Search Results - "West, James D"

Longitudinal Analysis Casts Doubt on the Presence of Genetic Anticipation in Heritable Pulmonary Arterial Hypertension by LARKIN, Emma K, NEWMAN, John H, AUSTIN, Eric D, HEMNES, Anna R, WHEELER, Lisa, ROBBINS, Ivan M, WEST, James D, PHILLIPS, John A, HAMID, Rizwan, LOYD, James E

“…Analysis of the age of onset in heritable pulmonary arterial hypertension (HPAH) has led to the hypothesis that genetic anticipation causes younger age of…”
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Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension by West, James D, Carrier, Erica J, Bloodworth, Nathaniel C, Schroer, Alison K, Chen, Peter, Ryzhova, Larisa M, Gladson, Santhi, Shay, Sheila, Hutcheson, Joshua D, Merryman, W David

“…Serotonergic anorexigens are the primary pharmacologic risk factor associated with pulmonary arterial hypertension (PAH), and the resulting PAH is clinically…”
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Thromboxane-Prostanoid Receptor Signaling Drives Persistent Fibroblast Activation in Pulmonary Fibrosis by Suzuki, Toshio, Kropski, Jonathan A, Chen, Jingyuan, Carrier, Erica J, Chen, Xinping, Sherrill, Taylor P, Winters, Nichelle I, Camarata, Jane E, Polosukhin, Vasiliy V, Han, Wei, Rathinasabapathy, Anandharajan, Gutor, Sergey, Gulleman, Peter, Sabusap, Carleen, Banovich, Nicholas E, Tanjore, Harikrishna, Freeman, Michael L, Tada, Yuji, Young, Lisa R, Gokey, Jason J, Blackwell, Timothy S, West, James D

“…Although persistent fibroblast activation is a hallmark of idiopathic pulmonary fibrosis (IPF), mechanisms regulating persistent fibroblast activation in the…”
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Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise by West, James D, Wang, Yanyu, Morano, Kevin A

“…All cells have developed various mechanisms to respond and adapt to a variety of environmental challenges, including stresses that damage cellular proteins…”
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Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule by Trott, Amy, West, James D, Klaić, Lada, Westerheide, Sandy D, Silverman, Richard B, Morimoto, Richard I, Morano, Kevin A

“…Stress response pathways allow cells to sense and respond to environmental changes and adverse pathophysiological states. Pharmacological modulation of…”
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The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds by Wang, Yanyu, Gibney, Patrick A, West, James D, Morano, Kevin A

“…The heat shock transcription factor HSF1 governs the response to heat shock, oxidative stresses, and xenobiotics through unknown mechanisms. We demonstrate…”
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Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction by Gaskill, Christa F, Carrier, Erica J, Kropski, Jonathan A, Bloodworth, Nathaniel C, Menon, Swapna, Foronjy, Robert F, Taketo, M Mark, Hong, Charles C, Austin, Eric D, West, James D, Means, Anna L, Loyd, James E, Merryman, W David, Hemnes, Anna R, De Langhe, Stijn, Blackwell, Timothy S, Klemm, Dwight J, Majka, Susan M

“…Pulmonary vascular disease is characterized by remodeling and loss of microvessels and is typically attributed to pathological responses in vascular…”
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Bone Marrow–Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism by Bloodworth, Nathaniel C, Clark, Cynthia R, West, James D, Snider, J Caleb, Gaskill, Christa, Shay, Sheila, Scott, Christine, Bastarache, Julie, Gladson, Santhi, Moore, Christy, D’Amico, Reid, Brittain, Evan L, Tanjore, Harikrishna, Blackwell, Timothy S, Majka, Susan M, Merryman, W David

“…RATIONALE:Pulmonary arterial hypertension is a deadly disease of the pulmonary vasculature for which no disease-modifying therapies exist. Small-vessel…”
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KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models by West, James D, Austin, Eric D, Rizzi, Elise M, Yan, Ling, Tanjore, Harikrishna, Crabtree, Amber L, Moore, Christy S, Muthian, Gladson, Carrier, Erica J, Jacobson, David A, Hamid, Rizwan, Kendall, Peggy L, Majka, Susan, Rathinasabapathy, Anandharajan

“…Loss of function KCNK3 mutation is one of the gene variants driving hereditary pulmonary arterial hypertension (PAH). KCNK3 is expressed in several cell and…”
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Redox requirements for ubiquitin-like urmylation of Ahp1, a 2-Cys peroxiredoxin from yeast by Brachmann, Cindy, Kaduhr, Lars, Jüdes, André, Ravichandran, Keerthiraju Ethiraju, West, James D., Glatt, Sebastian, Schaffrath, Raffael

“…The yeast peroxiredoxin Ahp1, like related anti-oxidant enzymes in other species, undergoes urmylation, a lysine-directed conjugation to ubiquitin-like…”
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Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension by Bertero, Thomas, Lu, Yu, Annis, Sofia, Hale, Andrew, Bhat, Balkrishen, Saggar, Rajan, Saggar, Rajeev, Wallace, W Dean, Ross, David J, Vargas, Sara O, Graham, Brian B, Kumar, Rahul, Black, Stephen M, Fratz, Sohrab, Fineman, Jeffrey R, West, James D, Haley, Kathleen J, Waxman, Aaron B, Chau, B Nelson, Cottrill, Katherine A, Chan, Stephen Y

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Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension by Bryant, Andrew J, Carrick, Ryan P, McConaha, Melinda E, Jones, Brittany R, Shay, Sheila D, Moore, Christy S, Blackwell, Thomas R, Gladson, Santhi, Penner, Niki L, Burman, Ankita, Tanjore, Harikrishna, Hemnes, Anna R, Karwandyar, Ayub K, Polosukhin, Vasiliy V, Talati, Megha A, Dong, Hui-Jia, Gleaves, Linda A, Carrier, Erica J, Gaskill, Christa, Scott, Edward W, Majka, Susan M, Fessel, Joshua P, Haase, Volker H, West, James D, Blackwell, Timothy S, Lawson, William E

“…Pulmonary hypertension (PH) complicating chronic parenchymal lung disease, such as idiopathic pulmonary fibrosis, results in significant morbidity and…”
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rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling by Rathinasabapathy, Anandharajan, Bryant, Andrew J, Suzuki, Toshio, Moore, Christy, Shay, Sheila, Gladson, Santhi, West, James D, Carrier, Erica J

“…Pulmonary hypertension (PH) is a progressive cardiovascular disease, characterized by endothelial and smooth muscle dysfunction and vascular remodeling,…”
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Experimental Approaches for Investigating Disulfide-Based Redox Relays in Cells by West, James D.

“…Reversible oxidation of cysteine residues within proteins occurs naturally during normal cellular homeostasis and can increase during oxidative stress…”
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Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension by West, James D, Austin, Eric D, Gaskill, Christa, Marriott, Shennea, Baskir, Rubin, Bilousova, Ganna, Jean, Jyh-Chang, Hemnes, Anna R, Menon, Swapna, Bloodworth, Nathaniel C, Fessel, Joshua P, Kropski, Johnathan A, Irwin, David, Ware, Lorraine B, Wheeler, Lisa, Hong, Charles C, Meyrick, Barbara, Loyd, James E, Bowman, Aaron B, Ess, Kevin C, Klemm, Dwight J, Young, Pampee P, Merryman, W David, Kotton, Darrell, Majka, Susan M

“…Understanding differences in gene expression that increase risk for pulmonary arterial hypertension (PAH) is essential to understanding the molecular basis for…”
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Myeloid-Derived Suppressor Cells and Pulmonary Hypertension by Bryant, Andrew J, Mehrad, Borna, Brusko, Todd M, West, James D, Moldawer, Lyle L

“…Myeloid⁻derived suppressor cells (MDSCs) comprised a heterogeneous subset of bone marrow⁻derived myeloid cells, best studied in cancer research, that are…”
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Pulmonary Vascular Platform Models the Effects of Flow and Pressure on Endothelial Dysfunction in BMPR2 Associated Pulmonary Arterial Hypertension by D'Amico, Reid W, Faley, Shannon, Shim, Ha-Na, Prosser, Joanna R, Agrawal, Vineet, Bellan, Leon M, West, James D

“…Endothelial dysfunction is a known consequence of bone morphogenetic protein type II receptor ( ) mutations seen in pulmonary arterial hypertension (PAH)…”
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l‐Carnitine therapy improves right heart dysfunction through Cpt1‐dependent fatty acid oxidation by Agrawal, Vineet, Hemnes, Anna R., Shelburne, Nicholas J., Fortune, Niki, Fuentes, Julio L., Colvin, Dan, Calcutt, Marion W., Talati, Megha, Poovey, Emily, West, James D., Brittain, Evan L.

“…Pulmonary arterial hypertension (PAH) is a fatal vasculopathy that ultimately leads to elevated pulmonary pressure and death by right ventricular (RV) failure,…”
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Monitoring uterine contractility in mice using a transcervical intrauterine pressure catheter by Robuck, Michael F, O’Brien, Christine M, Knapp, Kelsi M, Shay, Sheila D, West, James D, Newton, J M, Slaughter, James C, Paria, Bibhash C, Reese, Jeff, Herington, Jennifer L

“…In mouse models used to study parturition or pre-clinical therapeutic testing, measurement of uterine contractions is limited to either ex vivo isometric…”
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Urm1, not quite a ubiquitin-like modifier? by Kaduhr, Lars, Brachmann, Cindy, Ravichandran, Keerthiraju Ethiraju, West, James D., Glatt, Sebastian, Schaffrath, Raffael

“…Ubiquitin related modifier 1 (Urm1) is a unique eukaryotic member of the ubiquitin-fold (UbF) protein family and conserved from yeast to humans. Urm1 is…”
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