Search Results - "West, Erin E."

Chronic Virus Infection Enforces Demethylation of the Locus that Encodes PD-1 in Antigen-Specific CD8 + T Cells by Youngblood, Ben, Oestreich, Kenneth J., Ha, Sang-Jun, Duraiswamy, Jaikumar, Akondy, Rama S., West, Erin E., Wei, Zhengyu, Lu, Peiyuan, Austin, James W., Riley, James L., Boss, Jeremy M., Ahmed, Rafi

“…Functionally exhausted T cells have high expression of the PD-1 inhibitory receptor, and therapies that block PD-1 signaling show promise for resolving chronic…”
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Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells by Chauss, Daniel, Freiwald, Tilo, McGregor, Reuben, Yan, Bingyu, Wang, Luopin, Nova-Lamperti, Estefania, Kumar, Dhaneshwar, Zhang, Zonghao, Teague, Heather, West, Erin E., Vannella, Kevin M., Ramos-Benitez, Marcos J., Bibby, Jack, Kelly, Audrey, Malik, Amna, Freeman, Alexandra F., Schwartz, Daniella M., Portilla, Didier, Chertow, Daniel S., John, Susan, Lavender, Paul, Kemper, Claudia, Lombardi, Giovanna, Mehta, Nehal N., Cooper, Nichola, Lionakis, Michail S., Laurence, Arian, Kazemian, Majid, Afzali, Behdad

“…The molecular mechanisms governing orderly shutdown and retraction of CD4 + type 1 helper T (T H 1) cell responses remain poorly understood. Here we show that…”
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Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection by Jin, Hyun-Tak, Anderson, Ana C., Tan, Wendy G., West, Erin E., Ha, Sang-Jun, Araki, Koichi, Freeman, Gordon J., Kuchroo, Vijay K., Ahmed, Rafi

“…Inhibitory receptors play a crucial role in regulating CD8 T-cell function during chronic viral infection. T-cell Ig- and mucin-domain–containing molecule–3…”
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The Cytokines IL-21 and GM-CSF Have Opposing Regulatory Roles in the Apoptosis of Conventional Dendritic Cells by Wan, Chi-Keung, Oh, Jangsuk, Li, Peng, West, Erin E., Wong, Elizabeth A., Andraski, Allison B., Spolski, Rosanne, Yu, Zu-Xi, He, Jianping, Kelsall, Brian L., Leonard, Warren J.

“…Interleukin-21 (IL-21) has broad actions on T and B cells, but its actions in innate immunity are poorly understood. Here we show that IL-21 induced apoptosis…”
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Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression by Liao, Wei, Spolski, Rosanne, Li, Peng, Du, Ning, West, Erin E., Ren, Min, Mitra, Suman, Leonard, Warren J.

“…Interleukin 9 (IL-9) is a γ c-family cytokine that is highly produced by T-helper 9 (Th9) cells and regulates a range of immune responses, including allergic…”
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Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism by Arbore, Giuseppina, West, Erin E., Rahman, Jubayer, Le Friec, Gaelle, Niyonzima, Nathalie, Pirooznia, Mehdi, Tunc, Ilker, Pavlidis, Polychronis, Powell, Nicholas, Li, Yuesheng, Liu, Poching, Servais, Aude, Couzi, Lionel, Fremeaux-Bacchi, Veronique, Placais, Leo, Ferraro, Alastair, Walsh, Patrick R., Kavanagh, David, Afzali, Behdad, Lavender, Paul, Lachmann, Helen J., Kemper, Claudia

“…The induction of human CD4 + Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4 + T cell-intrinsic NLRP3…”
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Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load by West, Erin E., Youngblood, Ben, Tan, Wendy G., Jin, Hyun-Tak, Araki, Koichi, Alexe, Gabriela, Konieczny, Bogumila T., Calpe, Silvia, Freeman, Gordon J., Terhorst, Cox, Haining, W. Nicholas, Ahmed, Rafi

“…To design successful vaccines for chronic diseases, an understanding of memory CD8+ T cell responses to persistent antigen restimulation is critical. However,…”
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EGR2 is critical for peripheral naïve T-cell differentiation and the T-cell response to influenza by Du, Ning, Kwon, Hyokjoon, Li, Peng, West, Erin E., Oh, Jangsuk, Liao, Wei, Yu, Zuxi, Ren, Min, Leonard, Warren J.

“…Early growth response 2 (EGR2) transcription factor negatively regulates T-cell activation, in contrast to the positive regulation of this process by EGR1…”
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Comparative Analysis of Simian Immunodeficiency Virus Gag-Specific Effector and Memory CD8+ T Cells Induced by Different Adenovirus Vectors by Tan, Wendy G, Jin, Hyun-Tak, West, Erin E, Penaloza-MacMaster, Pablo, Wieland, Andreas, Zilliox, Michael J, McElrath, M Juliana, Barouch, Dan H, Ahmed, Rafi

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Complosome — the intracellular complement system by West, Erin E., Kemper, Claudia

“…The complement system is a recognized pillar of host defence against infection and noxious self-derived antigens. Complement is traditionally known as a…”
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Complement and human T cell metabolism: Location, location, location by West, Erin E., Kunz, Natalia, Kemper, Claudia

“…The complement system represents one of the evolutionary oldest arms of our immune system and is commonly recognized as a liver‐derived and serum‐active system…”
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Thymic stromal lymphopoietin limits primary and recall CD8 + T-cell anti-viral responses by Ebina-Shibuya, Risa, West, Erin E, Spolski, Rosanne, Li, Peng, Oh, Jangsuk, Kazemian, Majid, Gromer, Daniel, Swanson, Phillip, Du, Ning, McGavern, Dorian B, Leonard, Warren J

“…Thymic stromal lymphopoietin (TSLP) is a cytokine that acts directly on CD4 T cells and dendritic cells to promote progression of asthma, atopic dermatitis,…”
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Complement and the Regulation of T Cell Responses by West, Erin E, Kolev, Martin, Kemper, Claudia

“…The complement system is an evolutionarily ancient key component of innate immunity required for the detection and removal of invading pathogens. It was…”
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IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus by Spolski, Rosanne, West, Erin E, Li, Peng, Veenbergen, Sharon, Yung, Sunny, Kazemian, Majid, Oh, Jangsuk, Yu, Zu-Xi, Freeman, Alexandra F, Holland, Stephen M, Murphy, Philip M, Leonard, Warren J

“…Methicillin-resistant (MRSA) is a major hospital- and community-acquired pathogen, but the mechanisms underlying host-defense to MRSA remain poorly understood…”
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Intracellular C1q – an unexpected player in neuronal proteostasis by West, Erin E., Kemper, Claudia

“…Extrahepatic, cell-autonomous, and/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological…”
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Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency) by Lenherr, Nina, Christodoulou, John, Duley, John, Dobritzsch, Doreen, Fairbanks, Lynette, Datta, Alexandre N., Filges, Isabel, Gürtler, Nicolas, Roelofsen, Jeroen, van Kuilenburg, André B.P., Kemper, Claudia, West, Erin E., Szinnai, Gabor, Huemer, Martina

“…Arts syndrome or phosphoribosyl-pyrophosphate-synthetase-1 (PRPS1) deficiency is caused by loss-of-function mutations in the PRPS1 gene (Xq22.3). PRPS1 is an…”
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Complement in human disease: approved and up-and-coming therapeutics by West, Erin E, Woodruff, Trent, Fremeaux-Bacchi, Veronique, Kemper, Claudia

“…The complement system is recognised as a protector against blood-borne pathogens and a controller of immune system and tissue homoeostasis. However,…”
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Effector CD8 T cells dedifferentiate into long-lived memory cells by Youngblood, Ben, Hale, J. Scott, Kissick, Haydn T., Ahn, Eunseon, Xu, Xiaojin, Wieland, Andreas, Araki, Koichi, West, Erin E., Ghoneim, Hazem E., Fan, Yiping, Dogra, Pranay, Davis, Carl W., Konieczny, Bogumila T., Antia, Rustom, Cheng, Xiaodong, Ahmed, Rafi

“…DNA methylation profiling of virus-specific T cells during acute viral infection in mice provides evidence that a fate-permissive subset of effector CD8 T…”
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Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation by Freeley, Simon, Cardone, John, Günther, Sira C, West, Erin E, Reinheckel, Thomas, Watts, Colin, Kemper, Claudia, Kolev, Martin V

“…Autocrine activation of the complement receptors C3aR and CD46 by complement activation components C3a and C3b produced through C3 cleavage by the protease…”
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Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity by Lariviere, William R, Wilson, Sonya G, Laughlin, Tinna M, Kokayeff, Anna, West, Erin E, Adhikari, Seetal M, Wan, You, Mogil, Jeffrey S

“…We and others have previously demonstrated that nociception in the mouse is heritable. A genetic correlation analysis of 12 common measures of nociception…”
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