Search Results - "Wessels, Deborah J."

Reciprocal signaling and direct physical interactions between fibroblasts and breast cancer cells in a 3D environment by Wessels, Deborah J, Pradhan, Nikash, Park, Yang-Nim, Klepitsch, Megan A, Lusche, Daniel F, Daniels, Karla J, Conway, Kayla D, Voss, Edward R, Hegde, Suchaeta V, Conway, Thomas P, Soll, David R

“…Tumorigenic cells undergo cell aggregation and aggregate coalescence in a 3D Matrigel environment. Here, we expanded this 3D platform to assess the…”
Get full text

New monoclonal antibodies that recognize an unglycosylated, conserved, extracellular region of CD44 in vitro and in vivo, and can block tumorigenesis by Lusche, Daniel F, Wessels, Deborah J, Reis, Ryan J, Forrest, Cristopher C, Thumann, Alexis R, Soll, David R

“…CD44 is a transmembrane glycoprotein that binds to hyaluronic acid, plays roles in a number of cellular processes and is expressed in a variety of cell types…”
Get full text

Directed movement toward, translocation along, penetration into and exit from vascular networks by breast cancer cells in 3D by Wessels, Deborah J., Pujol, Claude, Pradhan, Nikash, Lusche, Daniel F., Gonzalez, Luis, Kelly, Sydney E., Martin, Elizabeth M., Voss, Edward R., Park, Yang-Nim, Dailey, Michael, Sugg, Sonia L., Phadke, Sneha, Bashir, Amani, Soll, David R.

“…We developed a computer-assisted platform using laser scanning confocal microscopy to 3D reconstruct in real-time interactions between metastatic breast cancer…”
Get full text

Candida albicans Double Mutants Lacking both EFG1 and WOR1 Can Still Switch to Opaque by Park, Yang-Nim, Pujol, Claude, Wessels, Deborah J., Soll, David R.

“…The switch from white to opaque in Candida albicans was discovered 33 years ago, but it is still unclear how it is regulated. A regulatory paradigm has emerged…”
Get full text

Quantitative Motion Analysis in Two and Three Dimensions by Wessels, Deborah J, Lusche, Daniel F, Kuhl, Spencer, Scherer, Amanda, Voss, Edward, Soll, David R

“…This chapter describes 2D quantitative methods for motion analysis as well as 3D motion analysis and reconstruction methods. Emphasis is placed on the analysis…”
Get more information

Integrin α-3 ß-1's central role in breast cancer, melanoma and glioblastoma cell aggregation revealed by antibodies with blocking activity by Lusche, Daniel F, Klemme, Michael R, Soll, Benjamin A, Reis, Ryan J, Forrest, Cristopher C, Nop, Tiffany S, Wessels, Deborah J, Berger, Brian, Glover, Rebecca, Soll, David R

“…Breast cancer, melanoma and glioblastoma cells undergo cell-mediated aggregation and aggregate coalescence in a transparent 3D Matrigel environment. Cells from…”
Get full text

Overexpressing TPTE2 ( TPIP ), a homolog of the human tumor suppressor gene PTEN , rescues the abnormal phenotype of the PTEN -/- mutant by Lusche, Daniel F, Buchele, Emma C, Russell, Kanoe B, Soll, Benjamin A, Vitolo, Michele I, Klemme, Michael R, Wessels, Deborah J, Soll, David R

“…One possible approach to normalize mutant cells that are metastatic and tumorigenic, is to upregulate a functionally similar homolog of the mutated gene. Here…”
Get full text

Light microscopy to image and quantify cell movement by Wessels, Deborah J, Kuhl, Spencer, Soll, David R

“…For decades, Dictyostelium discoideum has been an efficacious and attractive model system for the study of cell motility, primarily because cells become highly…”
Get more information

The internal phosphodiesterase RegA is essential for the suppression of lateral pseudopods during Dictyostelium chemotaxis by Wessels, D J, Zhang, H, Reynolds, J, Daniels, K, Heid, P, Lu, S, Kuspa, A, Shaulsky, G, Loomis, W F, Soll, D R

“…Dictyostelium strains in which the gene encoding the cytoplasmic cAMP phosphodiesterase RegA is inactivated form small aggregates. This defect was corrected by…”
Get full text

Pseudopodium dynamics and rapid cell movement in Dictyostelium Ras pathway mutants by Chubb, Jonathan R., Wilkins, Andrew, Wessels, Deborah J., Soll, David R., Insall, Robert H.

“…Loss of either of the Ras pathway members RasS or GefB causes growing Dictyostelium cells to move aberrantly rapidly. In this study, we describe the changes in…”
Get full text

Candida albicans Double Mutants Lacking both italic toggle="yes">EFG1 /italic> and italic toggle="yes">WOR1 /italic> Can Still Switch to Opaque by Yang-Nim Park, Claude Pujol, Deborah J. Wessels, David R. Soll

“…ABSTRACT Candida albicans, a pervasive opportunistic pathogen, undergoes a unique phenotypic transition from a “white” phenotype to an “opaque” phenotype. The…”
Get full text

Integrin α-3 ß-1's central role in breast cancer, melanoma and glioblastoma cell aggregation revealed by antibodies with blocking activity by Lusche, Daniel F., Klemme, Michael R., Soll, Benjamin A., Reis, Ryan J., Forrest, Cristopher C., Nop, Tiffany S., Wessels, Deborah J., Berger, Brian, Glover, Rebecca, Soll, David R.

“…Breast cancer, melanoma and glioblastoma cells undergo cell-mediated aggregation and aggregate coalescence in a transparent 3D Matrigel environment. Cells from…”
Get full text