, John C, Guderyon, Michael J, Edwards, Andrea D, Chib, Shubeena, West, Kirk L, Waldrip, Zachary J, Mackintosh, Samuel G, Gao, Zhaofeng, Putnam, Andrea A, Jankowsky, Eckhard, Raney, Kevin D

“…We identified 29 G-quadruplex binding proteins by affinity purification and quantitative LC-MS/MS. We demonstrated that the DEAD-box RNA helicases Dbp2, Ded1…”
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Loss of E-cadherin inhibits CD103 anti-tumor activity and reduces checkpoint blockade responsiveness in melanoma by Shields, Bradley D., Koss, Brian, Taylor, Erin M., Storey, Aaron J., West, Kirk L., Byrum, Stephanie D., Mackintosh, Samuel G., Edmondson, Rick, Mahmoud, Fade, Shalin, Sara C., Tackett, Alan J.

“…Identifying controlling features of responsiveness to checkpoint blockade therapies is an urgent goal in oncology research. Our group and others have…”
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