Search Results - "West, F G"

A Mild Method for the Generation and Interception of 1,2-Cycloheptadienes with 1,3-Dipoles by Almehmadi, Yaseen A, West, F. G

“…1,2-Cycloheptadiene is a strained, transient species that has been underutilized as a synthetic building block. Seven-membered cyclic allenes are mostly known…”
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Medium-Sized Cyclic Ethers via Stevens [1,2]-Shift of Mixed Monothioacetal-Derived Sulfonium Ylides: Application to Formal Synthesis of (+)-Laurencin by Lin, Rongrong, Cao, Liya, West, F. G

“…A novel approach to medium-sized cyclic ethers was devised using a Stevens [1,2]-shift of a sulfonium ylide derived from a readily accessible six-membered…”
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Strain-Activated Diels–Alder Trapping of 1,2-Cyclohexadienes: Intramolecular Capture by Pendent Furans by Lofstrand, Verner A, McIntosh, Kyle C, Almehmadi, Yaseen A, West, F. G

“…Intramolecular [4 + 2] cycloaddition reactions of substituted 1,2-cyclohexadienes with pendent furans enables the synthesis of complex tetracyclic scaffolds in…”
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Expedient Route to the Tigliane-Daphnane Skeleton via Oxonium Ylide [1,2]-Shift by Stewart, Craig, McDonald, Robert, West, F. G

“…A short, stereoselective approach to the fused tricyclic carbon skeleton found in the tigliane and daphnane classes of diterpene natural products is described…”
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Oxidation‐Initiated Cyclizations of Pentadienyl Ethers: An Alternative Entry to the Nazarov Reaction by Fradette, Ryan J., Kang, Minkyu, West, F. G.

“…Oxidation‐initiated Nazarov reactions of 1,4‐pentadien‐3‐yl ethers take place in the presence of DDQ. Termination by regioselective elimination preserves both…”
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Nazarov Reactions of Vinyl Cyclopropylamines: An Approach to the Imino-Nazarov Problem by Bonderoff, Sara A, Grant, Tina N, West, F. G, Tremblay, Martin

“…Dichlorocyclopropanation of 2-amino-1,3-dienes affords 1-alkenyl-1-amino-2,2-dichlorocyclopropanes which undergo silver-assisted 2-π electrocyclic opening to…”
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Formal Homologous Aldol Reactions: Interrupting the Nazarov Cyclization via Carboalkoxylation of Alkynes by Wu, Yen-Ku, West, F. G.

“…Reactions between 1,4-pentadien-3-ones and aryl acetylenes in the presence of BF3·OEt2 furnish α-phenacyl cyclopentanones via a domino…”
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One‐Pot Generation of Bicyclo[3.1.0]hexanols and Cyclohexanones by Double Interrupted Nazarov Reactions by Gelozia, Shorena, Kwon, Yonghoon, McDonald, Robert, West, F. G.

“…Organoaluminum‐mediated double interrupted Nazarov cyclization to access bicyclo[3.1.0]hexanols via nucleophilic methyl attack followed by Simmons–Smith‐type…”
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Experimental and Computational Studies on Interrupted Nazarov Reactions: Exploration of Umpolung Reactivity at the α‑Carbon of Cyclopentanones by Wu, Yen-Ku, Dunbar, Christine R, McDonald, Robert, Ferguson, Michael J, West, F. G

“…A set of densely substituted, α-functionalized cyclopentanones can be generated by a two-component, domino reaction sequence entailing the Nazarov…”
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Interrupting the Nazarov Cyclization with Bromine by Schatz, Devon J, Kwon, Yonghoon, Scully, Thomas W, West, F. G

“…The generation of dibrominated cyclopentenones via an interrupted Nazarov cyclization is reported. The installation of two bromine atoms occurs at the α and α′…”
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Preparation and Synthetic Applications of Azetidines by G. West, F., M. Bott, Tina

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Domino Electrocyclization/Azide-Capture/Schmidt Rearrangement of Dienones:  One-Step Synthesis of Dihydropyridones from Simple Building Blocks by Song, Dong, Rostami, Ali, West, F. G

“…Simple 1,4-dien-3-ones undergo Lewis acid-catalyzed Nazarov electrocyclization and intermolecular trapping by various azides to furnish…”
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Dual Catalytic Synthesis of Antiviral Compounds Based on Metallocarbene–Azide Cascade Chemistry by Atienza, Bren Jordan P, Jensen, Lionel D, Noton, Sarah L, Ansalem, Anil Kumar Victoria, Hobman, Tom, Fearns, Rachel, Marchant, David J, West, F. G

“…Aryl azides trap ortho-metallocarbene intermediates to generate indolenones possessing a reactive C-acylimine moiety, which can react with added indole…”
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Cyclization of Cross-Conjugated Trienes: The Vinylogous Nazarov Reaction by Rieder, Curtis J, Winberg, Karl J, West, F. G

“…Cross-conjugated trienoates can be readily prepared from 1,4-pentadien-3-one precursors via a 2-step process: 1,2-addition of lithiated ethynyl ethyl ether…”
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Intermolecular [3 + 3]-Cycloadditions of Azides with the Nazarov Intermediate by Scadeng, Owen, Ferguson, Michael J, West, F. G

“…Tetrasubstituted 1,4-dien-3-ones undergo Nazarov cyclization at low temperature, followed by reaction with organic azides via an apparent [3 + 3]-cycloaddition…”
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Homologous Mukaiyama Reactions via Trapping of the Nazarov Intermediate with Silyloxyalkenes by Wu, Yen-Ku, McDonald, Robert, West, F. G

“…Treatment of 1,4-pentadien-3-ones and silyloxyalkenes with BF3·OEt2 at room temperature or lower initiates a domino process consisting of sequential 4π…”
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Olefination of α,α′-Divinyl Ketones through Catalytic Meyer−Schuster Rearrangement by Rieder, Curtis J, Winberg, Karl J, West, F. G

“…The direct olefination of 1,4-dien-3-ones remains a synthetic challenge. A two-step protocol, employing acetylide addition followed by catalytic Meyer−Schuster…”
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Brønsted Acid-Mediated Nazarov Cyclization of Vinylallenes by Wu, Yen-Ku, West, F. G

“…Treatment of siloxy enynes with base leads to the corresponding vinylsiloxyallenes which undergo Nazarov cyclization in the presence of trifluoroacetic acid to…”
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Reactivity and Stereoselectivity of 6π and Nazarov Electrocyclizations of Bridged Bicyclic Trienes and Divinyl Ketones by Patel, Ashay, West, F. G, Houk, K. N

“…The 6π electrocyclizations and Nazarov cyclizations of a series of bridged bicyclic substrates were modeled with the M06-2X density functional and the…”
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Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol Analogs by Rana, Natasha, Aziz, Marwa A, Oraby, Ahmed K, Wuest, Melinda, Dufour, Jennifer, Abouzid, Khaled A M, Wuest, Frank, West, F G

“…Deregulation and changes in energy metabolism are emergent and important biomarkers of cancer cells. The uptake of hexoses in cancer cells is mediated by a…”
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