Search Results - "West, Anne E"

Mechanisms of specificity in neuronal activity-regulated gene transcription by Lyons, Michelle R, West, Anne E

“…The brain is a highly adaptable organ that is capable of converting sensory information into changes in neuronal function. This plasticity allows behavior to…”
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Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function by Cohen, Sonia, Gabel, Harrison W., Hemberg, Martin, Hutchinson, Ashley N., Sadacca, L. Amanda, Ebert, Daniel H., Harmin, David A., Greenberg, Rachel S., Verdine, Vanessa K., Zhou, Zhaolan, Wetsel, William C., West, Anne E., Greenberg, Michael E.

“…Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by…”
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Chromatin Regulation of Neuronal Maturation and Plasticity by Gallegos, David A., Chan, Urann, Chen, Liang-Fu, West, Anne E.

“…Neurons are dynamic cells that respond and adapt to stimuli throughout their long postmitotic lives. The structural and functional plasticity of neurons…”
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Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum by Frank, Christopher L, Liu, Fang, Wijayatunge, Ranjula, Song, Lingyun, Biegler, Matthew T, Yang, Marty G, Vockley, Christopher M, Safi, Alexias, Gersbach, Charles A, Crawford, Gregory E, West, Anne E

“…The authors use developmental changes in chromatin accessibility to identify thousands of enhancer elements that are active at different postnatal…”
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Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes by Chen, Liang-Fu, Lin, Yen Ting, Gallegos, David A., Hazlett, Mariah F., Gómez-Schiavon, Mariana, Yang, Marty G., Kalmeta, Breanna, Zhou, Allen S., Holtzman, Liad, Gersbach, Charles A., Grandl, Jörg, Buchler, Nicolas E., West, Anne E.

“…Neuronal activity-inducible gene transcription correlates with rapid and transient increases in histone acetylation at promoters and enhancers of…”
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BayFish: Bayesian inference of transcription dynamics from population snapshots of single-molecule RNA FISH in single cells by Gómez-Schiavon, Mariana, Chen, Liang-Fu, West, Anne E, Buchler, Nicolas E

“…Single-molecule RNA fluorescence in situ hybridization (smFISH) provides unparalleled resolution in the measurement of the abundance and localization of…”
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Genome binding properties of Zic transcription factors underlie their changing functions during neuronal maturation by Minto, Melyssa S, Sotelo-Fonseca, Jesús Emiliano, Ramesh, Vijyendra, West, Anne E

“…The Zic family of transcription factors (TFs) promote both proliferation and maturation of cerebellar granule neurons (CGNs), raising the question of how a…”
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Bidirectional regulation of postmitotic H3K27me3 distributions underlie cerebellar granule neuron maturation dynamics by Ramesh, Vijyendra, Liu, Fang, Minto, Melyssa S, Chan, Urann, West, Anne E

“…The functional maturation of neurons is a prolonged process that extends past the mitotic exit and is mediated by the chromatin-dependent orchestration of gene…”
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Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development by Chen, Liang-Fu, Zhou, Allen S, West, Anne E

“…The wiring of synaptic connections in the developing mammalian brain is shaped by both intrinsic and extrinsic signals. One point where these regulatory…”
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A striatal interneuron circuit for continuous target pursuit by Kim, Namsoo, Li, Haofang E., Hughes, Ryan N., Watson, Glenn D. R., Gallegos, David, West, Anne E., Kim, Il Hwan, Yin, Henry H.

“…Most adaptive behaviors require precise tracking of targets in space. In pursuit behavior with a moving target, mice use distance to target to guide their own…”
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Core and region-enriched networks of behaviorally regulated genes and the singing genome by Whitney, Osceola, Pfenning, Andreas R., Howard, Jason T., Blatti, Charles A., Liu, Fang, Ward, James M., Wang, Rui, Audet, Jean-Nicolas, Kellis, Manolis, Mukherjee, Sayan, Sinha, Saurabh, Hartemink, Alexander J., West, Anne E., Jarvis, Erich D.

“…Songbirds represent an important model organism for elucidating molecular mechanisms that link genes with complex behaviors, in part because they have discrete…”
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Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2 by Chen, Wen G., Chang, Qiang, Lin, Yingxi, Meissner, Alexander, West, Anne E., Griffith, Eric C., Jaenisch, Rudolf, Greenberg, Michael E.

“…Mutations in MeCP2, which encodes a protein that has been proposed to function as a global transcriptional repressor, are the cause of Rett syndrome (RTT), an…”
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Regulated Shuttling of the Histone Deacetylase HDAC5 to the Nucleus May Put a Brake on Cocaine Addiction by West, Anne E.

“…The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine. In this issue of Neuron, Taniguchi et al. (2012) describe a…”
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Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action by Hutchinson, Ashley N, Deng, Jay V, Cohen, Sonia, West, Anne E

“…Although tricyclic antidepressants rapidly activate monoaminergic neurotransmission, these drugs must be administered chronically to alleviate symptoms of…”
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Genomic Views of Transcriptional Enhancers: Essential Determinants of Cellular Identity and Activity-Dependent Responses in the CNS by Gray, Jesse M, Kim, Tae-Kyung, West, Anne E, Nord, Alex S, Markenscoff-Papadimitriou, Eirene, Lomvardas, Stavros

“…Sprinkled throughout the genome are a million regulatory sequences called transcriptional enhancers that activate gene promoters in the right cells, at the…”
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Regulation of transcription factors by neuronal activity by Greenberg, Michael E, West, Anne E, Griffith, Eric C

“…Synaptic activity regulates the expression of a set of neuronal gene products that are important for neuronal survival and differentiation, synaptogenesis and,…”
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The neuronal epigenome is special by West, Anne E.

“…Anne West recounts the study that showed postnatal accumulation of non-CpG DNA methylation in neurons coinciding with postnatal synapse maturation, suggesting…”
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Imaging the binding of MECP2 to DNA by West, Anne E

“…Mutations in the methyl-DNA binding domain of MECP2 cause Rett syndrome; however, distinct mutations are associated with different severity of the disease…”
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BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin by Van Kanegan, Michael J, He, Dong Ning, Dunn, Denise E, Yang, Peiying, Newman, Robert A, West, Anne E, Lo, Donald C

“…We have previously shown that the botanical drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, provides neuroprotection in both in vitro…”
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Calcium Regulation of Neuronal Gene Expression by West, Anne E., Chen, Wen G., Dalva, Matthew B., Dolmetsch, Ricardo E., Kornhauser, Jon M., Shaywitz, Adam J., Takasu, Mari A., Tao, Xu, Greenberg, Michael E.

“…Plasticity is a remarkable feature of the brain, allowing neuronal structure and function to accommodate to patterns of electrical activity. One component of…”
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