Search Results - "West, Anthony P."

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies by Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.

“…The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding…”
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Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy by West, Anthony P., Scharf, Louise, Scheid, Johannes F., Klein, Florian, Bjorkman, Pamela J., Nussenzweig, Michel C.

“…Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when…”
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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies by Barnes, Christopher O., West, Anthony P., Huey-Tubman, Kathryn E., Hoffmann, Magnus A.G., Sharaf, Naima G., Hoffman, Pauline R., Koranda, Nicholas, Gristick, Harry B., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. Cetrulo, Finkin, Shlomo, Hägglöf, Thomas, Hurley, Arlene, Millard, Katrina G., Weisblum, Yiska, Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Caskey, Marina, Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal…”
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Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120 by West, Anthony P, Diskin, Ron, Nussenzweig, Michel C, Bjorkman, Pamela J

“…A large number of anti–HIV-1 antibodies targeting the CD4-binding site (CD4bs) on the envelope glycoprotein gp120 have recently been reported. These…”
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Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 by Caskey, Marina, Klein, Florian, Lorenzi, Julio C. C., Seaman, Michael S., West, Anthony P., Buckley, Noreen, Kremer, Gisela, Nogueira, Lilian, Braunschweig, Malte, Scheid, Johannes F., Horwitz, Joshua A., Shimeliovich, Irina, Ben-Avraham, Sivan, Witmer-Pack, Maggi, Platten, Martin, Lehmann, Clara, Burke, Leah A., Hawthorne, Thomas, Gorelick, Robert J., Walker, Bruce D., Keler, Tibor, Gulick, Roy M., Fätkenheuer, Gerd, Schlesinger, Sarah J., Nussenzweig, Michel C.

“…A phase I study of passive immunization with a CD4 binding-site-directed broadly neutralizing antibody shows that it transiently reduces HIV-1 viral loads in…”
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Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico by Robbiani, Davide F., Bozzacco, Leonia, Keeffe, Jennifer R., Khouri, Ricardo, Olsen, Priscilla C., Gazumyan, Anna, Schaefer-Babajew, Dennis, Avila-Rios, Santiago, Nogueira, Lilian, Patel, Roshni, Azzopardi, Stephanie A., Uhl, Lion F.K., Saeed, Mohsan, Sevilla-Reyes, Edgar E., Agudelo, Marianna, Yao, Kai-Hui, Golijanin, Jovana, Gristick, Harry B., Lee, Yu E., Hurley, Arlene, Caskey, Marina, Pai, Joy, Oliveira, Thiago, Wunder, Elsio A., Sacramento, Gielson, Nery, Nivison, Orge, Cibele, Costa, Federico, Reis, Mitermayer G., Thomas, Neena M., Eisenreich, Thomas, Weinberger, Daniel M., de Almeida, Antonio R.P., West, Anthony P., Rice, Charles M., Bjorkman, Pamela J., Reyes-Teran, Gustavo, Ko, Albert I., MacDonald, Margaret R., Nussenzweig, Michel C.

“…Antibodies to Zika virus (ZIKV) can be protective. To examine the antibody response in individuals who develop high titers of anti-ZIKV antibodies, we screened…”
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Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice by Cohen, Alexander A, Gnanapragasam, Priyanthi N P, Lee, Yu E, Hoffman, Pauline R, Ou, Susan, Kakutani, Leesa M, Keeffe, Jennifer R, Wu, Hung-Jen, Howarth, Mark, West, Anthony P, Barnes, Christopher O, Nussenzweig, Michel C, Bjorkman, Pamela J

“…Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-related emergent zoonotic coronaviruses is urgently needed. We made…”
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Antibody 10-1074 suppresses viremia in HIV-1-infected individuals by Caskey, Marina, Schoofs, Till, Gruell, Henning, Settler, Allison, Karagounis, Theodora, Kreider, Edward F, Murrell, Ben, Pfeifer, Nico, Nogueira, Lilian, Oliveira, Thiago Y, Learn, Gerald H, Cohen, Yehuda Z, Lehmann, Clara, Gillor, Daniel, Shimeliovich, Irina, Unson-O'Brien, Cecilia, Weiland, Daniela, Robles, Alexander, Kümmerle, Tim, Wyen, Christoph, Levin, Rebeka, Witmer-Pack, Maggi, Eren, Kemal, Ignacio, Caroline, Kiss, Szilard, West, Anthony P, Mouquet, Hugo, Zingman, Barry S, Gulick, Roy M, Keler, Tibor, Bjorkman, Pamela J, Seaman, Michael S, Hahn, Beatrice H, Fätkenheuer, Gerd, Schlesinger, Sarah J, Nussenzweig, Michel C, Klein, Florian

“…Florian Klein and colleagues report that treating viremic HIV-1-infected individuals with the broadly neutralizing antibody 10-1074 reduced virus levels in…”
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Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site by Gristick, Harry B, von Boehmer, Lotta, West Jr, Anthony P, Schamber, Michael, Gazumyan, Anna, Golijanin, Jovana, Seaman, Michael S, Fätkenheuer, Gerd, Klein, Florian, Nussenzweig, Michel C, Bjorkman, Pamela J

“…Crystal structures of HIV Env trimer with native glycosylation in complex with neutralizing antibodies reveal a glycan shield of high-mannose and complex-type…”
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Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors by Zhou, Tongqing, Lynch, Rebecca M., Chen, Lei, Acharya, Priyamvada, Wu, Xueling, Doria-Rose, Nicole A., Joyce, M. Gordon, Lingwood, Daniel, Soto, Cinque, Bailer, Robert T., Ernandes, Michael J., Kong, Rui, Longo, Nancy S., Louder, Mark K., McKee, Krisha, O’Dell, Sijy, Schmidt, Stephen D., Tran, Lillian, Yang, Zhongjia, Druz, Aliaksandr, Luongo, Timothy S., Moquin, Stephanie, Srivatsan, Sanjay, Yang, Yongping, Zhang, Baoshan, Zheng, Anqi, Pancera, Marie, Kirys, Tatsiana, Georgiev, Ivelin S., Gindin, Tatyana, Peng, Hung-Pin, Yang, An-Suei, Mullikin, James C., Gray, Matthew D., Stamatatos, Leonidas, Burton, Dennis R., Koff, Wayne C., Cohen, Myron S., Haynes, Barton F., Casazza, Joseph P., Connors, Mark, Corti, Davide, Lanzavecchia, Antonio, Sattentau, Quentin J., Weiss, Robin A., West, Anthony P., Bjorkman, Pamela J., Scheid, Johannes F., Nussenzweig, Michel C., Shapiro, Lawrence, Mascola, John R., Kwong, Peter D.

“…The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of…”
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Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques by Escolano, Amelia, Gristick, Harry B., Abernathy, Morgan E., Merkenschlager, Julia, Gautam, Rajeev, Oliveira, Thiago Y., Pai, Joy, West, Anthony P., Barnes, Christopher O., Cohen, Alexander A., Wang, Haoqing, Golijanin, Jovana, Yost, Daniel, Keeffe, Jennifer R., Wang, Zijun, Zhao, Peng, Yao, Kai-Hui, Bauer, Jens, Nogueira, Lilian, Gao, Han, Voll, Alisa V., Montefiori, David C., Seaman, Michael S., Gazumyan, Anna, Silva, Murillo, McGuire, Andrew T., Stamatatos, Leonidas, Irvine, Darrell J., Wells, Lance, Martin, Malcolm A., Bjorkman, Pamela J., Nussenzweig, Michel C.

“…Broadly neutralizing monoclonal antibodies protect against infection with HIV-1 in animal models, suggesting that a vaccine that elicits these antibodies would…”
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Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike by Scharf, Louise, Scheid, Johannes F., Lee, Jeong Hyun, West, Anthony P., Chen, Courtney, Gao, Han, Gnanapragasam, Priyanthi N.P., Mares, René, Seaman, Michael S., Ward, Andrew B., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Broadly neutralizing antibodies (bNAbs) to HIV-1 envelope glycoprotein (Env) can prevent infection in animal models. Characterized bNAb targets, although key…”
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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV by Scheid, Johannes F., Barnes, Christopher O., Eraslan, Basak, Hudak, Andrew, Keeffe, Jennifer R., Cosimi, Lisa A., Brown, Eric M., Muecksch, Frauke, Weisblum, Yiska, Zhang, Shuting, Delorey, Toni, Woolley, Ann E., Ghantous, Fadi, Park, Sung-Moo, Phillips, Devan, Tusi, Betsabeh, Huey-Tubman, Kathryn E., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Rzasa, Kara, Hatziioanno, Theodora, Durney, Michael A., Gu, Xiebin, Tada, Takuya, Landau, Nathaniel R., West, Anthony P., Rozenblatt-Rosen, Orit, Seaman, Michael S., Baden, Lindsey R., Graham, Daniel B., Deguine, Jacques, Bieniasz, Paul D., Regev, Aviv, Hung, Deborah, Bjorkman, Pamela J., Xavier, Ramnik J.

“…Monoclonal antibodies (mAbs) are a focus in vaccine and therapeutic design to counteract severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its…”
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CATNAP: a tool to compile, analyze and tally neutralizing antibody panels by Yoon, Hyejin, Macke, Jennifer, West, Jr, Anthony P, Foley, Brian, Bjorkman, Pamela J, Korber, Bette, Yusim, Karina

“…CATNAP (Compile, Analyze and Tally NAb Panels) is a new web server at Los Alamos HIV Database, created to respond to the newest advances in HIV neutralizing…”
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Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses by Shrock, Ellen L, Timms, Richard T, Kula, Tomasz, Mena, Elijah L, West, Jr, Anthony P, Guo, Rui, Lee, I-Hsiu, Cohen, Alexander A, McKay, Lindsay G A, Bi, Caihong, Leng, Yumei, Fujimura, Eric, Horns, Felix, Li, Mamie, Wesemann, Duane R, Griffiths, Anthony, Gewurz, Benjamin E, Bjorkman, Pamela J, Elledge, Stephen J

“…Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The…”
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Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design by Diskin, Ron, Scheid, Johannes F., Marcovecchio, Paola M., West, Anthony P., Klein, Florian, Gao, Han, Gnanapragasam, Priyanthi N. P., Abadir, Alexander, Seaman, Michael S., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can show exceptional potency and breadth. We determined structures of…”
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Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York by West, Anthony P., Wertheim, Joel O., Wang, Jade C., Vasylyeva, Tetyana I., Havens, Jennifer L., Chowdhury, Moinuddin A., Gonzalez, Edimarlyn, Fang, Courtney E., Di Lonardo, Steve S., Hughes, Scott, Rakeman, Jennifer L., Lee, Henry H., Barnes, Christopher O., Gnanapragasam, Priyanthi N. P., Yang, Zhi, Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Keeffe, Jennifer R., Bjorkman, Pamela J.

“…Wide-scale SARS-CoV-2 genome sequencing is critical to tracking viral evolution during the ongoing pandemic. We develop the software tool, Variant Database…”
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A conditional knockout resource for the genome-wide study of mouse gene function by Skarnes, William C., Rosen, Barry, West, Anthony P., Koutsourakis, Manousos, Bushell, Wendy, Iyer, Vivek, Mujica, Alejandro O., Thomas, Mark, Harrow, Jennifer, Cox, Tony, Jackson, David, Severin, Jessica, Biggs, Patrick, Fu, Jun, Nefedov, Michael, de Jong, Pieter J., Stewart, A. Francis, Bradley, Allan

“…Gene targeting in embryonic stem cells has become the principal technology for manipulation of the mouse genome, offering unrivalled accuracy in allele design…”
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Convergent antibody responses to SARS-CoV-2 in convalescent individuals by Robbiani, Davide F., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. C., Wang, Zijun, Cho, Alice, Agudelo, Marianna, Barnes, Christopher O., Gazumyan, Anna, Finkin, Shlomo, Hägglöf, Thomas, Oliveira, Thiago Y., Viant, Charlotte, Hurley, Arlene, Hoffmann, Hans-Heinrich, Millard, Katrina G., Kost, Rhonda G., Cipolla, Melissa, Gordon, Kristie, Bianchini, Filippo, Chen, Spencer T., Ramos, Victor, Patel, Roshni, Dizon, Juan, Shimeliovich, Irina, Mendoza, Pilar, Hartweger, Harald, Nogueira, Lilian, Pack, Maggi, Horowitz, Jill, Schmidt, Fabian, Weisblum, Yiska, Michailidis, Eleftherios, Ashbrook, Alison W., Waltari, Eric, Pak, John E., Huey-Tubman, Kathryn E., Koranda, Nicholas, Hoffman, Pauline R., West, Anthony P., Rice, Charles M., Hatziioannou, Theodora, Bjorkman, Pamela J., Bieniasz, Paul D., Caskey, Marina, Nussenzweig, Michel C.

“…During the coronavirus disease-2019 (COVID-19) pandemic, severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has led to the infection of…”
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Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope by Schoofs, Till, Barnes, Christopher O., Suh-Toma, Nina, Golijanin, Jovana, Schommers, Philipp, Gruell, Henning, West, Anthony P., Bach, Franziska, Lee, Yu Erica, Nogueira, Lilian, Georgiev, Ivelin S., Bailer, Robert T., Czartoski, Julie, Mascola, John R., Seaman, Michael S., McElrath, M. Juliana, Doria-Rose, Nicole A., Klein, Florian, Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Broadly neutralizing antibodies (bNAbs) against HIV-1 envelope (Env) inform vaccine design and are potential therapeutic agents. We identified SF12 and related…”
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