Search Results - "Wessels, H M"

Discontinuation of first-line disease-modifying therapy in relapse onset multiple sclerosis by Coerver, E.M.E., Bourass, A., Wessels, M.H.J., van Kempen, Z.L.E., Jasperse, M.M.S., Tonino, B.A.R., Barkhof, F., Mostert, J., Uitdehaag, B.M.J., Killestein, J., Strijbis, E.M.M.

“…•The most frequent reason for discontinuation of therapy was side effects.•Sixty percent of the participants showed disease activity after…”
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Natalizumab discontinuation in a Dutch real-world cohort by Coerver, E.M.E., Wessels, M.H.J., van Lierop, Z.Y.G., van Kempen, Z.L.E., Killestein, J., Strijbis, E.M.M.

“…To determine characteristics of multiple sclerosis patients that discontinued natalizumab treatment in a real-world cohort. Data was collected from an ongoing…”
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In vivo and in vitro pharmacokinetic differences between four structurally closely related anthracyclines in hematopoietic cell subtypes in humans by Speth, P A, Linssen, P C, Termond, E F, Boezeman, J B, Wessels, H M, Haanen, C

“…Minor differences in chemical structure of adriamycin (ADM), 4'-epiadriamycin (E-ADM), daunomycin (DNM), and 4-demethoxydaunomycin (D-DNM) lead to large…”
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Antisense BCR-ABL oligonucleotides induce apoptosis in the Philadelphia chromosome-positive cell line BV173 by Smetsers, T F, Skorski, T, van de Locht, L T, Wessels, H M, Pennings, A H, de Witte, T, Calabretta, B, Mensink, E J

“…BCR-ABL antisense oligonucleotides can specifically reduce colony formation of early hematopoietic progenitor cells from chronic myeloid leukemia (CML)…”
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Influence of personalized extended interval dosing on the natalizumab wearing-off effect - a sub-study of the NEXT-MS trial by Toorop, A.A., Wessels, M.H.J., Gelissen, L.M.Y., Hoitsma, E., Zeinstra, E.M.P.E., van Rooij, L.C., van Munster, C.E.P., Vennegoor, A., Mostert, J.P., Wokke, B.H.A., Kalkers, N.F., Hoogervorst, E.L.J., van Eijk, J.J.J., Roosendaal, C.M., Kragt, J.J., Eurelings, M., van Genugten, J., Nielsen, J., Sinnige, L.G.F., Kloosterziel, M.E., Arnoldus, E.P.J., van Dijk, G.W., Bouvy, W.H., Strijbis, E.M.M., van Oosten, B.W., de Jong, B.A., Lissenberg-Witte, B.I., Rispens, T., Uitdehaag, B.M.J., Killestein, J., van Kempen, Z.L.E.

“…Wearing-off symptoms during natalizumab treatment in multiple sclerosis are characterized by an increase of MS-related symptoms prior to natalizumab…”
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Phosphorothioate BCR-ABL antisense oligonucleotides induce cell death, but fail to reduce cellular bcr-abl protein levels by Smetsers, T F, van de Locht, L T, Pennings, A H, Wessels, H M, de Witte, T M, Mensink, E J

“…The bcr-abl oncogene is a fusion gene resulting from a reciprocal translocation which forms the hallmark of chronic myeloid leukemia (CML). Antisense…”
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Cellular and plasma adriamycin concentrations in long-term infusion therapy of leukemia patients by SPETH, P. A. J, LINSSEN, P. C. M, BOEZEMAN, J. B. M, WESSELS, H. M. C, HAANEN, C

“…To determine whether long-term adriamycin (ADM) infusions resulted in cellular ADM concentrations at least comparable to those observed after bolus injections,…”
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Cell Cycle Kinetics in Malignant Lymphoma Studied With In Vivo Iododeoxyuridine Administration, Nuclear Ki-67 Staining, and Flow Cytometry by Brons, Paul P.T., Raemaekers, John M.M., Bogman, M. José J.T., Erp, Piet E.J. van, Boezeman, Jan B.M., Pennings, Arie H.M., Wessels, Hans M.C., Haanen, Clemens

“…Cell cycle kinetics of malignant lymphoma were investigated using in vivo labeling with iododeoxyuridine (IdUrd) and subsequent flow cytometry (FCM) of…”
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Proliferation patterns in acute myeloid leukemia : leukemic clonogenic growth and in vivo cell cycle kinetics by BRONS, P. P. T, HAANEN, C, BOEZEMAN, J. B. M, MUUS, P, HOLDRINET, R. S. G, PENNINGS, A. H. M, WESSELS, H. M. C, DE WITTE, T

“…In a prospective study of 33 newly diagnosed patients with acute myeloid leukemia (AML), we analyzed the relationship of proliferation parameters with clinical…”
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Leukemic cell and plasma daunomycin concentrations after bolus injection and 72 h infusion by SPETH, P. A. J, LINSSEN, P. C. M, BOEZEMAN, J. B. M, WESSELS, H. M. C, HAANEN, C

“…The effect of the duration of daunomycin (DNM) infusion on leukemic cell drug concentrations was evaluated. Cellular and plasma DNM concentrations were…”
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Detection of point mutations in DNA using capillary electrophoresis in a polymer network by Kuypers, A W, Willems, P M, van der Schans, M J, Linssen, P C, Wessels, H M, de Bruijn, C H, Everaerts, F M, Mensink, E J

“…The use of capillary electrophoresis (CE) in a polymer network for single-strand conformation polymorphism (SSCP) is investigated. SSCP is a method to detect…”
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Simultaneous measurement of DNA content and cell‐surface immunofluorescence of human bone marrow cells using a single laser flow cytometer by Brons, Paul P. T., Pennings, Arie H. M., Haanen, Clemens, Wessels, Hans M. C., Boezeman, Jan B. M.

“…This paper describes the measurement of S phase DNA content in human bone marrow subpopulations using a single laser method for bivariate analysis of DNA…”
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Practical evaluation of mammary carcinoma by WESSELS, M H

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In vivo cellular adriamycin concentrations related to growth inhibition of normal and leukemic human bone marrow cells by Speth, P A, Raijmakers, R A, Boezeman, J B, Linssen, P C, de Witte, T J, Wessels, H M, Haanen, C

“…Inhibition of clonogenicity of normal and leukemic human hematopoietic progenitor cells was studied after in vivo and in vitro exposure of bone marrow to…”
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Incorporation of nucleic acid and protein precursors in enriched populations of proliferating normal and leukemic cells by Burghouts, J T, Plas, A M, Salden, M H, Wessels, H M

“…Nucleic acid and protein synthesis was determined in immature myeloid cells isolated from seven normal bone marrow samples and compared to blasts from nine…”
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Effect of isotype on internalization and cytotoxicity of CD19-ricin A immunotoxins by van Oosterhout, Y V, van den Herik-Oudijk, I E, Wessels, H M, de Witte, T, van de Winkel, J G, Preijers, F W

“…We analyzed the effect of isotype variation on effectiveness of B-cell CD19 immunotoxins (IT) by using class switch variants (CLB-B4-IgG1 and CLB-B4-IgG2a)…”
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Cytotoxicity of CD3-ricin A chain immunotoxins in relation to cellular uptake and degradation kinetics by van Oosterhout, Y V, Preijers, F W, Wessels, H M, de Witte, T

“…The cytotoxicity of WT32 (CD3)-ricin A immunotoxin (IT) to the acute lymphoblastic leukemia T-cell line Jurkat was compared with the rate of internalization…”
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Cytoxicity of CD3-ricin A chain immunotoxins in relation to cellular uptake and degradation kinetics by VAN OOSTERHOUT, Y. V. J. M, PREIJERS, F. W. M. B, WESSELS, H. M. C, DE WITTE, T

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Effect of isotype on internalization and cytoxicity of CD19-ricin A immunotoxins by VAN OOSTERHOUT, Y. V. J. M, VAN DEN HERIK-OUDIJK, I. E, WESSELS, H. M. C, DE WITTE, T, VAN DE WENKEL, J. G. J, PREIJERS, F. W. M. B

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Plasma and human leukemic cell pharmacokinetics of oral and intravenous 4-demethoxydaunomycin by Speth, P A, van de Loo, F A, Linssen, P C, Wessels, H M, Haanen, C

“…On 3 consecutive days, 4-demethoxydaunomycin (D-DNM) was administered orally (30 mg/m2) as bolus injection and 4- or 24-hour infusion to seven patients with…”
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