Search Results - "Wessendarp, Matthew"

Targeting cholesterol homeostasis in lung diseases by Sallese, Anthony, Suzuki, Takuji, McCarthy, Cormac, Bridges, James, Filuta, Alyssa, Arumugam, Paritha, Shima, Kenjiro, Ma, Yan, Wessendarp, Matthew, Black, Diane, Chalk, Claudia, Carey, Brenna, Trapnell, Bruce C.

“…Macrophages are critical to organ structure and function in health and disease. To determine mechanisms by which granulocyte/macrophage-colony stimulating…”
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A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption by Shima, Kenjiro, Arumugam, Paritha, Sallese, Anthony, Horio, Yuko, Ma, Yan, Trapnell, Cole, Wessendarp, Matthew, Chalk, Claudia, McCarthy, Cormac, Carey, Brenna C, Trapnell, Bruce C, Suzuki, Takuji

“…Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder caused by recessive mutations in GM-CSF receptor subunit α/β genes ( / , respectively)…”
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Long-Term Safety and Efficacy of Gene-Pulmonary Macrophage Transplantation Therapy of PAP in Csf2ra−/− Mice by Arumugam, Paritha, Suzuki, Takuji, Shima, Kenjiro, McCarthy, Cormac, Sallese, Anthony, Wessendarp, Matthew, Ma, Yan, Meyer, Johann, Black, Diane, Chalk, Claudia, Carey, Brenna, Lachmann, Nico, Moritz, Thomas, Trapnell, Bruce C.

“…Hereditary pulmonary alveolar proteinosis (PAP) is a genetic lung disease characterized by surfactant accumulation and respiratory failure arising from…”
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A toxicology study of Csf2ra complementation and pulmonary macrophage transplantation therapy of hereditary PAP in mice by Arumugam, Paritha, Carey, Brenna C., Wikenheiser-Brokamp, Kathryn A., Krischer, Jeffrey, Wessendarp, Matthew, Shima, Kenjiro, Chalk, Claudia, Stock, Jennifer, Ma, Yan, Black, Diane, Imbrogno, Michelle, Collins, Margaret, Kalenda Yombo, Dan Justin, Sakthivel, Haripriya, Suzuki, Takuji, Lutzko, Carolyn, Cancelas, Jose A., Adams, Michelle, Hoskins, Elizabeth, Lowe-Daniels, Dawn, Reeves, Lilith, Kaiser, Anne, Trapnell, Bruce C.

“…Pulmonary macrophage transplantation (PMT) is a gene and cell transplantation approach in development as therapy for hereditary pulmonary alveolar proteinosis…”
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CD40 Restrains In Vivo Growth of Toxoplasma gondii Independently of Gamma Interferon by Subauste, Carlos S, Wessendarp, Matthew

“…CD40-CD154 interaction is pivotal for resistance against numerous pathogens. However, it is not known if this pathway can also enhance in vivo resistance in…”
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CD40 Signaling in Macrophages Induces Activity against an Intracellular Pathogen Independently of Gamma Interferon and Reactive Nitrogen Intermediates by Andrade, Rosa M, Portillo, Jose-Andres C, Wessendarp, Matthew, Subauste, Carlos S

“…Gamma interferon (IFN-[gamma]) is the major inducer of classical activation of macrophages. Classically activated mouse macrophages acquire antimicrobial…”
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CD40-TRAF6 and Autophagy-Dependant Anti-Microbial Activity in Macrophages by Subauste, Carlos S., Andrade, Rosa M., Wessendarp, Matthew

“…A fundamental question in host-pathogen interaction is to determine if the immune system activates fusion with the lysosomes to eradicate pathogens. We…”
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Role of CD40 Ligand Signaling in Defective Type 1 Cytokine Response in Human Immunodeficiency Virus Infection by Subauste, Carlos S., Wessendarp, Matthew, Smulian, A. George, Frame, Peter T.

“…The pathogenesis of defective interleukin (IL)–12 and interferon (IFN)–γ production in human immunodeficiency virus (HIV)–infected patients remains to be…”
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Role of GM-CSF in regulating metabolism and mitochondrial functions critical to macrophage proliferation by Wessendarp, Matthew, Watanabe-Chailland, Miki, Liu, Serena, Stankiewicz, Traci, Ma, Yan, Kasam, Rajesh K, Shima, Kenjiro, Chalk, Claudia, Carey, Brenna, Rosendale, Lindsey-Romick, Dominique Filippi, Marie, Arumugam, Paritha

“…•GM-CSF regulates mitochondrial turnover, metabolism and functions in macrophages.•Cellular ATP production is regulated by GM-CSF.•Mitochondrial fatty acid…”
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CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes by Andrade, Rosa M, Wessendarp, Matthew, Gubbels, Marc-Jan, Striepen, Boris, Subauste, Carlos S

“…Many intracellular pathogens, including Toxoplasma gondii, survive within macrophages by residing in vacuoles that avoid fusion with lysosomes. It is important…”
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CD40-TRAF6 and autophagy-dependent anti-microbial activity in macrophages by Subauste, Carlos S, Andrade, Rosa M, Wessendarp, Matthew

“…A fundamental question in host-pathogen interaction is to determine if the immune system activates fusion with the lysosomes to eradicate pathogens. We…”
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Role of CD40-Dependent Down-Regulation of CD154 in Impaired Induction of CD154 in CD4+ T Cells from HIV-1-Infected Patients by Subauste, Carlos S, Subauste, Angela, Wessendarp, Matthew

“…CD40-CD154 interaction is pivotal for cell-mediated immunity. There are contradictory reports on whether HIV-1 infection impairs CD154 induction. The…”
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Role of CD40-Dependent Down-Regulation of CD154 in Impaired Induction of CD154 in CD4 super(+) T Cells from HIV-1-Infected Patients by Subauste, Carlos S, Subauste, Angela, Wessendarp, Matthew

“…CD40-CD154 interaction is pivotal for cell-mediated immunity. There are contradictory reports on whether HIV-1 infection impairs CD154 induction. The…”
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Human dendritic cells discriminate between viable and killed Toxoplasma gondii tachyzoites: dendritic cell activation after infection with viable parasites results in CD28 and CD40 ligand signaling that controls IL-12-dependent and -independent T cell production of IFN-gamma by Subauste, C S, Wessendarp, M

“…We studied how the interaction between human dendritic cells (DC) and Toxoplasma gondii influences the generation of cell-mediated immunity against the…”
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TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha by Andrade, Rosa M, Wessendarp, Matthew, Portillo, Jose-Andres C, Yang, Jun-Qi, Gomez, Francisco J, Durbin, Joan E, Bishop, Gail A, Subauste, Carlos S

“…IFN-gamma is considered an essential stimulus that allows macrophages to acquire activity against intracellular pathogens in response to a second signal such…”
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CD40-CD40 Ligand Interaction Is Central to Cell-Mediated Immunity Against Toxoplasma gondii: Patients with Hyper IgM Syndrome Have a Defective Type 1 Immune Response That Can Be Restored by Soluble CD40 Ligand Trimer by Subauste, Carlos S, Wessendarp, Matthew, Sorensen, Ricardo U, Leiva, Lily E

“…Cell-mediated immunity that results in IL-12/IFN-gamma production is essential to control infections by intracellular organisms. Studies in animal models…”
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CD154 activates macrophage antimicrobial activity in the absence of IFN-gamma through a TNF-alpha-dependent mechanism by Andrade, Rosa M, Wessendarp, Matthew, Subauste, Carlos S

“…Protection against certain intracellular pathogens can take place in the absence of IFN-gamma through mechanisms dependent on TNF-alpha. In this regard,…”
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Pathogen-Specific Induction of CD154 Is Impaired in CD4+ T Cells from Human Immunodeficiency Virus–Infected Patients by Subauste, Carlos S., Wessendarp, Matthew, Portilllo, Jose-Andres C., Andrade, Rosa M., Hinds, Linda M., Gomez, Francisco J., Smulian, A. George, Grubbs, Peter A., Haglund, Lisa A.

“…The pathogenesis of immunodeficiency associated with human immunodeficiency virus (HIV) infection remains incompletely understood. CD154, a molecule that is…”
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Human Dendritic Cells Discriminate Between Viable and Killed Toxoplasma gondii Tachyzoites: Dendritic Cell Activation After Infection with Viable Parasites Results in CD28 and CD40 Ligand Signaling That Controls IL-12-Dependent and -Independent T Cell Production of IFN-{gamma} by Subauste, Carlos S, Wessendarp, Matthew

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CD154 Activates Macrophage Antimicrobial Activity in the Absence of IFN-{gamma} through a TNF-{alpha}-Dependent Mechanism by Andrade, Rosa M, Wessendarp, Matthew, Subauste, Carlos S

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