Search Results - "West, E.J."

A Pilot Study to Assess Whether Glucagon-Like Peptide-1 Protects the Heart From Ischemic Dysfunction and Attenuates Stunning After Coronary Balloon Occlusion in Humans by Read, Philip A, Hoole, Stephen P, White, Paul A, Khan, Fakhar Z, OʼSullivan, Michael, West, Nick E.J, Dutka, David P

“…BACKGROUND—The incretin hormone glucagon-like peptide-1 (GLP-1) has been shown to have cardioprotective properties in animal models of ischemia and infarction…”
Get full text

Cardioprotection for percutaneous coronary intervention — Reperfusion quality as well as quantity by Giblett, Joel P, West, Nick E.J, Hoole, Stephen P

“…Abstract Ischaemia−reperfusion (IR) injury is an important cause of myocardial damage during percutaneous coronary intervention (PCI). There are few therapies…”
Get full text

Lymphokine‐activated killer and dendritic cell carriage enhances oncolytic reovirus therapy for ovarian cancer by overcoming antibody neutralization in ascites by Jennings, V.A., Ilett, E.J., Scott, K.J., West, E.J., Vile, R., Pandha, H., Harrington, K., Young, A., Hall, G.D., Coffey, M., Selby, P., Errington‐Mais, F., Melcher, A.A.

“…Reovirus is an oncolytic virus (OV), which acts by both direct tumor cell killing and priming of antitumor immunity. A major obstacle for effective oncolytic…”
Get full text

Nitric Oxide Modulates Superoxide Release and Peroxynitrite Formation in Human Blood Vessels by Guzik, Tomasz J, West, Nick E.J, Pillai, Ravi, Taggart, David P, Channon, Keith M

“…Nitric oxide and superoxide have important roles as vascular signaling molecules. Nitric oxide (NO) reacts rapidly with superoxide, producing peroxynitrite…”
Get full text

Clinical and angiographic predictors of restenosis after stent deployment in diabetic patients by WEST, Nick E. J, RUYGROK, Peter N, DISCO, Clemens M. C, WEBSTER, Mark W. I, LINDEBOOM, Wietze K, O'NEILL, William W, MERCADO, Nestor F, SERRUYS, Patrick W

“…Restenosis and consequent adverse cardiac events are increased in diabetics undergoing percutaneous coronary intervention. Use of intracoronary stents may…”
Get full text

Direct Comparison of Virtual-Histology Intravascular Ultrasound and Optical Coherence Tomography Imaging for Identification of Thin-Cap Fibroatheroma by Brown, Adam J, Obaid, Daniel R, Costopoulos, Charis, Parker, Richard A, Calvert, Patrick A, Teng, Zhongzhao, Hoole, Stephen P, West, Nick E J, Goddard, Martin, Bennett, Martin R

“…Although rupture of thin-cap fibroatheroma (TCFA) underlies most myocardial infarctions, reliable TCFA identification remains challenging. Virtual-histology…”
Get full text

Optical coherence tomography imaging of coronary atherosclerosis is affected by intraobserver and interobserver variability by Brown, Adam J, Jaworski, Catherine, Corrigan, Joseph P, de Silva, Ramesh, Bennett, Martin R, Mahmoudi, Michael, Hoole, Stephen P, West, Nick E.J

“…AIMSOptical coherence tomography (OCT) has emerged as a novel imaging modality that allows plaque classification through identification of features including…”
Get full text

Expansion and malapposition characteristics after bioresorbable vascular scaffold implantation by Brown, Adam J., McCormick, Liam M., Braganza, Denise M., Bennett, Martin R., Hoole, Stephen P., West, Nick E.J.

“…Objectives This study sought to investigate the postdeployment expansion and malapposition characteristics of the bioresorbable vascular scaffold (BVS) in…”
Get full text

Impact of post‐procedural minimal stent area on 2‐year clinical outcomes in the SYNTAX II trial by Katagiri, Yuki, De Maria, Giovanni Luigi, Kogame, Norihiro, Chichareon, Ply, Takahashi, Kuniaki, Chang, Chun Chin, Modolo, Rodrigo, Walsh, Simon, Sabate, Manel, Davies, Justin, Lesiak, Maciej, Moreno, Raul, Cruz‐Gonzalez, Ignacio, West, Nick E.J., Piek, Jan J., Wykrzykowska, Joanna J., Farooq, Vasim, Escaned, Javier, Banning, Adrian P., Onuma, Yoshinobu, Serruys, Patrick W.

“…Objectives To investigate the impact of minimal stent area (MSA) evaluated by post‐procedural intravascular ultrasound (IVUS) on clinical outcomes after…”
Get full text

Effectiveness and Safety of Optical Coherence Tomography-Guided PCI in Indian Patients With Complex Lesions: A Multicenter, Prospective Registry by Chandra, Praveen, Sethuraman, Selvamani, Roy, Sanjeeb, Mohanty, Arun, Parikh, Keyur, Charantharalyil Gopalan, Bahuleyan, Sahoo, Prasant Kumar, Kasturi, Sridhar, Shah, Vijay Trambaklal, Kumar, Viveka, Pinto, Brian, Rath, Pratap Chandra, Yerramareddy, Vijayachandra Reddy, Davidson, Deepak, Navasundi, Girish B., Subban, Vijayakumar, Livingston, Nandhini, Preethi Rajaraman, Deva, Narang, Manish, West, Nick E.J., Mullasari, Ajit

“…Optical coherence tomography (OCT) is reported to be a feasible and safe imaging modality for the guidance of percutaneous coronary intervention (PCI) of…”
Get full text

Percutaneous Sampling of Local Biomolecule Gradients Across Coronary Artery Atherosclerotic Plaques by West, Nick E.J., MD, Corrigan, Joseph P., MEng, Owen, Richard H.G., PhD, Hoole, Stephen P., DM, Brown, Adam J., PhD, Blatcher, Stephen, PhD, Newby, Andrew C., PhD

“…Visual Abstract…”
Get full text

Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans by Yu, Emma, Calvert, Patrick A, Mercer, John R, Harrison, James, Baker, Lauren, Figg, Nichola L, Kumar, Sheetal, Wang, Julie C, Hurst, Liam A, Obaid, Daniel R, Logan, Angela, West, Nick E.J, Clarke, Murray C.H, Vidal-Puig, Antonio, Murphy, Michael P, Bennett, Martin R

“…BACKGROUND—Mitochondrial DNA (mtDNA) damage occurs in both circulating cells and the vessel wall in human atherosclerosis. However, it is unclear whether mtDNA…”
Get full text

Viral warfare! Front-line defence and arming the immune system against cancer using oncolytic vaccinia and other viruses by Dave, R.V, Jebar, A.H.S, Jennings, V.A, Adair, R.A, West, E.J, Errington-Mais, F, Toogood, G.J, Melcher, A.A

“…Abstract Background Despite mankind's many achievements, we are yet to find a cure for cancer. We are now approaching a new era which recognises the promise of…”
Get full text

Remote Ischemic Preconditioning Improves Outcome at 6 Years After Elective Percutaneous Coronary Intervention: The CRISP Stent Trial Long-term Follow-up by Davies, William R, Brown, Adam J, Watson, William, McCormick, Liam M, West, Nick E.J, Dutka, David P, Hoole, Stephen P

“…BACKGROUND—Postprocedural myocardial infarction (type 4a) has been shown to be an adverse prognostic indicator after elective percutaneous coronary…”
Get full text

Nitric oxide synthase (nNOS) gene transfer modifies venous bypass graft remodeling : Effects on vascular smooth muscle cell differentiation and superoxide production by WEST, Nick E. J, HUSHENG QIAN, GUZIK, Tomasz J, BLACK, Edward, SHIJIE CAI, GEORGE, Samuel E, CHANNON, Keith M

“…Pathological vascular remodeling in venous bypass grafts (VGs) results in smooth muscle cell (SMC) intimal hyperplasia and provides the substrate for…”
Get full text

Novel bioabsorbable polymer and polymer-free metallic drug-eluting stents by Nogic, Jason, McCormick, Liam M., Francis, Rohin, Nerlekar, Nitesh, Jaworski, Catherine, West, Nick E.J., Brown, Adam J.

“…•Safety concerns remain with current-generation drug-eluting stents.•Durable polymers have been implicated in drug-eluting stent failure.•Novel manufacturing…”
Get full text

Prognostic impact of fractional flow reserve measurements in patients with acute coronary syndromes: a subanalysis of the FLORIDA study by Gerhardt, Teresa, Stähli, Barbara E., Rudolph, Tanja K., Lutz, Matthias, Schatz, Anne-Sophie, Zanders, Lukas, Schubert, Tino, Stueve, Magnus, West, Nick E. J., Boone, Els, Landmesser, Ulf, Leistner, David M.

“…Randomized trials suggest benefits for fractional flow reserve (FFR)-guided vs. angiography-guided treatment strategies in well-defined and selected patient…”
Get full text

Pre-Treatment With Glucagon-Like Peptide-1 Protects Against Ischemic Left Ventricular Dysfunction and Stunning Without a Detected Difference in Myocardial Substrate Utilization by McCormick, Liam M., MBBS, Hoole, Stephen P., MA, DM, White, Paul A., PhD, Read, Philip A., MA, MD, Axell, Richard G., MSc, Clarke, Sophie J., BSc, O’Sullivan, Michael, PhD, West, Nick E.J., MA, MD, Dutka, David P., MA, DM

“…Abstract Objectives This study sought to determine whether pre-treatment with intravenous glucagon-like peptide-1 (GLP-1)(7-36) amide could alter myocardial…”
Get full text

Leukocyte Telomere Length Is Associated With High-Risk Plaques on Virtual Histology Intravascular Ultrasound and Increased Proinflammatory Activity by Calvert, Patrick A, Liew, Tze-Vun, Gorenne, Isabelle, Clarke, Murray, Costopoulos, Charis, Obaid, Daniel R, OʼSullivan, Michael, Shapiro, Leonard M, McNab, Duncan C, Densem, Cameron G, Schofield, Peter M, Braganza, Denise, Clarke, Sarah C, Ray, Kausik K, West, Nick E.J, Bennett, Martin R

“…OBJECTIVE—Leukocyte telomere length (LTL), a marker of cellular senescence, is inversely associated with cardiovascular events. However, whether LTL reflects…”
Get full text

Diastolic Backward-Traveling Decompression (Suction) Wave Correlates With Simultaneously Acquired Indices of Diastolic Function and Is Reduced in Left Ventricular Stunning by Ladwiniec, Andrew, White, Paul A, Nijjer, Sukhjinder S, O’Sullivan, Michael, West, Nick E.J, Davies, Justin E, Hoole, Stephen P

“…BACKGROUND—Wave intensity analysis can distinguish proximal (propulsion) and distal (suction) influences on coronary blood flow and is purported to reflect…”
Get full text