Search Results - "West, A K"

The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models by Normant, E, Paez, G, West, K A, Lim, A R, Slocum, K L, Tunkey, C, McDougall, J, Wylie, A A, Robison, K, Caliri, K, Palombella, V J, Fritz, C C

“…Heat shock protein 90 (Hsp90) is an emerging target for cancer therapy due to its important role in maintaining the activity and stability of key oncogenic…”
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New insight into the molecular pathways of metallothionein-mediated neuroprotection and regeneration by Chung, R.S, Hidalgo, J, West, A.K

“…There is a large body of evidence demonstrating that metallothioneins (MTs) expressed in astrocytes following CNS injury, exhibit both neuroprotective and…”
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Olfactory ensheathing cells are attracted to, and can endocytose, bacteria by Leung, J. Y. K, Chapman, J. A, Harris, J. A, Hale, D, Chung, R. S, West, A. K, Chuah, M. I

“…Olfactory ensheathing cells (OECs) have been shown previously to express Toll-like receptors and to respond to bacteria by translocating nuclear factor-κB from…”
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A role for extracellular metallothioneins in CNS injury and repair by Chung, R.S, West, A.K

“…For many years, research focus on metallothioneins, small zinc binding proteins found predominantly within astrocytes in the brain, has centred on their…”
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Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors by Chung, R S, Woodhouse, A, Fung, S, Dickson, T C, West, A K, Vickers, J C, Chuah, M I

“…Olfactory ensheathing cells (OECs) represent an exciting possibility for promoting axonal regeneration within the injured spinal cord. A number of studies have…”
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Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways by Leung, Y.K.J., Pankhurst, M., Dunlop, S.A., Ray, S., Dittmann, J., Eaton, E.D., Palumaa, P., Sillard, R., Chuah, M.I., West, A.K., Chung, R.S.

“…Following central nervous system injury, astrocytes rapidly respond by undergoing a stereotypical pattern of molecular and morphological alterations termed…”
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Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection by Quilty, M.C., King, A.E., Gai, W-P., Pountney, D.L., West, A.K., Vickers, J.C., Dickson, T.C.

“…Chronic oxidative stress has been linked to the neurodegenerative changes characteristic of Parkinson’s disease, particularly alpha-synuclein accumulation and…”
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Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord by Chuah, M.I., Choi-Lundberg, D., Weston, S., Vincent, A.J., Chung, R.S., Vickers, J.C., West, A.K.

“…In recent years, injection of olfactory ensheathing cells (ECs) into the spinal cord has been used as an experimental strategy to promote regeneration of…”
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Effect of olfactory ensheathing cells on reactive astrocytes in vitro by O'Toole, D. A, West, A. K, Chuah, M. I

“…Olfactory ensheathing cells have been used in several studies to promote repair in the injured spinal cord. However, cellular interaction between olfactory…”
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Vox Sanguinis International Forum on provision of granulocytes for transfusion and their clinical use: summary by Morton, S., Stanworth, S., Lozano, M., Harrison, S.J., Hong, F.S., Dennington, P., McQuilten, Z., Worel, N., Compernolle, V., Kutner, J.M., Yokoyama, A.P.H., Nahirniak, S., Germain, M., Hume, H., Robitaille, N., Wilson, A., Tinmouth, A., Massey, E., Boulat, C., Woimant, G., Tiberghien, P., Schulze, T.J., Bux, J., Pierelli, L., Ballester, C., Netelenbos, T., West, K.A., Conry‐Cantilena, C., Eder, A., Haley, N.R., Yazer, M., Triulzi, D.

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Paxillin–ARF GAP signaling and the cytoskeleton by Turner, Christopher E, West, Kip A, Brown, Michael C

“…Several new families of ARF GTPase activating proteins (ARF GAPs) have been described recently that associate with paxillin and other cytoskeletal and…”
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The LD4 Motif of Paxillin Regulates Cell Spreading and Motility through an Interaction with Paxillin Kinase Linker (PKL) by West, Kip A., Zhang, Huaye, Brown, Michael C., Nikolopoulos, Sotiris N., Riedy, M. C., Horwitz, Alan F., Turner, Christopher E.

“…The small GTPases of the Rho family are intimately involved in integrin-mediated changes in the actin cytoskeleton that accompany cell spreading and motility…”
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Adequate Early Cyclosporin Exposure is Critical to Prevent Renal Allograft Rejection: Patients Monitored by Absorption Profiling by Clase, C. M., Mahalati, K., Kiberd, B. A., Lawen, J. G., West, K. A., Fraser, A. D., Belitsky, P.

“…This study used receiver operating characteristic analysis to investigate the properties of area under the concentration‐time curve during the first 4 h after…”
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Fascin Is Involved in the Antigen Presentation Activity of Mature Dendritic Cells by Al-Alwan, Monther M, Rowden, Geoffrey, Lee, Timothy D. G, West, Kenneth A

“…Maturation of dendritic cells (DC) is critical to their development into potent APCs. Upon maturation, DC up-regulate the expression of MHC class II as well as…”
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Metallothionein expression by NG2 glial cells following CNS injury by Chung, R. S, Fung, S. J, Leung, Y. K, Walker, A. K, McCormack, G. H, Chuah, M. I, Vickers, J. C, West, A. K

“…Metallothionein (MT) expression is rapidly up-regulated following CNS injury, and there is a strong correlation between the presence or absence of MTand…”
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Metallothionein-III Inhibits Initial Neurite Formation in Developing Neurons as Well as Postinjury, Regenerative Neurite Sprouting by Chung, R.S., Vickers, J.C., Chuah, M.I., Eckhardt, B.L., West, A.K.

“…Human metallothionein-III (MT-III) is an inhibitory factor deficient in the Alzheimer's disease (AD) brain. MT-III has been identified as an inhibitor of…”
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Adequacy of lymph node harvesting in colorectal cancer management: improving standards, ensuring quality by Graham, R P D, Plummer, J M, West, K A, Williams, N P

“…The aim of this study was to determine the adequacy of nodal sampling in resection specimens for colorectal carcinoma in a Jamaican population. The pathology…”
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Partitioning and distribution of RAPD variation in a forest tree species, Eucalyptus globulus (Myrtaceae) by NESBITT, K. A, POTTS, B. M, VAILLANCOURT, R. E, WEST, A. K, REID, J. B

“…Eucalyptus globulus is an important species for pulpwood production in many countries. The pattern and partitioning of variation is important baseline…”
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Olfactory ensheathing cell phenotype following implantation in the lesioned spinal cord by Woodhall, E, West, A K, Vickers, J C, Chuah, M I

“…Although olfactory ensheathing cells (OECs) are used to promote repair in the injured spinal cord, little is known of their phenotype in this environment. In…”
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Importance of peak PRA in predicting the kidney transplant survival in highly sensitized patients by Singh, D, Kiberd, B.A, West, K.A, Kamal, K, Balbontin, F, Belitsky, P, Lawen, J

“…Do patients with high historic peak panel-reactive antibodies (PRA) remain high risk if their PRA levels fall before transplantation? We examined…”
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