Search Results - "West, C M"

Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene by Buffa, F M, Harris, A L, West, C M, Miller, C J

“…Background: There is a need to develop robust and clinically applicable gene expression signatures. Hypoxia is a key factor promoting solid tumour progression…”
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Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma by Oguejiofor, K, Hall, J, Slater, C, Betts, G, Hall, G, Slevin, N, Dovedi, S, Stern, P L, West, C M L

“…Background: Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than those with…”
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Gene Expression Signatures as Biomarkers of Tumour Hypoxia by Harris, B.H.L, Barberis, A, West, C.M.L, Buffa, F.M

“…Abstract Hypoxia is a feature of most solid tumours and is associated with a poor prognosis. The hypoxic environment can reduce the efficacy of radiotherapy…”
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Head and neck cancer—Part 1: Epidemiology, presentation, and prevention by Mehanna, H, Paleri, V, West, C M L, Nutting, C

“…SUMMARY POINTS The incidence of head and neck cancer is relatively low in developed countries and highest in South East Asia The main risk factors are smoking…”
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Expression of hypoxia-inducible factor-1α predicts benefit from hypoxia modification in invasive bladder cancer by Hunter, B A, Eustace, A, Irlam, J J, Valentine, H R, Denley, H, Oguejiofor, K K, Swindell, R, Hoskin, P J, Choudhury, A, West, C M

“…Background: The addition of carbogen and nicotinamide (CON) to radiotherapy (RT) improves overall survival in invasive bladder cancer. We explored whether…”
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Tracking gastrointestinal transit of solids in aged rats as pharmacological models of chronic dysmotility by Dalziel, J. E., Young, W., Bercik, P., Spencer, N. J., Ryan, L. J., Dunstan, K. E., Lloyd‐West, C. M., Gopal, P. K., Haggarty, N. W., Roy, N. C.

“…Background Dysmotility in the gastrointestinal (GI) tract often leads to impaired transit of luminal contents leading to symptoms of diarrhea or constipation…”
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Expression of hypoxia-inducible factor 1α in thyroid carcinomas by Burrows, N, Resch, J, Cowen, R L, von Wasielewski, R, Hoang-Vu, C, West, C M, Williams, K J, Brabant, G

“…Hypoxia-inducible factor 1α (HIF-1α) is upregulated by hypoxia and oncogenic signalling in many solid tumours. Its regulation and function in thyroid…”
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Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix by Donaldson, S B, Buckley, D L, O'Connor, J P, Davidson, S E, Carrington, B M, Jones, A P, West, C M L

“…Background: There is a need for simple imaging parameters capable of predicting therapeutic outcome. Methods: This retrospective study analysed 50 patients…”
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Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples by Hall, J S, Leong, H S, Armenoult, L S C, Newton, G E, Valentine, H R, Irlam, J J, Möller-Levet, C, Sikand, K A, Pepper, S D, Miller, C J, West, C M L

“…Background: Degradation and chemical modification of RNA in formalin-fixed paraffin-embedded (FFPE) samples hamper their use in expression profiling studies…”
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Chromosomal radiosensitivity as a marker of predisposition to common cancers? by BARIA, K, WARREN, C, ROBERTS, S. A, WEST, C. M, SCOTT, D

“…We previously found that 40% of breast cancer patients showed enhanced sensitivity to X-ray induced chromosome damage in G(2)lymphocytes and suggested that…”
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Is the hypoxia-inducible factor pathway important in gastric cancer? by Griffiths, E.A., Pritchard, S.A., Welch, I.M., Price, P.M., West, C.M.

“…Tumour hypoxia is well recognised in oncology to be a key factor resulting in treatment resistance and poor prognosis. Hypoxia leads to the expression of a…”
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Investigation of the epithelial to mesenchymal transition markers S100A4, vimentin and Snail1 in gastroesophageal junction tumors by Mirza, A., Foster, L., Valentine, H., Welch, I., West, C M., Pritchard, S.

“…Summary Epithelial to mesenchymal transition (EMT) promotes tumor progression and invasion. As no study has focused on gastroesophageal junction (GEJ) tumors,…”
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Hypoxia in head and neck cancer by ISA, A. Y, WARD, T. H, WEST, C. M. L, SLEVIN, N. J, HOMER, J. J

“…A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the…”
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Epidermal growth factor receptor-targeted therapy by WEST, C. M, JOSEPH, L, BHANA, S

“…High epidermal growth factor receptor (EGFR) expression is a feature of human tumours and is an adverse prognostic factor for radiotherapy outcome. High…”
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Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix by LONCASTER, J. A, COOPER, R. A, LOGUE, J. P, DAVIDSON, S. E, HUNTER, R. D, WEST, C. M. L

“…The aim of the study was to evaluate VEGF expression in tumour biopsies as a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix. A…”
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Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis by Griffiths, E A, Pritchard, S A, McGrath, S M, Valentine, H R, Price, P M, Welch, I M, West, C M L

“…The study investigated hypoxia-associated markers (HIF-2 α , Epo, Epo-R, Glut-1 and VEGF) along with Ki-67 in a gastric carcinogenesis model, and the…”
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Tumour Hypoxia by West, C.M., Slevin, F.

“…•Oxygen fixes DNA damage by free radicals and cells are 2–3 times more radioresistant to sparsely ionising radiation when irradiated in the absence of…”
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Evolutionary and functional implications of the complex glycosylation of Skp1, a cytoplasmic/nuclear glycoprotein associated with polyubiquitination by West, C. M

“…Protein degradation is regulatory for the cell cycle, signal transduction and gene transcription. A critical step is the selective marking of the target…”
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Head and neck cancer—Part 2: Treatment and prognostic factors by Mehanna, H, West, C M L, Nutting, C, Paleri, V

“…SUMMARY POINTS The main prognostic factors are stage, site of disease, and comorbidities Treatment decisions should involve a multidisciplinary team of health…”
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Time to Rethink Commercialisation: Spin out or Lose out? by Irlam, J., West, C.M.L.

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